Tim Schindler
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View article: Ursodeoxycholic acid for the treatment of cholestasis in newborn infants
Ursodeoxycholic acid for the treatment of cholestasis in newborn infants Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of ursodeoxycholic acid for the treatment of cholestasis in newborn infants.
View article: International Variation and Trends of Intraventricular Hemorrhage in Very Preterm Infants
International Variation and Trends of Intraventricular Hemorrhage in Very Preterm Infants Open
Introduction: We aimed to investigate international variation in gestational age (GA) specific severe intraventricular hemorrhage (IVH) rates, among infants of
View article: Targeted Cerebral Oxygenation Using Dedicated Treatment Versus Usual Care in Extremely Preterm Infants: Protocol for a Multicentre International Phase <scp>II</scp> Randomised Controlled Trial
Targeted Cerebral Oxygenation Using Dedicated Treatment Versus Usual Care in Extremely Preterm Infants: Protocol for a Multicentre International Phase <span>II</span> Randomised Controlled Trial Open
Background Near infrared spectroscopy (NIRS) allows continuous monitoring of cerebral oxygenation and therefore has the potential to be neuroprotective. Recurrent episodes of cerebral hypo‐and/or hyperoxia may result in brain injury. The S…
View article: Association between Congenital Anomalies and Late-Onset Bacterial Infections in Neonates Admitted to Neonatal Intensive Care Units in Australia and New Zealand: A Population-Based Cohort Study
Association between Congenital Anomalies and Late-Onset Bacterial Infections in Neonates Admitted to Neonatal Intensive Care Units in Australia and New Zealand: A Population-Based Cohort Study Open
Introduction: Compromised neonatal intensive care unit neonates are at risk of acquiring late-onset infections (late-onset sepsis [LOS]). Neonates born with congenital anomalies (CAs) could have an additional LOS risk. Methods: Utilising t…
View article: Supplementary Material for: International online survey on the management of patent ductus arteriosus
Supplementary Material for: International online survey on the management of patent ductus arteriosus Open
Introduction There is uncertainty and lack of consensus regarding optimal management of patent ductus arteriosus (PDA). We aimed to determine current clinical practice in PDA management across a range of different regions internationally. …
View article: Intermittent phototherapy versus continuous phototherapy for neonatal jaundice
Intermittent phototherapy versus continuous phototherapy for neonatal jaundice Open
We included 12 RCTs (1600 infants) in the review. There is one ongoing study and four awaiting classification. There was little or no difference between intermittent phototherapy and continuous phototherapy with respect to rate of decline …
View article: Reference Values For Diaphragm Electrical Activity (Edi) In Newborn Infants
Reference Values For Diaphragm Electrical Activity (Edi) In Newborn Infants Open
Background: Neurally adjusted ventilatory assist is an emerging mode of respiratory support that uses the electrical activity of the diaphragm (Edi) to provide synchronised inspiratory pressure support, proportional to an infant's changing…
View article: In-utero transmission of SARS CoV-2 infection during delta variant outbreak: first Australian experience
In-utero transmission of SARS CoV-2 infection during delta variant outbreak: first Australian experience Open
Infection with great interest and respond to it with a case of our own that provides further evidence of the potential for in-utero transmission of SARS-CoV-2.Our case occurred during the current outbreak of the Delta variant in Sydney, Au…
View article: Additional file 2 of Reference values for diaphragm electrical activity (Edi) in newborn infants
Additional file 2 of Reference values for diaphragm electrical activity (Edi) in newborn infants Open
Additional file 2.
View article: Reference values for diaphragm electrical activity (Edi) in newborn infants
Reference values for diaphragm electrical activity (Edi) in newborn infants Open
Background: Neurally adjusted ventilatory assist (NAVA) is an emerging mode of respiratory support that uses the electrical activity of the diaphragm (Edi) to provide synchronised inspiratory pressure support, proportional to an infant’s c…
View article: Trial of aerosolised surfactant for preterm infants with respiratory distress syndrome
Trial of aerosolised surfactant for preterm infants with respiratory distress syndrome Open
Objective To evaluate the safety of an aerosolised surfactant, SF-RI 1, administered via nasal continuous positive airway pressure (nCPAP) and a prototype breath synchronisation device (AeroFact), to preterm infants with respiratory distre…
View article: Diaphragm-triggered non-invasive respiratory support in preterm infants
Diaphragm-triggered non-invasive respiratory support in preterm infants Open
Due to limited data and very low certainty evidence, we were unable to determine if diaphragm-triggered non-invasive respiratory support is effective or safe in preventing respiratory failure in preterm infants. Large, adequately powered r…
View article: Standardised neonatal parenteral nutrition formulations – Australasian Neonatal Parenteral Nutrition Consensus update 2017
Standardised neonatal parenteral nutrition formulations – Australasian Neonatal Parenteral Nutrition Consensus update 2017 Open
Background: The first consensus standardised neonatal parenteral nutrition formulations were implemented in many neonatal units in Australia in 2012. The current update involving 49 units from Australia, New Zealand, Singapore, Malaysia an…
View article: Standardised neonatal parenteral nutrition formulations – Australasian Neonatal Parenteral Nutrition Consensus update 2017
Standardised neonatal parenteral nutrition formulations – Australasian Neonatal Parenteral Nutrition Consensus update 2017 Open
Background: The first consensus standardised neonatal parenteral nutrition formulations were implemented in many neonatal units in Australia in 2012. The current update involving 49 units from Australia, New Zealand, Singapore, Malaysia an…
View article: Standardised neonatal parenteral nutrition formulations – Australasian Neonatal Parenteral Nutrition Consensus update 2017
Standardised neonatal parenteral nutrition formulations – Australasian Neonatal Parenteral Nutrition Consensus update 2017 Open
The first consensus standardised neonatal parenteral nutrition formulations were implemented in many neonatal units in Australia in 2012. The current update involving 49 units from Australia, New Zealand, Singapore, Malaysia and India was …
View article: Stopping enteral feeds for prevention of transfusion-associated necrotising enterocolitis in preterm infants
Stopping enteral feeds for prevention of transfusion-associated necrotising enterocolitis in preterm infants Open
Randomised controlled trial evidence is insufficient to show whether stopping feeds has an effect on the incidence of subsequent NEC or death. Large, adequately powered RCTs are needed to address this issue.
View article: Early PARacetamol (EPAR) trial: a study protocol for a randomised controlled trial of early paracetamol to promote closure of the ductus arteriosus in preterm infants
Early PARacetamol (EPAR) trial: a study protocol for a randomised controlled trial of early paracetamol to promote closure of the ductus arteriosus in preterm infants Open
Introduction The optimal management of patent ductus arteriosus (PDA) remains contentious. The medications used to treat PDA are often non-steroidal anti-inflammatory drugs, which are associated with a number of unwanted adverse effects. P…
View article: Survey on Clinical Practice of Parenteral Nutrition in Neonates in Australasia
Survey on Clinical Practice of Parenteral Nutrition in Neonates in Australasia Open
Following the formation of the Neonatal Parental Nutrition Consensus Group in November 2010 and publication of consensus guidelines, many neonatal intensive care units (NICUs) across Australia have begun to implement the use of standardise…
View article: Prediction of outcomes of extremely low gestational age newborns in Australia and New Zealand
Prediction of outcomes of extremely low gestational age newborns in Australia and New Zealand Open
In our recent cohort of extremely preterm infants, the NICHD model does not accurately predict outcomes and is marginally better than gestational age based outcomes.
View article: Early vascular ageing and coupling with deranged cardiac function in preterm fetal growth restricted (FGR) infants
Early vascular ageing and coupling with deranged cardiac function in preterm fetal growth restricted (FGR) infants Open
22 episodes), median Fi02 and CO2 were lower on the first gas after escalation (FiO2 35% vs 30% [p = 0.002]; CO2 64 mmHg vs 52 mmHg [p < 0.001]).When used as a backup for apnoeas, 10 of 11 infants had a reduction in apnoeas associated with…
View article: Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy
Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy Open
There is no evidence that PUFA supplementation in infancy has an effect on infant or childhood allergy, asthma, dermatitis/eczema or food allergy. However, the quality of evidence was very low. There was insufficient evidence to determine …