Timo Jenne
YOU?
Author Swipe
View article: Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides Open
The hexameric AAA+ protein ClpC, combined with peptidase ClpP, forms a critical ATP-dependent protease in bacteria, essential for virulence. ClpC is usually repressed in an inactive resting state, where two ClpC spirals interact via coiled…
View article: Structure of the central <i>Staphylococcus aureus</i> AAA+ protease MecA/ClpC/ClpP
Structure of the central <i>Staphylococcus aureus</i> AAA+ protease MecA/ClpC/ClpP Open
Bacterial AAA+ proteases are composed of a AAA+ partner (e.g. ClpC) and an associated peptidase (e.g. ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence. C…
View article: Structural basis of aggregate binding by the AAA+ disaggregase ClpG
Structural basis of aggregate binding by the AAA+ disaggregase ClpG Open
Severe heat stress causes massive loss of essential proteins by aggregation necessitating a cellular activity that rescues aggregated proteins. This activity is executed by ATP-dependent, ring-forming, hexameric AAA+ disaggregases. Little …