Tim Pock
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View article: Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation
Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation Open
The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of …
View article: O-017 A novel diagnostic test identifies patients suffering from loss of CatSper function
O-017 A novel diagnostic test identifies patients suffering from loss of CatSper function Open
Study question Is a loss of CatSper function in sperm a common cause of unexplained male infertility? Summary answer Loss of CatSper function leads to similar infertility phenotypes in mice and men and represents one of the most common cau…
View article: Unexplained infertility is frequently caused by defective CatSper function preventing sperm from penetrating the egg coat
Unexplained infertility is frequently caused by defective CatSper function preventing sperm from penetrating the egg coat Open
The infertility of many couples seems to rest on an enigmatic dysfunction of the men’s sperm, rendering early diagnosis and evidence-based treatment by medically assisted reproduction impossible. Using a novel laboratory test, we assessed …
View article: GM-CSF perturbs cell identity in mouse pre-implantation embryos
GM-CSF perturbs cell identity in mouse pre-implantation embryos Open
Growth factors became attractive candidates for medium supplementation to further improve the quality of embryo culture and to mimic in vivo nutrition. Granulocyte macrophage colony-stimulating factor (GM-CSF) is a cytokine influencing the…
View article: The C-X-C signalling system in the rodent vs primate testis: impact on germ cell niche interaction
The C-X-C signalling system in the rodent vs primate testis: impact on germ cell niche interaction Open
In zebrafish, action of the chemokine Cxcl12 is mediated through its G-protein-coupled seven-transmembrane domain receptor Cxcr4 and the atypical receptor Cxcr7. Employing this animal model, it was revealed that this Cxcl12 signalling syst…
View article: A diagnostic germ cell score for immature testicular tissue at risk of germ cell loss
A diagnostic germ cell score for immature testicular tissue at risk of germ cell loss Open
This study was supported by the Funding Initiative: Translational Research, Ministry of Innovation, Science and Research, Federal State of North Rhine Westphalia (z1403ts006). The authors declare that they do not have competing financial i…