Timo Hamers
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View article: Determination of Chemical Mixtures in Environmental, Food, and Human Samples Using High-Resolution Mass Spectrometry-Based Suspect Screening Approaches
Determination of Chemical Mixtures in Environmental, Food, and Human Samples Using High-Resolution Mass Spectrometry-Based Suspect Screening Approaches Open
Chemical contaminants are widely dispersed in the environment in all its dimensions, posing significant public health problems. Comprehensive knowledge of these stressors is a prerequisite for assessing the associated risk and implementing…
View article: <i>In vitro</i> human brain barrier models for studying thyroid hormone transport
<i>In vitro</i> human brain barrier models for studying thyroid hormone transport Open
Early brain development is dependent on the supply of thyroid hormone (TH) to the fetal brain. Disruption of TH concentrations in early brain development is associated with lower IQ and delayed motor development in children. How TH system …
View article: Chain length and chlorine position affect biotransformation of chlorinated paraffins in an in vitro hepatic model
Chain length and chlorine position affect biotransformation of chlorinated paraffins in an in vitro hepatic model Open
Chlorinated paraffins (CPs) are emerging environmental contaminants with limited biotransformation data because of the complexity of CP technical mixtures and the lack of single congener standards. In this study, novel single CP congeners,…
View article: Informing the decision-making process for potential PMT/vPvM chemicals through the adoption of a risk-based prioritization framework: the ZeroPM approach
Informing the decision-making process for potential PMT/vPvM chemicals through the adoption of a risk-based prioritization framework: the ZeroPM approach Open
A risk-based strategy is presented aimed at prioritizing chemicals screened as potential persistent, mobile and toxic (PMT) or very persistent and very mobile (vPvM) substances. Prioritization is done to strengthen the decision-making proc…
View article: Identification of polar bioactive substances in the Upper Rhine using effect-directed analysis
Identification of polar bioactive substances in the Upper Rhine using effect-directed analysis Open
Effect-Directed Analysis (EDA) was used to identify bioactive compounds in surface and well water from the Upper Rhine, and to evaluate their properties against the criteria set for Persistent, Mobile and Toxic (PMT) and very persistent an…
View article: Profiling the endocrine-disrupting properties of triazines, triazoles, and short-chain PFAS
Profiling the endocrine-disrupting properties of triazines, triazoles, and short-chain PFAS Open
Persistent, mobile, and toxic compounds released to the environment are likely to pollute drinking water sources due to their slow environmental degradation (persistency) and high water solubility (mobility). The aim of the present study w…
View article: Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin
Optimized methods for measuring competitive binding of chemical substances to thyroid hormone distributor proteins transthyretin and thyroxine binding globulin Open
Transthyretin (TTR) and thyroxine-binding globulin (TBG) are two major thyroid hormone (TH) distributor proteins in human plasma, playing important roles in stabilizing the TH levels in plasma, delivery of TH to target tissues, and trans-b…
View article: Passive sampler housing and sorbent type determine aquatic micropollutant adsorption and subsequent bioassay responses
Passive sampler housing and sorbent type determine aquatic micropollutant adsorption and subsequent bioassay responses Open
The combination of integrative passive sampling and bioassays is a promising approach for monitoring the toxicity of polar organic contaminants in aquatic environments. However, the design of integrative passive samplers can affect the acc…
View article: 3,3′,5-Triiodothyroacetic Acid Transporters
3,3′,5-Triiodothyroacetic Acid Transporters Open
Introduction: Thyroid hormone transporters are essential for thyroid hormones to enter target cells. Monocarboxylate transporter (MCT) 8 is a key transporter and is expressed at the blood-brain barrier (BBB), in neural cells and many other…
View article: Effect-Directed Analysis Based on Transthyretin Binding Activity of Per- and Polyfluoroalkyl Substances in a Contaminated Sediment Extract
Effect-Directed Analysis Based on Transthyretin Binding Activity of Per- and Polyfluoroalkyl Substances in a Contaminated Sediment Extract Open
Only a fraction of the total number of per- and polyfluoroalkyl substances (PFAS) are monitored on a routine basis using targeted chemical analyses. We report on an approach toward identifying bioactive substances in environmental samples …
View article: Physiology-informed toxicokinetic model for the zebrafish embryo test developed for bisphenols
Physiology-informed toxicokinetic model for the zebrafish embryo test developed for bisphenols Open
Zebrafish embryos (ZFE) is a widely used model organism, employed in various research fields including toxicology to assess e.g., developmental toxicity and endocrine disruption. Variation in effects between chemicals are difficult to comp…
View article: The contribution of PFAS to thyroid hormone-displacing activity in Dutch waters: A comparison between two in vitro bioassays with chemical analysis
The contribution of PFAS to thyroid hormone-displacing activity in Dutch waters: A comparison between two in vitro bioassays with chemical analysis Open
Per- and polyfluoroalkyl substances (PFAS) are a group of xenobiotics that are widely distributed throughout the aquatic environment. Many PFAS are possible thyroid hormone (TH) system disrupting compounds, because they have the capacity t…
View article: New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project
New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project Open
Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands …
View article: Electrochemical Oxidation for Treatment of PFAS in Contaminated Water and Fractionated Foam─A Pilot-Scale Study
Electrochemical Oxidation for Treatment of PFAS in Contaminated Water and Fractionated Foam─A Pilot-Scale Study Open
Per- and polyfluoroalkyl substances (PFAS) are persistent synthetic contaminants that are present globally in water and are exceptionally difficult to remove during conventional water treatment processes. Here, we demonstrate a practical t…
View article: Regulatory Risk Assessment of Pharmaceuticals in the Environment: Current Practice and Future Priorities
Regulatory Risk Assessment of Pharmaceuticals in the Environment: Current Practice and Future Priorities Open
How can data on the occurrence of pharmaceuticals and personal care products (PPCPs) in the environment and the quality of ecosystems exposed to PPCPs be used to determine whether current regulatory risk assessment schemes are effective? T…
View article: S71 | CECSCREEN | HBM4EU CECscreen: Screening List for Chemicals of Emerging Concern Plus Metadata and Predicted Phase 1 Metabolites
S71 | CECSCREEN | HBM4EU CECscreen: Screening List for Chemicals of Emerging Concern Plus Metadata and Predicted Phase 1 Metabolites Open
HBM4EU CECscreen is a suspect screening list for Chemicals of Emerging Concern (CECs) plus metadata and predicted Phase 1 metabolites. CECScreen is part of the HBM4EU project (coord. UBA) > WP16 "emerging chemicals" (lead INRA, JP Antignac…
View article: S71 | CECSCREEN | HBM4EU CECscreen: Screening List for Chemicals of Emerging Concern Plus Metadata and Predicted Phase 1 Metabolites
S71 | CECSCREEN | HBM4EU CECscreen: Screening List for Chemicals of Emerging Concern Plus Metadata and Predicted Phase 1 Metabolites Open
HBM4EU CECscreen is a suspect screening list for Chemicals of Emerging Concern (CECs) plus metadata and predicted Phase 1 metabolites. CECScreen is part of the HBM4EU project (coord. UBA) > WP16 "emerging chemicals" (lead INRA, JP Antignac…
View article: Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project
Mixture Risk Assessment of Complex Real-Life Mixtures—The PANORAMIX Project Open
Humans are involuntarily exposed to hundreds of chemicals that either contaminate our environment and food or are added intentionally to our daily products. These complex mixtures of chemicals may pose a risk to human health. One of the go…