Tim S. Nawrot
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View article: Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort
Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort Open
Importance Understanding early-life origins of increased body mass is crucial because childhood obesity increases the risk of later development of obesity and related metabolic disorders. Appetite hormones have been investigated in relatio…
View article: Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms
Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms Open
Mercury (Hg), particularly methylmercury (MeHg), is a widespread environmental toxicant linked to early-life cardiometabolic risk. This study examined associations between pre- and postnatal total blood mercury (THg) exposure and cardiomet…
View article: The Effects of Repeated Short-Duration Nature Walks on Stress and Cognitive Function in College Students
The Effects of Repeated Short-Duration Nature Walks on Stress and Cognitive Function in College Students Open
Background: College students face significant stress from academic demands and high pressures, which can contribute to long-term physical and mental health issues. Existing stress-relief strategies are not always immediately available to t…
View article: The impact of greening interventions in school grounds on social behavior and cognitive performance among primary school children
The impact of greening interventions in school grounds on social behavior and cognitive performance among primary school children Open
Background Green spaces have been identified as beneficial for children’s mental health, as well as cognitive performance, however, less is known about the role of biodiversity within these environments. Here, we study the impact of greeni…
View article: Associations between exposure to metals, chlorinated pesticides, and PCBs and differential leukocyte profiles in Flemish adolescents
Associations between exposure to metals, chlorinated pesticides, and PCBs and differential leukocyte profiles in Flemish adolescents Open
Although environmental pollutants are known to affect the immune system, the impact of chemical mixtures on adolescent immune function remains understudied. Adolescence is a critical period for immune maturation, and disruptions during thi…
View article: Infant buccal telomere length: associations with maternal distress in pregnancy and offspring temperament
Infant buccal telomere length: associations with maternal distress in pregnancy and offspring temperament Open
Introduction Telomere length is considered a marker of biological aging, and is shown to be susceptible to exposures during gestational and early life, including maternal psychological distress, and to be connected with temperament. Here, …
View article: Prenatal green space exposure and child’s cognition: mediation by cord blood IGF1 in the ENVIRONAGE birth cohort
Prenatal green space exposure and child’s cognition: mediation by cord blood IGF1 in the ENVIRONAGE birth cohort Open
View article: The association between preschoolers’ retinal microcirculation and the indoor microbial environment: results of the ENVIRONAGE birth cohort
The association between preschoolers’ retinal microcirculation and the indoor microbial environment: results of the ENVIRONAGE birth cohort Open
Early life environmental microbiota may influence normative development. Here, we explore the associations between the residential indoor microbial environment and the retinal microcirculation among preschoolers. We included 177 children a…
View article: Robust metabolomics data normalization across scales and experimental designs
Robust metabolomics data normalization across scales and experimental designs Open
Metabolomics studies employing liquid chromatography-mass spectrometry are affected by signal drift and batch effects, introducing technical variance that impedes biological knowledge discovery. Quality control (QC) sample-based normalizat…
View article: New universal approach for microplastics detection in tissues retains histology and reveals unprecedented quantities in placental samples
New universal approach for microplastics detection in tissues retains histology and reveals unprecedented quantities in placental samples Open
Summary Background Micro- and nanoplastics (MNPs) contamination may pose a significant risk to human health. However, their true impact remains underexplored due to substantial limitations of current analytical methods. Traditional techniq…
View article: The link between prenatal exposure to a chemical mixture, cord blood hormones, and birth weight: an epidemiologic study
The link between prenatal exposure to a chemical mixture, cord blood hormones, and birth weight: an epidemiologic study Open
View article: Ventricular-arterial coupling is preserved in prematurely born 11-year-old children but calls for life-long prevention of hemodynamic deterioration
Ventricular-arterial coupling is preserved in prematurely born 11-year-old children but calls for life-long prevention of hemodynamic deterioration Open
Background: Premature birth disrupts the intra-uterine structural and functional maturation of the left ventricle (LV) and arteries. The study investigated the impact of premature birth on ventricular-arterial coupling (VAC), a potential p…
View article: Evaluation of race-free eGFR equations in individuals of different ethnicity
Evaluation of race-free eGFR equations in individuals of different ethnicity Open
The NHANES mortality outcomes support the use of eGFRcys and eGFRcr-cys. However, large intraindividual variability between eGFR estimates may lead to KDIGO eGFR stage misclassification and calls for caution in the op…
View article: Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study
Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study Open
View article: Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study
Telomere Length and Emotional and Behavioral Problems in Children from the Prospective Birth Cohort INfancia y Medio Ambiente (INMA) Study Open
Background/Objectives: This study aimed to examine the association between leukocyte telomere length (TL) measured at ages 4 and 8 and emotional and behavioral problems at age 8. We also explored whether changes in leukocyte TL between age…
View article: Urinary parabens, advanced glycation end products and blood pressure in children: a longitudinal cohort study
Urinary parabens, advanced glycation end products and blood pressure in children: a longitudinal cohort study Open
View article: Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight
Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight Open
This novel untargeted workflow elucidated biological mechanisms linking environmental exposures to child obesity, potentially supporting targeted public health interventions.
View article: Relative biodistribution and accumulation of carbonaceous nanoparticles inside the murine and human kidney
Relative biodistribution and accumulation of carbonaceous nanoparticles inside the murine and human kidney Open
View article: Telomere length and COVID-19 disease severity: insights from hospitalized patients
Telomere length and COVID-19 disease severity: insights from hospitalized patients Open
Introduction Telomere length is associated with various disease and immune function and may therefore impact COVID-19 disease severity. We studied the associations between telomere length as a geroprotective susceptibility marker and clini…
View article: Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood
Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood Open
Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking and …
View article: Associations of family affluence with cortisol production and telomere length in European children
Associations of family affluence with cortisol production and telomere length in European children Open
UK Research and Innovation (Grants: MR/S03532X/1, MR/Y02012X/1), European Community (Grants: 874583, 308333).
View article: Table S1 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium
Table S1 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium Open
Table S1: Results from the univariate analysis for the glandular tissue (GLAND). For FFTP, we used the proc NLIN procedure, for the others a GLM. Multiplicative estimates provided are calculated according to eβ for the given unit change
View article: Table S3 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium
Table S3 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium Open
Table S3: Results from the univariate ordinal logistic regression model for BI-RADS. The model for FFTP was stratified based on the results from the GLAND and VBD models: ‘≤ 25.7 years’ and ‘> 25.7 years’. Data is presented as Odds Ratio (…
View article: Table S2 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium
Table S2 from Age at First Full-term Pregnancy and Other Reproductive Factors Are Associated with Mammographic Breast Density in Postmenopausal Women: A Study in Flanders, Belgium Open
Table S2: Results from the univariate analysis for the volumetric breast density (VBD). For FFTP, we used the proc NLIN procedure, for the others a GLM. Multiplicative estimates provided are calculated according to eβ for the given unit ch…
View article: Positive impact of the introduction of low-emission zones in Antwerp and Brussels on air quality, socio-economic disparities and health: a quasi-experimental study
Positive impact of the introduction of low-emission zones in Antwerp and Brussels on air quality, socio-economic disparities and health: a quasi-experimental study Open
Low emission zones (LEZ) manage traffic entering cities by granting access only to vehicles that meet certain emission standards. This study evaluated if implementation of LEZs in Antwerp (2017) and Brussels (2018) improved air pollution w…
View article: EVALUATION OF RACE-FREE EGFR EQUATIONS IN INDIVIDUALS OF DIFFERENT ETHNICITY
EVALUATION OF RACE-FREE EGFR EQUATIONS IN INDIVIDUALS OF DIFFERENT ETHNICITY Open
Objective: This study aimed to evaluate the impact of CKD age-defined definition on all-cause mortality and cardiovascular (CV) outcomes in a rural population over 136 months long-term follow-up (2005-2022). Design and method: A total of 1…
View article: BLOOD PRESSURE TRAJECTORY FROM BIRTH TO PRESCHOOL- AND SCHOOL-AGE: EVIDENCE FROM ENVIRONAGE BIRTH COHORT
BLOOD PRESSURE TRAJECTORY FROM BIRTH TO PRESCHOOL- AND SCHOOL-AGE: EVIDENCE FROM ENVIRONAGE BIRTH COHORT Open
Objective: BP measurement devices must demonstrate clinical accuracy proved by proper validation testing in the intended population, following the standards published by the internationally accepted protocols. This review aims to evaluate …
View article: Exposure to green space is associated with higher skin microbiota species richness in children
Exposure to green space is associated with higher skin microbiota species richness in children Open
Skin is the exterior interface of the human body with the environment and harbors millions of microorganisms crucial for skin health. Associations between early-life green space exposure and the skin microbiome of children remain unstudied…
View article: Automated Integration and Quality Assessment of Chromatographic Peaks in LC–MS-Based Metabolomics and Lipidomics Using TARDIS
Automated Integration and Quality Assessment of Chromatographic Peaks in LC–MS-Based Metabolomics and Lipidomics Using TARDIS Open
In recent years, liquid chromatography coupled to mass spectrometry (LC-MS) has emerged as the main technology to measure the whole of small molecules (the metabolome) in a diversity of matrices. Within the field of computational metabolom…
View article: Socioeconomic inequalities and ambient air pollution exposure in school-aged children living in an affluent society: an analysis on individual and aggregated data in Belgium
Socioeconomic inequalities and ambient air pollution exposure in school-aged children living in an affluent society: an analysis on individual and aggregated data in Belgium Open
Low neighborhood income was significantly associated with higher levels of air pollution, while parental education level was not significantly associated. Children from parents with a low education and low income were exposed to the highes…