Tim Schutte
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Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records Open
Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 canc…
Stiff-Person Syndrome with Anti-Amphiphysin Antibodies: A Paraneoplastic Phenomenon Revealing Breast Cancer in a 77-Year-Old Male Open
Introduction: Stiff-person syndrome is a neurological disorder characterized by painful muscle cramps and progressive muscle spasticity. In patients with positive anti-amphiphysin antibodies, there is an association with malignancies such …
Real-World Patient Outcomes on the Efficacy of Lanreotide Treatment for Neuroendocrine Tumors: The Influence of Body Mass Index, Body Surface Area, and Renal Function Open
Introduction: Lanreotide is an effective and safe first-line therapy to treat patients with a gastroenteropancreatic (GEP) neuroendocrine tumor (NET). Precision oncology may be used to provide each patient with the right dosage. Pharmacoki…
View article: Access to EU-Authorized Nonreimbursed Anticancer Medicines: An Explorative Survey Among Dutch Medical Oncologists
Access to EU-Authorized Nonreimbursed Anticancer Medicines: An Explorative Survey Among Dutch Medical Oncologists Open
The majority of Dutch medical oncologists encounter EU-authorized, nonreimbursed anticancer medicines and report substantial variation in related practices and ethical views. In the absence of a national access framework, availability ofte…
Improving the usability of grading scales for drug-induced ototoxicity with a focus on real world data collection Open
Purpose Chemotherapy induced ototoxicity (e.g. by cisplatin) is a regularly occurring although underreported challenge in clinical practice. Several reviews of ototoxicity monitoring throughout clinical trials reveal difficulty in estimati…
Comparison of cisplatin-induced hearing loss in different durations of infusion and volume of hydration schedules in head and neck squamous cell carcinoma patients treated with cisplatin-based chemoradiation Open
This study found no significant difference in CIHL between different DIVHS during cisplatin-based chemoradiation in HNSCC patients.
The reporting of ethical review and ethical considerations in articles published in medical education journals: A literature review Open
Background Health professions education research (HPE‐R) must be ethically sound. Ethical review decisions and other ethical considerations should be clearly reported in journal articles to allow readers to assess the ethical soundness of …
Beyond Skin Rash: Alpelisib-Induced Anaphylactic Reactions Open
Alpelisib is a specific oral PI3K inhibitor used combined with fulvestrant for the treatment of patients with HR+/HER2–/PIK3CA-mutated metastatic breast cancer. Adverse drug reactions with alpelisib are common, including hyperglycemia and …
Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review Open
This report summarizes encouraging clinical development of WEE1i in gynecological cancers and considers its application in future studies. Biomarker-driven patient selection might be essential to increase the response rates.
Successful Trastuzumab-Deruxtecan Rechallenge After Interstitial Lung Disease: A Case Report Open
Trastuzumab deruxtecan (T-DXd) is used to treat human epidermal growth factor receptor 2-positive advanced breast cancer. Interstitial lung disease (ILD) is a severe adverse event associated with T-DXd. Current guidelines recommend permane…
Short-term fasting and fasting mimicking diets combined with chemotherapy: a narrative review Open
Many patients with cancer search for and use alternative and complementary treatments, aiming to improve the effectiveness of their anticancer treatment and a reduction in treatment-associated side effects. Short-term fasting (STF) and fas…
The Importance of Context and Organization of Ethical Review in Health Professions Education Research Open
To the Editor: In ten Cate’s Invited Commentary on the ethics of health professions education (HPE) research (HPE-R), 1 he provides 27 lessons in HPE ethics and states the importance of discussions to develop ethical integrity. We believe …
Roses and Balances: A Paradigm for Constructive Ethical Review of Health Professions Education Research Open
Recently, the balance between value and necessity of ethical review of health professions education research has been debated. At present, there are large differences in how ethical review of research proposals for health professions educa…
View article: Ethics approval for health professions education research: Necessary and beneficial
Ethics approval for health professions education research: Necessary and beneficial Open
Editor - Recently, Schuwirth and Durning1 advocated for liberal and limited ethical review for health professions education (HPE)research. They question the value and process of ethical reviewing because of its supposed incapability to ‘de…
Plastic intensive, purpose-built car: Autonomous urban transport in 2029 Open
It is expected that the automotive industry will be facing a radical shift, going from human driven cars to cars that are driving autonomously. In this project I started out with performing an in depth literature research to get a good und…
Essential diseases in prescribing: A national Delphi study towards a core curriculum in pharmacotherapy education Open
Aims Prescribing is a core skill for junior doctors, yet 8–10% of their prescriptions contain errors. To ensure adequate training in prescribing, it is important to define the diseases for which junior doctors should be competent to prescr…
Improving antibiotic prescribing skills in medical students: the effect of e-learning after 6 months Open
E-learning during a limited period can significantly improve medical students' performance of an antimicrobial therapeutic consultation in a situation simulating clinical practice 6 months later.
Opportunities for Students to Prescribe: An Evaluation of 185 Consultations in the Student‐run Cardiovascular Risk Management Programme Open
Involving students in cardiovascular risk management (CVRM) could offer patients a structured CVRM programme and students a valuable learning opportunity. We describe and evaluate a student‐run CVRM programme that was set up to offer prima…