Tim Moons
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View article: Reduced interhemispheric and increased intrahemispheric connectivity in schizophrenia brain networks
Reduced interhemispheric and increased intrahemispheric connectivity in schizophrenia brain networks Open
Introduction Brain connectivity is disturbed in schizophrenia, both during resting state and during active tasks. Schizophrenia is characterised by a corpus callosum pathology and an inability to suppress overstimulation, both of which rel…
View article: Gene‐based interaction analysis shows <scp>GABA</scp> ergic genes interacting with parenting in adolescent depressive symptoms
Gene‐based interaction analysis shows <span>GABA</span> ergic genes interacting with parenting in adolescent depressive symptoms Open
Background Most gene‐environment interaction studies (G × E) have focused on single candidate genes. This approach is criticized for its expectations of large effect sizes and occurrence of spurious results. We describe an approach that ac…
View article: Autosomal SNPs that had a p-value below 10<sup>−4</sup> after logistic regression using the first 3 principal components.
Autosomal SNPs that had a p-value below 10<sup>−4</sup> after logistic regression using the first 3 principal components. Open
Autosomal SNPs that had a p-value below 10−4 after logistic regression using the first 3 principal components.
View article: Top 5 genes with at least 3 SNPs per gene from the SKAT CommonRare analysis, using the first 3 principal components as covariates.
Top 5 genes with at least 3 SNPs per gene from the SKAT CommonRare analysis, using the first 3 principal components as covariates. Open
Top 5 genes with at least 3 SNPs per gene from the SKAT CommonRare analysis, using the first 3 principal components as covariates.
View article: Replication of previously reported autosomal SNPs associated with schizophrenia in GWAS studies.[9–22].
Replication of previously reported autosomal SNPs associated with schizophrenia in GWAS studies.[9–22]. Open
p-values were obtained using logistic regression with the first 3 principal components as covariates.
View article: Genetic Evaluation of Schizophrenia Using the Illumina HumanExome Chip
Genetic Evaluation of Schizophrenia Using the Illumina HumanExome Chip Open
From the initial 242901 SNVs, 88306 had at least one minor allele and passed quality control. No variant reached genomewide-significant results (p<10(-8)). The SNP with the lowest p-value was rs1230345 in WISP3 (p = 3.05*10(-6)), followed …