Tim Ruhl
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View article: Profiling of inflammatory and anti-inflammatory cytokines in osteomyelitic bone tissue
Profiling of inflammatory and anti-inflammatory cytokines in osteomyelitic bone tissue Open
Objectives Osteomyelitis (OM) represents a major clinical challenge in reconstructive surgery. It is characterized by chronic infection, impaired healing, and high treatment costs. Despite the high relevance, the local immune and regenerat…
View article: A chronic low dose of Δ9-tetrahydrocannabinol (3 mg / kg / 21 d) reorganizes the disturbed wound healing process and accelerates wound closure in old female mice
A chronic low dose of Δ9-tetrahydrocannabinol (3 mg / kg / 21 d) reorganizes the disturbed wound healing process and accelerates wound closure in old female mice Open
Wound healing in old mice is characterized by disturbed tissue homeostasis, manifested by delayed immune cell infiltration and reduced growth factor secretion, leading to a delayed onset and prolonged duration of the inflammatory phase. Th…
View article: ∆9-Tetrahydrocannabinol Increases Growth Factor Release by Cultured Adipose Stem Cells and Adipose Tissue in vivo
∆9-Tetrahydrocannabinol Increases Growth Factor Release by Cultured Adipose Stem Cells and Adipose Tissue in vivo Open
BACKGROUND: Because of its biocompatibility and its soft and dynamic nature, the grafting of adipose tissue is regarded an ideal technique for soft-tissue repair. The adipose stem cells (ASCs) contribute significantly to the regenerative p…
View article: Delayed cutaneous wound healing in young and old female mice is associated with differential growth factor release but not inflammatory cytokine secretion
Delayed cutaneous wound healing in young and old female mice is associated with differential growth factor release but not inflammatory cytokine secretion Open
The capacity for tissue repair during wound healing declines with age. A chronic low but systemic inflammatory status, often called “inflammaging”, is considered a key factor that contributes to impaired tissue regeneration. This phenomeno…
View article: Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice
Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice Open
Background Adipocytokines play a pivotal role in maintaining adipose tissue homeostasis by regulating cellular metabolism, proliferation, differentiation, and secretory activity. These soluble factors are relevant components for healthy ad…
View article: Effects of cannabinoid receptor activation on <i>Porphyromonas gingivalis</i> lipopolysaccharide stimulation in human periodontal ligament stem cells <i>in vitro</i>
Effects of cannabinoid receptor activation on <i>Porphyromonas gingivalis</i> lipopolysaccharide stimulation in human periodontal ligament stem cells <i>in vitro</i> Open
This study clarifies the effects of specific CB receptor activation on hPDLCs and the inflammatory phenotype. Stimulation of the endocannabinoid system through the manipulation of endogenous or the application of exogenous cannabinoids in …
View article: Antiseptic management of critical wounds: differential bacterial response upon exposure to antiseptics and first insights into antiseptic/phage interactions
Antiseptic management of critical wounds: differential bacterial response upon exposure to antiseptics and first insights into antiseptic/phage interactions Open
Background: With the antibiotic crisis, the topical antibacterial control including chronic wounds gains increasing importance. However, little is known regarding tolerance development when bacteria face repetitive exposure to the identica…
View article: Association between Donor Age and Osteogenic Potential of Human Adipose Stem Cells in Bone Tissue Engineering
Association between Donor Age and Osteogenic Potential of Human Adipose Stem Cells in Bone Tissue Engineering Open
Adipose stem cells (ASCs) have multilineage differentiation capacity and hold great potential for regenerative medicine. Compared to bone marrow-derived mesenchymal stem cells (bmMSCs), ASCs are easier to isolate from abundant sources with…
View article: Association between Donor Age and Osteogenic Potential of Human Adipose Stem Cells in Bone Tissue Engineering
Association between Donor Age and Osteogenic Potential of Human Adipose Stem Cells in Bone Tissue Engineering Open
Adipose stem cells (ASCs) have multilineage differentiation capacity and hold great potential for regenerative medicine. Compared to bone-marrow-derived mesenchymal stem cells (bmMSCs), ASCs are easier to isolate from abundant sources with…
View article: <scp>ITIH5</scp> inhibits proliferation, adipogenic differentiation, and secretion of inflammatory cytokines of human adipose stem cells—A new key in treating obesity?
<span>ITIH5</span> inhibits proliferation, adipogenic differentiation, and secretion of inflammatory cytokines of human adipose stem cells—A new key in treating obesity? Open
Inter‐α‐trypsin inhibitor heavy chain 5 (ITIH5) is widely expressed in the human body, and it is detected to be particularly abundant in adipose tissue. ITIH5 expression is increased in people with obesity compared to lean persons and is d…
View article: Impact of a High-Fat Diet at a Young Age on Wound Healing in Mice
Impact of a High-Fat Diet at a Young Age on Wound Healing in Mice Open
As the prevalence of juvenile-onset obesity rises globally, the multitude of related health consequences gain significant importance. In this context, obesity is associated with impaired cutaneous wound healing. In experimental settings, m…
View article: Adipose and lipoma stem cells: A donor‐matched comparison
Adipose and lipoma stem cells: A donor‐matched comparison Open
Lipomas are slow growing benign fat tumors that develop in soft tissues of the mesoderm. Thus, the specific (dys‐)function of mesenchymal stem cells (MSCs) has been suggested in the development of lipomas, but details of the tumor pathogen…
View article: The Crosstalk Between Adipose-Derived Stem or Stromal Cells (ASC) and Cancer Cells and ASC-Mediated Effects on Cancer Formation and Progression—ASCs: Safety Hazard or Harmless Source of Tropism?
The Crosstalk Between Adipose-Derived Stem or Stromal Cells (ASC) and Cancer Cells and ASC-Mediated Effects on Cancer Formation and Progression—ASCs: Safety Hazard or Harmless Source of Tropism? Open
Adipose-derived stem or stromal cells (ASCs) possess promising potential in the fields of tissue engineering and regenerative medicine due to their secretory activity, their multilineage differentiation potential, their easy harvest, and t…
View article: The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia
The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia Open
Background: Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells characterized by their strong regenerative potential and low oxygen consumption. Macrophage migration inhibitory factor (MIF) is a multifunctional chemoki…
View article: The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering
The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering Open
Bone regeneration is a complex process that is influenced by tissue interactions, inflammatory responses, and progenitor cells. Diseases, lifestyle, or multiple trauma can disturb fracture healing, which might result in prolonged healing d…
View article: Endocannabinoids increase human adipose stem cell differentiation and growth factor secretion in vitro
Endocannabinoids increase human adipose stem cell differentiation and growth factor secretion in vitro Open
Adipose stem cells (ASCs) possess the capacity to proliferate, to differentiate into various cells types, and they are able to secrete growth factors. These characteristics are supposed to contribute to their potential for regenerative med…
View article: Adipose tissue stem cells in peripheral nerve regeneration— <i>In vitro</i> and <i>in vivo</i>
Adipose tissue stem cells in peripheral nerve regeneration— <i>In vitro</i> and <i>in vivo</i> Open
After peripheral nerve injury, Schwann cells (SCs) are crucially involved in several steps of the subsequent regenerative processes, such as the Wallerian degeneration. They promote lysis and phagocytosis of myelin, secrete numbers of neur…
View article: Warp-Knitted Spacer Fabrics: A Versatile Platform to Generate Fiber-Reinforced Hydrogels for 3D Tissue Engineering
Warp-Knitted Spacer Fabrics: A Versatile Platform to Generate Fiber-Reinforced Hydrogels for 3D Tissue Engineering Open
Mesenchymal stem cells (MSCs) possess huge potential for regenerative medicine. For tissue engineering approaches, scaffolds and hydrogels are routinely used as extracellular matrix (ECM) carriers. The present study investigated the feasib…
View article: The effect of the macrophage migration inhibitory factor (MIF) on excisional wound healing <i>in vivo</i>
The effect of the macrophage migration inhibitory factor (MIF) on excisional wound healing <i>in vivo</i> Open
Background: The macrophage migration inhibitory factor (MIF) has been determined as a cytokine exerting a multitude of effects in inflammation and angiogenesis. Earlier studies have indicated that MIF may also be involved in wound healing …
View article: Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF‐2 in adipose tissue during endotoxemia
Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF‐2 in adipose tissue during endotoxemia Open
Sepsis is a leading cause of death worldwide and recent studies have shown white adipose tissue (WAT) to be an important regulator in septic conditions. In the present study, the role of the inflammatory cytokine macrophage migration inhib…