Tim J. Schulz
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View article: The dorsal aortic compartment is a developmental source of brown adipose tissue in mice
The dorsal aortic compartment is a developmental source of brown adipose tissue in mice Open
White adipose tissue primarily stores energy while brown adipose tissue dissipates energy as heat, holding promise for therapeutic use. Brown adipose tissue in the anterior trunk is believed to derive from the somitic mesoderm, although so…
View article: pubCounteR: an R package for interrogating published literature for experimentally-derived gene lists within a user-defined biological context
pubCounteR: an R package for interrogating published literature for experimentally-derived gene lists within a user-defined biological context Open
Basic and clinical biomedical research relies heavily on modern large-scale datasets that include genomics, transcriptomics, epigenomics, metabolomics, and proteomics, among other “Omics”. These research tools very often generate lists of …
View article: Differential expression of plasma extracellular vesicles microRNAs and exploration of their association with bone metabolism in childhood trauma participants treated in a psychosomatic clinic
Differential expression of plasma extracellular vesicles microRNAs and exploration of their association with bone metabolism in childhood trauma participants treated in a psychosomatic clinic Open
Introduction Early life stress (ELS) impacts neurotransmitters and cell communication, potentially disrupting neurological and physiological processes. Recently, ELS has been implicated in impaired bone metabolism, with extracellular vesic…
View article: Palmitic acid and eicosapentaenoic acid supplementation in 3T3 adipocytes: impact on lipid storage and oxidative stress
Palmitic acid and eicosapentaenoic acid supplementation in 3T3 adipocytes: impact on lipid storage and oxidative stress Open
These results emphasize the contrasting roles of PA and EPA and the importance of fatty acid composition in the regulation of adipocyte function.
View article: Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation
Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation Open
Background The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the developmen…
View article: Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice
Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice Open
Introduction Caloric restriction (CR) is a nutritional intervention that increases life expectancy while lowering the risk for cardio-metabolic disease. Its effects on bone health, however, remain controversial. For instance, CR has been l…
View article: MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution
MarShie: a clearing protocol for 3D analysis of single cells throughout the bone marrow at subcellular resolution Open
Analyzing immune cell interactions in the bone marrow is vital for understanding hematopoiesis and bone homeostasis. Three-dimensional analysis of the complete, intact bone marrow within the cortex of whole long bones remains a challenge, …
View article: Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape
Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape Open
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on the regulation of AT immune infiltration is still elusi…
View article: Aging impairs skeletal muscle regeneration by promoting fibro/fatty degeneration and inhibiting inflammation resolution via fibro-adipogenic progenitors
Aging impairs skeletal muscle regeneration by promoting fibro/fatty degeneration and inhibiting inflammation resolution via fibro-adipogenic progenitors Open
Summary Skeletal muscle regeneration depends on the function of fibro/adipogenic progenitors (FAPs). Here we show that aging impairs myogenic stem cells by disrupting the integration of extracellular matrix and immunomodulatory functions w…
View article: Lipedema stage affects adipocyte hypertrophy, subcutaneous adipose tissue inflammation and interstitial fibrosis
Lipedema stage affects adipocyte hypertrophy, subcutaneous adipose tissue inflammation and interstitial fibrosis Open
Introduction Lipedema is a painful subcutaneous adipose tissue (SAT) disease characterized by adipocyte hypertrophy, immune cell recruitment, and fibrosis in the affected areas. These features are thought to contribute to the development a…
View article: Adipocyte p53 coordinates the response to cyclic fasting by regulating adipose tissue immune cell landscape
Adipocyte p53 coordinates the response to cyclic fasting by regulating adipose tissue immune cell landscape Open
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on the regulation of AT immune infiltration is still elusi…
View article: The benefits of adipocyte metabolism in bone health and regeneration
The benefits of adipocyte metabolism in bone health and regeneration Open
Patients suffering from musculoskeletal diseases must cope with a diminished quality of life and an increased burden on medical expenses. The interaction of immune cells and mesenchymal stromal cells during bone regeneration is one of the …
View article: Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function
Cold-induced expression of a truncated Adenylyl Cyclase 3 acts as rheostat to brown fat function Open
Promoting brown adipose tissue (BAT) activity has been recognized as innovative therapeutic approach to improve obesity and metabolic disease. Whilst the molecular circuitry underlying thermogenic activation of BAT is well understood, the …
View article: p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting
p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting Open
Active thermogenic adipocytes avidly consume energy substrates like fatty acids and glucose to maintain body temperature upon cold exposure. Despite strong evidence for the involvement of brown adipose tissue (BAT) in controlling systemic …
View article: Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling
Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling Open
The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selen…
View article: Distinct Adipogenic and Fibrogenic Differentiation Capacities of Mesenchymal Stromal Cells from Pancreas and White Adipose Tissue
Distinct Adipogenic and Fibrogenic Differentiation Capacities of Mesenchymal Stromal Cells from Pancreas and White Adipose Tissue Open
Pancreatic steatosis associates with β-cell failure and may participate in the development of type-2-diabetes. Our previous studies have shown that diabetes-susceptible mice accumulate more adipocytes in the pancreas than diabetes-resistan…
View article: Complementary Omics Strategies to Dissect p53 Signaling Networks Under Nutrient Stress
Complementary Omics Strategies to Dissect p53 Signaling Networks Under Nutrient Stress Open
Signaling trough p53 is a major cellular stress response mechanism and increases upon nutrient stresses such as starvation. Here, we show in a human hepatoma cell line that starvation leads to robust nuclear p53 stabilization. Using BioID,…