Tim Meyer
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View article: Impact of the ‘FUNBALL’ Programme on Severe Injuries Among Young Male Football Players: A Secondary Analysis from a Cluster-Randomised Controlled Trial
Impact of the ‘FUNBALL’ Programme on Severe Injuries Among Young Male Football Players: A Secondary Analysis from a Cluster-Randomised Controlled Trial Open
Background ‘FUNBALL’ is a new multi-component exercise-based injury prevention programme designed specifically for youth football players. Its efficacy in reducing the overall number of injuries has been previously reported. The aim of thi…
View article: Figure 3 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Figure 3 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors Open
Effector T cells in metastatic tissue are significantly more regulated compared with other tissue types. Co-expressions of key B7 and TNFR superfamily coinhibitory and costimulatory molecules on T-cell subsets were quantified using PD-1 as…
View article: Figure 4 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Figure 4 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors Open
The geographical immune landscape in siNET shows predominantly peri-tumoral T cells. A and B, IHC staining of siNET. T-cell subsets stained are CD8+ T cells (red), CD4+ T cells (brown), and FoxP3+
View article: Figure 2 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Figure 2 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors Open
CD8+ in metastatic tissue is more regulated compared with other tissue types. Co-expressions of key B7 and TNFR superfamily co-inhibitory and co-stimulatory molecules on T-cell subsets were quantified by flow cytometry with matc…
View article: Table 1 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Table 1 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors Open
Clinicopathological features of siNET cohort.
View article: Figure 5 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Figure 5 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors Open
SiNET mutational load. This shows a comparison of the siNET mutational load against 33 TCGA cohorts from the Multicenter Mutation Calling in Multiple Cancers (MC3; ref. 63) project.
View article: Figure 1 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Figure 1 from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors Open
Effector/Treg ratio is significantly lower in tumor tissues and CD8+ in metastatic tissue is significantly more regulated compared with other tissue types. A, The horizontal black bars indicate the median values for each …
View article: Effects of Pre-cooling and Cooling Breaks on Thermoregulatory, Physiological and Match Running Responses During Football in Moderate and Hot Temperatures
Effects of Pre-cooling and Cooling Breaks on Thermoregulatory, Physiological and Match Running Responses During Football in Moderate and Hot Temperatures Open
Purpose This study investigated the effects of pre-cooling and cooling breaks on thermoregulatory, hydration and running responses in football (soccer) players in moderate and hot temperatures. Methods Forty male youth footballers particip…
View article: Harmonisation and implementation of sports-related concussion guidelines in European youth football: the REFORM Erasmus+ project
Harmonisation and implementation of sports-related concussion guidelines in European youth football: the REFORM Erasmus+ project Open
Introduction Sports-related concussions (SRCs) are frequently under-reported in youth sports, especially football, due to limited awareness, inconsistent reporting practices and a lack of medical personnel at the grassroots level. Concussi…
View article: What is the most appropriate age for the first cardiac screening of athletes?
What is the most appropriate age for the first cardiac screening of athletes? Open
View article: Moderate-intensity aerobic exercise training as an adjunct to trauma-focused psychotherapy in traumatized refugees and asylum seekers: study protocol of a randomized controlled trial
Moderate-intensity aerobic exercise training as an adjunct to trauma-focused psychotherapy in traumatized refugees and asylum seekers: study protocol of a randomized controlled trial Open
Background: Refugees with exposure to multiple traumatic events are at high risk for developing posttraumatic stress disorder (PTSD) and depression. Narrative exposure therapy (NET) is an effective treatment for the core symptoms of…
View article: Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues
Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues Open
Tissue engineering with human cardiac fibroblasts (CF) allows identifying novel mechanisms and anti-fibrotic drugs in the context of cardiac fibrosis. However, substantial knowledge on the influences of the used materials and tissue geomet…
View article: <i>M</i><i>ycobacterium tuberculosis</i>-specific CD4 T-cell scoring discriminates tuberculosis infection from disease
<i>M</i><i>ycobacterium tuberculosis</i>-specific CD4 T-cell scoring discriminates tuberculosis infection from disease Open
Background Rapid and reliable diagnostic work-up of tuberculosis (TB) remains a major healthcare goal. In particular, discrimination of TB infection from TB disease with currently available diagnostic tools is challenging and time consumin…
View article: Dwarfs on the Shoulders of Giants: Bayesian Analysis With Informative Priors in Elite Sports Research and Decision Making
Dwarfs on the Shoulders of Giants: Bayesian Analysis With Informative Priors in Elite Sports Research and Decision Making Open
While sample sizes in elite sports are necessarily small, so are the effects that may be relevant. This conundrum is complicated by an understandable reluctance of athletes to comply with extensive study requirements. In Bayesian analyses,…
View article: Three-Component Suzuki–Knoevenagel Synthesis of Merocyanine Libraries and Correlation Analyses of Their Oxidation Potentials and Optical Band Gaps
Three-Component Suzuki–Knoevenagel Synthesis of Merocyanine Libraries and Correlation Analyses of Their Oxidation Potentials and Optical Band Gaps Open
The Suzuki coupling Knoevenagel condensation one-pot synthesis of boronic acids/esters, (hetero)aromatic bromo aldehydes and methylene active compounds is a highly practical consecutive three-component process to provide substance librarie…
View article: Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer
Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer Open
Purpose: To evaluate the mechanisms of how therapeutic upregulation of the transcription factor, CCAAT/enhancer-binding protein alpha (C/EBPα), prevents tumor progression in patients with advanced hepatocellular carcinoma (HCC) and in diff…
View article: Mild COVID-19 despite autoantibodies against type I IFNs in autoimmune polyendocrine syndrome type 1
Mild COVID-19 despite autoantibodies against type I IFNs in autoimmune polyendocrine syndrome type 1 Open
Autoantibodies against IFN-α and IFN-ω (type I IFNs) were recently reported as causative for severe COVID-19 in the general population. Autoantibodies against IFN-α and IFN-ω are present in almost all patients with autoimmune polyendocrine…
View article: Recovery-Stress Response of Blood-Based Biomarkers
Recovery-Stress Response of Blood-Based Biomarkers Open
The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous bl…
View article: Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint Open
Determining divergent metabolic requirements of T cells, and the viruses and tumours they fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) has direct anti-carcinogenic act…
View article: Assessment of sleep quality and daytime sleepiness in German national ice hockey players preparing for the world championship
Assessment of sleep quality and daytime sleepiness in German national ice hockey players preparing for the world championship Open
Objectives Objectives were to examine subjective sleep quality and daytime sleepiness of the German ice hockey junior national team prior to the world championship to identify athletes of concern and areas of optimization with the intentio…
View article: Portable polysomnography for sleep monitoring in elite youth rowing: An athlete's gain or the sleep's thief?
Portable polysomnography for sleep monitoring in elite youth rowing: An athlete's gain or the sleep's thief? Open
Portable polysomnography (PSG) is a promising tool to assess sleep architecture and stages in athletes, yet there are hardly any research findings concerning comfort and practicability within the applied field. Thus, aim of this study was …
View article: Serum Alpha-fetoprotein Levels and Clinical Outcomes in the Phase III CELESTIAL Study of Cabozantinib versus Placebo in Patients with Advanced Hepatocellular Carcinoma
Serum Alpha-fetoprotein Levels and Clinical Outcomes in the Phase III CELESTIAL Study of Cabozantinib versus Placebo in Patients with Advanced Hepatocellular Carcinoma Open
Purpose: The phase III CELESTIAL study demonstrated improved overall survival (OS) and progression-free survival (PFS) with cabozantinib versus placebo in patients with previously treated, advanced hepatocellular carcinoma (HCC). We analyz…
View article: Generation of Engineered Human Myocardium in a Multi-well Format
Generation of Engineered Human Myocardium in a Multi-well Format Open
This protocol describes a robust method for the generation of engineered human myocardium (EHM) from pluripotent stem cells (PSCs) in a multi-well plate under defined, serum-free conditions. By parallel culture of up to 48 EHM in one plate…
View article: NET-02 trial protocol: a multicentre, randomised, parallel group, open-label, phase II, single-stage selection trial of liposomal irinotecan (nal-IRI) and 5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy in patients with progressive poorly differentiated extrapulmonary neuroendocrine carcinoma (NEC)
NET-02 trial protocol: a multicentre, randomised, parallel group, open-label, phase II, single-stage selection trial of liposomal irinotecan (nal-IRI) and 5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy in patients with progressive poorly differentiated extrapulmonary neuroendocrine carcinoma (NEC) Open
Introduction Poorly differentiated (PD), extrapulmonary (EP), neuroendocrine carcinomas (NECs) are rare but aggressive neuroendocrine neoplasms. First-line treatment for advanced disease is an etoposide and platinum-based chemotherapy comb…
View article: A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms Open
Second-generation mammalian target of rapamycin (mTOR) inhibitors such as CC-223 may have theoretical advantages over first-generation drugs by inhibiting TOR kinase in mTOR complex 1 (mTORC1) and 2 (mTORC2), potentially improving clinical…
View article: Effects of different recovery strategies following a half-marathon on fatigue markers in recreational runners
Effects of different recovery strategies following a half-marathon on fatigue markers in recreational runners Open
In recreational runners, a half-marathon results in fatigue symptoms lasting at least 24h. To restore subjective fatigue measures, the authors recommend CWI and MAS, as these recovery strategies are more effective than PAS, with ACT being …
View article: Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study
Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study Open
This randomized controlled trial shows that endurance training, IT, and RT protocols induce specific cellular pathways in circulating leucocytes. Endurance training and IT, but not RT, increased telomerase activity and TL which are importa…
View article: Relation Between Training Load and Recovery-Stress State in High-Performance Swimming
Relation Between Training Load and Recovery-Stress State in High-Performance Swimming Open
Background: The relation between training load, especially internal load, and the recovery-stress state is of central importance for avoiding negative adaptations in high-performance sports like swimming. The aim of this study was t…
View article: Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial
Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial Open
View article: C–H/O Interactions of Aromatic CH Donors within Proteins: A Crystallographic Study
C–H/O Interactions of Aromatic CH Donors within Proteins: A Crystallographic Study Open
C-H/O interactions of aromatic C-H donors within proteins have been studied by analyzing the data in the Protein Data Bank (PDB). The C-H/O interactions were studied between aromatic donors; phenylalanine, tyrosine, and tryptophan and the …