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View article: Three‐Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging—A Novel Image Fusion Method
Three‐Dimensional Presentation of Tongue Squamous Cell Carcinoma Histopathology and Magnetic Resonance Imaging—A Novel Image Fusion Method Open
Background Three‐dimensional (3D) modeling has been used in the management of bony head and neck tumors, but not in soft tissue tumors. Currently, histopathological findings of oral squamous cell carcinomas (OSCC) are presented as two‐dime…
View article: Clinical Decision-Making and Risk of Malignancy when Parotid Gland Fine Needle Aspiration Cytology Indicates a Non-Neoplastic or Non-Diagnostic Finding
Clinical Decision-Making and Risk of Malignancy when Parotid Gland Fine Needle Aspiration Cytology Indicates a Non-Neoplastic or Non-Diagnostic Finding Open
Introduction: Non-neoplastic and non-diagnostic cytological findings present a diagnostic and therapeutic challenge in head and neck oncology. Both groups still harbor a risk of malignancy (ROM). Of note, ROM values have been counted from …
View article: Ultrasound-enhanced fine-needle biopsy improves tissue yield in head and neck tumors ex vivo
Ultrasound-enhanced fine-needle biopsy improves tissue yield in head and neck tumors ex vivo Open
Current needle biopsy techniques, i.e., fine-needle aspiration biopsy (FNAB) and core needle biopsy (CNB), are widely utilized in cancer diagnostics but have certain shortcomings. The limited yield of diagnostic cellular material and the l…
View article: Expression of toll‐like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma
Expression of toll‐like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma Open
Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll‐like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour …
View article: Toll-like receptors 2 and 4, and bacterial proteins in IgG4-related sialadenitis, other types of chronic sialadenitis and sialolithiasis
Toll-like receptors 2 and 4, and bacterial proteins in IgG4-related sialadenitis, other types of chronic sialadenitis and sialolithiasis Open
A stronger TLR2 or TLR4 expression in IgG4-positive sialadenitis may indicate a tissue-related factor underlying this form of chronic sialadenitis. LPS- and P. gingivalis immunopositivity remained weak throughout this series. Thus, gram-ne…
View article: Viral DNA in submandibular gland tissue with an inflammatory disorder
Viral DNA in submandibular gland tissue with an inflammatory disorder Open
None of the studied viruses are implicated as triggering IgG4-overexpression in CS. Although our results do not confirm viral etiology in the examined conditions, they provide valuable information on the prevalence of viruses in both disea…
View article: Clinical decision making when cytology indicates a Warthin tumor
Clinical decision making when cytology indicates a Warthin tumor Open
Warthin tumor (WT) is a benign tumor usually affecting the parotid gland. The main diagnostic tool remains ultrasound combined with fine-needle aspiration cytology (FNAC). This study aims to examine how reliably FNAC indicates WT for clini…
View article: Psychosocial factors and patient and healthcare delays in large (class T3–T4) oral, oropharyngeal, and laryngeal carcinomas
Psychosocial factors and patient and healthcare delays in large (class T3–T4) oral, oropharyngeal, and laryngeal carcinomas Open
Background: Psychosocial factors and socioeconomic status have been associated with incidence, survival, and quality of life among patients with head and neck cancer. We investigated the association between different psychosocial factors, …
View article: Ultrasound-guided bleomycin sclerotherapy for Warthin’s tumor: preliminary results of a prospective study
Ultrasound-guided bleomycin sclerotherapy for Warthin’s tumor: preliminary results of a prospective study Open
Background Warthin’s tumor (WT) is the second most common parotid gland neoplasm with rising incidence. As some WT patients are not suitable for surgery, non-surgical treatment options are needed. This is the first study to evaluate the fe…
View article: PET-CT detection of local residual laryngeal carcinoma after definitive (chemo)radiotherapy
PET-CT detection of local residual laryngeal carcinoma after definitive (chemo)radiotherapy Open
Background Positron emission tomography and computed tomography (PET-CT) is currently recommended in evaluating the treatment response after (chemo)radiotherapy ([C]RT). In the larynx, post-treatment changes and physiological uptake make i…
View article: Prognostic Role of<i>Porphyromonas gingivalis</i>Gingipain Rgp and Matrix Metalloproteinase 9 in Oropharyngeal Squamous Cell Carcinoma
Prognostic Role of<i>Porphyromonas gingivalis</i>Gingipain Rgp and Matrix Metalloproteinase 9 in Oropharyngeal Squamous Cell Carcinoma Open
Our results suggest that tumoral MMP-9 may be related to poor outcome in OPSCC, especially in HPV-negative disease, while Rgp immunoexpression in inflammatory cells is associated here with better disease-specific survival (DSS).
View article: Complications in lymph node excision in the head and neck area
Complications in lymph node excision in the head and neck area Open
Surgical complications after LNE in the head and neck area are rare and mostly minor. Needle biopsy is often recommended preoperatively to avoid unnecessary operations and to refrain performing LNE for patients with non-lymphatic malignanc…
View article: IgG4-positive plasma cells in nonspecific sialadenitis and sialolithiasis
IgG4-positive plasma cells in nonspecific sialadenitis and sialolithiasis Open
Chronic sclerosing sialadenitis is commonly regarded as a manifestation of IgG4-related disease. We previously found that a high IgG4 expression or IgG4-related disease could accompany nonspecific sialadenitis, whereas chronic sclerosing s…
View article: Ear canal and middle-ear tumors: a single-institution series of 87 patients
Ear canal and middle-ear tumors: a single-institution series of 87 patients Open
EAC and MES tumors show great diagnostic and histologic heterogeneity with need for individualized investigative and treatment approaches. In benign tumors, we advocate aggressive local surgical control without sacrificing vital structures…
View article: The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas
The presence of herpesviruses in malignant but not in benign or recurrent pleomorphic adenomas Open
BACKGROUND: The etiology of salivary gland tumors is mainly unknown. The anatomical location of the salivary glands, with the mucosal pathway to the oral cavity and its rich microbiome, raises the question of potential viral background. OB…
View article: Prognostic Value of Apparent Diffusion Coefficient in Oropharyngeal Carcinoma
Prognostic Value of Apparent Diffusion Coefficient in Oropharyngeal Carcinoma Open
Purpose To investigate clinical and radiological factors predicting worse outcome after (chemo)radiotherapy ([C]RT) in oropharyngeal squamous cell carcinoma (OPSCC) with a focus on apparent diffusion coefficient (ADC). Methods This retrosp…
View article: Additive Manufacturing of Resected Oral and Oropharyngeal Tissue: A Pilot Study
Additive Manufacturing of Resected Oral and Oropharyngeal Tissue: A Pilot Study Open
Better visualization of tumor structure and orientation are needed in the postoperative setting. We aimed to assess the feasibility of a system in which oral and oropharyngeal tumors are resected, photographed, 3D modeled, and printed usin…
View article: Three-Dimensional Presentation of Tumor Histopathology: A Model Using Tongue Squamous Cell Carcinoma
Three-Dimensional Presentation of Tumor Histopathology: A Model Using Tongue Squamous Cell Carcinoma Open
Medical imaging often presents objects in three-dimensional (3D) form to provide better visual understanding. In contrast, histopathology is typically presented as two-dimensional (2D). Our objective was to present the tumor dimensions in …
View article: Expression and Role of E-Cadherin, β-Catenin, and Vimentin in Human Papillomavirus–Positive and Human Papillomavirus–Negative Oropharyngeal Squamous Cell Carcinoma
Expression and Role of E-Cadherin, β-Catenin, and Vimentin in Human Papillomavirus–Positive and Human Papillomavirus–Negative Oropharyngeal Squamous Cell Carcinoma Open
Oropharyngeal squamous cell carcinoma (OPSCC) is subclassified by the World Health Organization into two different entities: human papillomavirus (HPV)-positive and HPV-negative tumors. HPV infection promotes the epithelial-to-mesenchymal …
View article: Challenges in diagnosing head and neck cancer in primary health care
Challenges in diagnosing head and neck cancer in primary health care Open
Despite the low incidence of HNC and the large number of patients presenting with HNC-related symptoms, GPs working in PHC sort out potential HNC patients from the general patient group in most cases remarkably effectively. KEY MESSAGES Fo…
View article: Preoperative evaluation and treatment consideration of parotid gland tumors
Preoperative evaluation and treatment consideration of parotid gland tumors Open
Background The nature of parotid tumors often remains unknown preoperatively and final histopathology may reveal unexpected malignancy. Still, the use of fine‐needle aspiration cytology (FNAC) and imaging varies in the management of these …
View article: Factors influencing patient and health care delays in Oropharyngeal Cancer
Factors influencing patient and health care delays in Oropharyngeal Cancer Open
Background The incidence of human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Patients with HPV-associated and HPV-unassociated OPSCC differ in many aspects, which may also impact their diag…
View article: Additional file 1 of Factors influencing patient and health care delays in Oropharyngeal Cancer
Additional file 1 of Factors influencing patient and health care delays in Oropharyngeal Cancer Open
Additional file 1: Table 7. Patients who received palliative treatment