Timm H. Westhoff
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View article: Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome
Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Open
Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to PCS. Quantitative s…
View article: G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles
G protein-coupled receptor autoantibody expression patterns in adults with decelerated biological aging mirror pediatric profiles Open
Background G protein-coupled receptors (GPCRs) represent the largest and most diverse family of membrane proteins. In addition to their endogenous ligands, functional natural autoantibodies (Aab) have also been shown to bind and modulate G…
View article: Association of Serum Uric Acid–Lowering Therapy and Resistance Index After Renal Transplantation
Association of Serum Uric Acid–Lowering Therapy and Resistance Index After Renal Transplantation Open
SUA-lowering therapy is associated with a lower increase of RI over time and a trend to better survival of recipients of renal transplants in this retrospective analysis.
View article: A complex osteoporotic milieu is associated with arterial stiffening and PDGF-BB-mediated calcification of human smooth muscle cells
A complex osteoporotic milieu is associated with arterial stiffening and PDGF-BB-mediated calcification of human smooth muscle cells Open
Accumulating evidence links skeletal and vascular aging, yet the pathological cross-talk between osteoporotic bone and vascular calcification remains insufficiently understood. In this retrospective exploratory study, we show that osteopor…
View article: #1850 The impact of comorbid type 2 diabetes on the prevalence of chronic kidney disease-associated pruritus and its effects on quality of life: data from the CENSUS-EU study
#1850 The impact of comorbid type 2 diabetes on the prevalence of chronic kidney disease-associated pruritus and its effects on quality of life: data from the CENSUS-EU study Open
Background and Aims Chronic kidney disease-associated pruritus (CKD-aP) is common, particularly in patients undergoing haemodialysis, and can impair health-related quality of life (HRQoL). While itch is often observed in patients with diab…
View article: The effects of propionate on blood pressure and arterial function
The effects of propionate on blood pressure and arterial function Open
The short-chain fatty acid propionate has been shown to attenuate atherosclerosis, for example by modulating intestinal cholesterol metabolism. Beyond cholesterol metabolism, data from rodent models suggest a potential additional effect on…
View article: Oromandibular Dystonia and Dysphagia in Hyperglycemic Brainstem Dysfunction
Oromandibular Dystonia and Dysphagia in Hyperglycemic Brainstem Dysfunction Open
Background: Hyperglycemia-induced movement disorders usually present as hemichorea or hemiballismus. Non-choreiform presentations are rare and often overlooked. Case Report: We present the case of a 36-year-old man with uncontrolled type 2…
View article: The impact of age, sex, and comorbidities on COVID-19 mortality of hospitalized patients during the SARS-CoV-2 pandemic: data from the multicentric prospective cohort study of the Lean European Open Survey on SARS-CoV-2 (LEOSS)
The impact of age, sex, and comorbidities on COVID-19 mortality of hospitalized patients during the SARS-CoV-2 pandemic: data from the multicentric prospective cohort study of the Lean European Open Survey on SARS-CoV-2 (LEOSS) Open
Purpose This study aimed to analyse COVID-19-related mortality during the pandemic, stratified by groups at risk of severe COVID-19. Methods Patients with COVID-19 between March 2020 and February 2023 were enrolled using the international …
View article: Case Report: Co-occurrence of tubulitis and SARS-CoV-2 specific T-cells in a kidney transplant recipient
Case Report: Co-occurrence of tubulitis and SARS-CoV-2 specific T-cells in a kidney transplant recipient Open
Background Kidney transplantation is associated with an increased risk of severe COVID-19 disease. Additionally, cells of the kidney express ACE-2 making them a potential target of the SARS-CoV-2 virus. Both uncontrolled viral replication …
View article: Reduced high-density lipoprotein antioxidant function in patients with coronary artery disease and acute coronary syndrome
Reduced high-density lipoprotein antioxidant function in patients with coronary artery disease and acute coronary syndrome Open
HDL function was measured in 2 cohorts: 1225 patients admitted electively for coronary angiography and 196 patients with ACS. A validated cell-free biochemical assay was used to determine reduced HDL antioxidant function, as assessed by in…
View article: Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis
Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis Open
View article: P-1920. The influence of comorbidity, age, sex, and immunosuppression on COVID-19 mortality throughout the course of the SARS-CoV-2 pandemic in Europe: Data from the LEOSS study
P-1920. The influence of comorbidity, age, sex, and immunosuppression on COVID-19 mortality throughout the course of the SARS-CoV-2 pandemic in Europe: Data from the LEOSS study Open
Background Population immunity against SARS-CoV-2 has increased, resulting in a decline of COVID-19 mortality. The aim of the study was to analyse the COVID-19-related mortality over the pandemic, stratified by a model of groups at risk of…
View article: Exploratory testing of functional blood oxygenation level dependent-MRI to image the renoprotective effect of Remote Ischaemic PreConditioning during partial nephrectomy
Exploratory testing of functional blood oxygenation level dependent-MRI to image the renoprotective effect of Remote Ischaemic PreConditioning during partial nephrectomy Open
View article: Combined Administration of Metformin and Propionate Reduces the Degree of Oxidative/Nitrosative Damage of Hypothalamic Neurons in Rat Model of Type 2 Diabetes Mellitus
Combined Administration of Metformin and Propionate Reduces the Degree of Oxidative/Nitrosative Damage of Hypothalamic Neurons in Rat Model of Type 2 Diabetes Mellitus Open
Many complications associated with type 2 diabetes mellitus (T2DM) are closely linked with the generation of reactive species or free radicals leading to oxidative/nitrosative stress. The aim of this study was to investigate the effect of …
View article: Effects of switching from twice-daily tacrolimus to once-daily extended-release meltdose tacrolimus on cellular immune response
Effects of switching from twice-daily tacrolimus to once-daily extended-release meltdose tacrolimus on cellular immune response Open
Background LCP-Tacro [LCPT], a novel once-daily, extended-release formulation of tacrolimus, has a reduced C max with comparable AUC exposure, requiring a ∼30% dose reduction in contrast to immediate-release tacrolimus (IR-Tac). Once-daily…
View article: Propionic acid supplementation promotes the expansion of regulatory T cells in patients with end-stage renal disease but not in renal transplant patients
Propionic acid supplementation promotes the expansion of regulatory T cells in patients with end-stage renal disease but not in renal transplant patients Open
In a previous study, we showed an anti-inflammatory effect of propionic acid supplementation in dialysis patients. The present study intends to analyze the effect of propionic acid on the chronic inflammatory state and T-cell composition i…
View article: Arteriovenous oscillometric plethysmography for fistula functional testing
Arteriovenous oscillometric plethysmography for fistula functional testing Open
The aim of the presented prospective observational study was to evaluate the effect of fistula flow on peripheral wave morphology and pulse wave velocity by means of the oscillometric Vicorder®-device with the purpose of fistula surveillan…
View article: Interactions of TTV with BKV, CMV, EBV, and HHV-6A and their impact on post-transplant graft function in kidney transplant recipients
Interactions of TTV with BKV, CMV, EBV, and HHV-6A and their impact on post-transplant graft function in kidney transplant recipients Open
Background Mono and combined reactivation of latent viruses occurs frequently under immunosuppressive therapy in kidney transplant patients. Recently, monitoring torque teno virus (TTV) reactivation came more into focus as a potential biom…
View article: Urinary calprotectin as a diagnostic tool for detecting significant bacteriuria
Urinary calprotectin as a diagnostic tool for detecting significant bacteriuria Open
Pyuria in dipstick examination serves as the most widespread screening tool for urinary tract infections (UTI). The absence of pyuria, however, does not exclude UTI. We investigated the diagnostic value of urinary calprotectin, a mediator …
View article: Prevalence of masked hypertension in attended versus unattended office blood pressure measurement
Prevalence of masked hypertension in attended versus unattended office blood pressure measurement Open
There is a controversial debate regarding whether unattended blood pressure (BP) measurement should be regarded as the new gold standard of office BP measurement. Unattended BP measurement eliminates the white‐coat effect and reduces exter…
View article: Impact of the COVID-19 pandemic on hospital admission rates for arterial hypertension and coronary heart disease: a German database study
Impact of the COVID-19 pandemic on hospital admission rates for arterial hypertension and coronary heart disease: a German database study Open
Background During the SARS-CoV-2 pandemic it was speculated that the virus might be associated with a persistent increase of cardiovascular risk. The present study compares pre- and post-pandemic hospital admission rates for hypertension a…
View article: #802 CENSUS-EU: a cross-sectional, study to assess the prevalence and burden of chronic kidney disease-associated pruritus in Europe
#802 CENSUS-EU: a cross-sectional, study to assess the prevalence and burden of chronic kidney disease-associated pruritus in Europe Open
Background and Aims Chronic kidney disease-associated pruritus (CKD-aP) is a common condition that can negatively affect patients’ health-related quality of life (HRQoL). Despite this, there has been a lack of clarity on its prevalence and…
View article: Three-Year Mortality of Older Hospitalized Patients with Osteosarcopenia: Data from the OsteoSys Study
Three-Year Mortality of Older Hospitalized Patients with Osteosarcopenia: Data from the OsteoSys Study Open
Osteosarcopenia, the concurrent presence of sarcopenia and osteopenia/osteoporosis, poses a significant health risk to older adults, yet its impact on clinical outcomes is not fully understood. The aim of this prospective, longitudinal mul…
View article: Predictors of blood pressure response to continuous positive airway pressure treatment in patients with sleep apnea
Predictors of blood pressure response to continuous positive airway pressure treatment in patients with sleep apnea Open
Background: Sleep apnea is associated with hypertension. Metaanalyses indicate that treatment of sleep apnea by continuous positive airway pressure (CPAP) reduces blood pressure (BP) by a mean of 3 mmHg. To date, predictors of BP response …
View article: Increased <scp>SARS‐CoV</scp> ‐2 reactive low avidity T cells producing inflammatory cytokines in pediatric post‐acute <scp>COVID</scp> ‐19 sequelae ( <scp>PASC</scp> )
Increased <span>SARS‐CoV</span> ‐2 reactive low avidity T cells producing inflammatory cytokines in pediatric post‐acute <span>COVID</span> ‐19 sequelae ( <span>PASC</span> ) Open
Background A proportion of the convalescent SARS‐CoV‐2 pediatric population presents nonspecific symptoms, mental health problems, and a reduction in quality of life similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) an…
View article: Oxidized high-density lipoprotein associates with atrial fibrillation
Oxidized high-density lipoprotein associates with atrial fibrillation Open
View article: Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents
Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents Open
View article: Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused millions of COVID-19 cases and deaths worldwide. Severity of pulmonary pathologies and poor prognosis were reported to be associated with the activation non-virus-specific…
View article: Plasma NGAL levels in stable kidney transplant recipients and the risk of allograft loss
Plasma NGAL levels in stable kidney transplant recipients and the risk of allograft loss Open
Background The objective of this study was to investigate the utility of neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin (CPT) to predict long-term graft survival in stable kidney transplant recipients (KTR). Methods A t…
View article: Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC)
Increased SARS-CoV-2 reactive low avidity T cells producing inflammatory cytokines in pediatric post-acute COVID-19 sequelae (PASC) Open
Background: A proportion of the convalescent SARS-CoV-2 pediatric population presents nonspecific symptoms, mental health problems and a reduction in quality of life similar to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) an…