Tim Oqueka
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View article: Telomere biology disorder associated lung disease- case report of a <i>TERT</i> gene variant as the cause of pleuroparenchymal fibroelastosis
Telomere biology disorder associated lung disease- case report of a <i>TERT</i> gene variant as the cause of pleuroparenchymal fibroelastosis Open
Case presentation Description of a patient with a progressive destructive lung disease resembling pleuroparenchymal fibroelastosis, liver cirrhosis and bone marrow changes. Genetic workup identified a rare heterozygous coding variant in th…
View article: Daratumumab as rescue therapy in life-threatening granulomatosis with polyangiitis
Daratumumab as rescue therapy in life-threatening granulomatosis with polyangiitis Open
Journal Article Corrected proof Daratumumab as rescue therapy in life-threatening granulomatosis with polyangiitis Get access Martin Krusche, Martin Krusche III Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, …
View article: Dupilumab therapy in chronic rhinosinusitis with polyposis nasi and concurrent therapy with infliximab – a case presentation
Dupilumab therapy in chronic rhinosinusitis with polyposis nasi and concurrent therapy with infliximab – a case presentation Open
Introduction Since 2019, immunotherapy of chronic rhinosinusitis with polyposis nasi (CRSwNP) has been established as another treatment option. Data on possible interaction potential of the currently approved antibodies (dupilumab, omalizu…
View article: Respiratory Muscle Dysfunction in COVID-19 Patients with Persistent Symptoms
Respiratory Muscle Dysfunction in COVID-19 Patients with Persistent Symptoms Open
In a cross-sectional analysis, we have identified a high prevalence of respiratory muscle dysfunction in persistently symptomatic patients after COVID-19 (‘Long COVID’). Respiratory muscle impairment in these patients was associated with e…
View article: Additional file 2 of Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study
Additional file 2 of Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study Open
Additional file 2: Table S1. Detailed information on the IV used in the MR analyses. Table S2. Intercept from Egger-regression analyses. Table S3. Results from single SNP MR based on the ratio estimate and from leave-one-out MR based on th…
View article: Granulomatosis with polyangiitis: mind the airway
Granulomatosis with polyangiitis: mind the airway Open
Key message Granulomatosis with polyangiitis (GPA) is a potentially life‐threatening disease that affects all ages. As the disease may be rapidly progressive, the undelayed recognition of its inflammatory activity is critical. This is espe…
View article: Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry
Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry Open
Objective There is a paucity of observational data on antifibrotic therapy for idiopathic pulmonary fibrosis (IPF). We aimed to assess the course of disease of IPF patients with and without antifibrotic therapy under real-life conditions. …
View article: Late Breaking Abstract - Survival and course of lung function in patients with idiopathic pulmonary fibrosis with or without antifibrotic treatment: long-term results of the INSIGHTS-IPF registry
Late Breaking Abstract - Survival and course of lung function in patients with idiopathic pulmonary fibrosis with or without antifibrotic treatment: long-term results of the INSIGHTS-IPF registry Open
While antifibrotic therapy is approved for idiopathic pulmonary fibrosis (IPF) based on clinical trials, we aimed to assess the effects of such treatment under real life conditions. We analysed data from a non-interventional, prospective c…
View article: Endoscopic lung volume reduction coil treatment in patients with very low FEV<sub>1</sub>: an observational study
Endoscopic lung volume reduction coil treatment in patients with very low FEV<sub>1</sub>: an observational study Open
Background: Endoscopic lung volume reduction coil (LVRC) treatment is a therapeutic option for selected patients with advanced emphysema. The effects and the safety of endoscopic lung volume reduction in patients with very low forced expir…
View article: Endoscopic lung volume reduction coil treatment in patients with chronic hypercapnic respiratory failure: an observational study
Endoscopic lung volume reduction coil treatment in patients with chronic hypercapnic respiratory failure: an observational study Open
Background: Endoscopic lung volume reduction coil (LVRC) treatment is an option for selected patients with severe emphysema. In the advanced stages, emphysema leads to respiratory failure: hypoxemia and eventually chronic hypercapnic respi…