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View article: Regenerative endodontic procedures in immature permanent teeth with pulp necrosis: the impact of microbiology on clinical and radiographic outcome
Regenerative endodontic procedures in immature permanent teeth with pulp necrosis: the impact of microbiology on clinical and radiographic outcome Open
Aims The current study aimed to determine how the disinfection strategy for regenerative endodontic procedures (REPs) influences overall bacterial load and REP outcomes. Different bacterial species in the teeth were also examined in this s…
View article: Glycerol strengthens probiotic effect of <i>Limosilactobacillus reuteri</i> in oral biofilms: A synergistic synbiotic approach
Glycerol strengthens probiotic effect of <i>Limosilactobacillus reuteri</i> in oral biofilms: A synergistic synbiotic approach Open
Both in vitro and in vivo studies have shown that the probiotic Limosilactobacillus reuteri can improve oral health. Limosilactobacillus reuteri species are known to produce the antimicrobial “reuterin” from glycerol. In order to further i…
View article: Assessment of Disinfection Potential of Q-Switch Nd: YAG Laser on Contaminated Titanium Implant Surfaces
Assessment of Disinfection Potential of Q-Switch Nd: YAG Laser on Contaminated Titanium Implant Surfaces Open
Peri-implantitis (PI) is a relatively frequent pathology that compromises the overall survival of the dental implant. Adjunctive approaches for the conventional mechanical debridement are being suggested to optimize the treatment of PI. Th…
View article: Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against Planktonic Porphyromonas gingivalis and Within Multi-Species Biofilm: A Pilot Study
Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against Planktonic Porphyromonas gingivalis and Within Multi-Species Biofilm: A Pilot Study Open
Leucocyte- and platelet rich fibrin (L-PRF) is an autologous biomaterial used in regenerative procedures. It has an antimicrobial activity against P. gingivalis although the mechanism is not fully understood. It was hypothesized that L-PRF…
View article: Differences in chlorhexidine mouthrinses formulations influence the quantitative and qualitative changes in in‐vitro oral biofilms
Differences in chlorhexidine mouthrinses formulations influence the quantitative and qualitative changes in in‐vitro oral biofilms Open
Objective Chlorhexidine mouthrinses are marketed in different formulations. This study aimed at investigating qualitative and quantitative changes in in‐vitro multispecies oral biofilms, induced by different chlorhexidine‐containing mouthr…
View article: Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm
Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm Open
Previous research identified potential prebiotic substrates for oral health like the structural analogues N -acetyl- d -mannosamine (NADM) and N -acetyl- d -glucosamine (NADG). The main hypothesis of the current study was twofold. Firstly,…
View article: In Vitro Multi-Species Oral Biofilms Grown in Presence of H2O2 Production-Affecting Substrates Show Health-Associated Alterations in Composition, Metabolism and Virulence.
In Vitro Multi-Species Oral Biofilms Grown in Presence of H2O2 Production-Affecting Substrates Show Health-Associated Alterations in Composition, Metabolism and Virulence. Open
Modulation of the commensal oral microbiota is a promising preventive or therapeutic strategy for oral health and can for instance be achieved by increasing the abundance and/or activity of certain species. This study evaluated whether 10 …
View article: Evaluating the intrinsic capacity of oral bacteria to produce hydrogen peroxide (H2O2) in liquid cultures: Interference by bacterial growth media
Evaluating the intrinsic capacity of oral bacteria to produce hydrogen peroxide (H2O2) in liquid cultures: Interference by bacterial growth media Open
This work highlights the issue of interference by growth media when measuring bacterial H2O2 production. H2O2 was shown to be stable in phosphate buffered saline (PBS) but not in growth media. The protocol used for evaluating the intrinsic…
View article: Potential prebiotic substrates modulate composition, metabolism, virulence and inflammatory potential of an in vitro multi-species oral biofilm
Potential prebiotic substrates modulate composition, metabolism, virulence and inflammatory potential of an in vitro multi-species oral biofilm Open
Background: Modulation of the commensal oral microbiota constitutes a promising preventive/therapeutic approach in oral healthcare. The use of prebiotics for maintaining/restoring the health-associated homeostasis of the oral microbiota ha…
View article: A Viability Quantitative PCR Dilemma: Are Longer Amplicons Better?
A Viability Quantitative PCR Dilemma: Are Longer Amplicons Better? Open
Viability quantitative PCR (v-qPCR) has evolved into a valuable, mainstream technique for determining the number of viable microorganisms in samples by qPCR. Amplicon length is known to be positively correlated with the ability to distingu…
View article: Q-Switch Nd:YAG Laser-Assisted Elimination of Multi-Species Biofilm on Titanium Surfaces
Q-Switch Nd:YAG Laser-Assisted Elimination of Multi-Species Biofilm on Titanium Surfaces Open
(1) Background: The relatively high prevalence of peri-implantitis (PI) and the lack of a standard method for decontamination of the dental implant surface have pushed us to conduct further research in the field. Bacterial biofilms were fo…
View article: Q-Switch Nd:YAG Laser-Assisted Decontamination of Implant Surface
Q-Switch Nd:YAG Laser-Assisted Decontamination of Implant Surface Open
Peri-implantitis (PI) is an inflammatory disease of peri-implant tissues, it represents the most frequent complication of dental implants. Evidence revealed that microorganisms play the chief role in causing PI. The purpose of our study is…
View article: Terpinen-4-ol and carvacrol affect multi-species biofilm composition
Terpinen-4-ol and carvacrol affect multi-species biofilm composition Open
The aim of this study was to investigate the cytotoxic activity and inhibitory effect of terpinen-4-ol (T4ol) and carvacrol against single- and multi-species biofilms. The toxicity of each compound was tested on oral keratinocytes and eval…
View article: In vitro dysbiotic oral biofilms deregulate the host immune response
In vitro dysbiotic oral biofilms deregulate the host immune response Open
An imbalance in the periodontal microbiota and dysbiosis deregulate the host immune response, leading to chronic inflammation. Since little is k nown about the initiation of dysbiosis, it can be hypothesized that some commensal bacteria ca…