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View article: Downregulation of an NfsA-like nitroreductase causes metronidazole resistance in Gardnerella vaginalis
Downregulation of an NfsA-like nitroreductase causes metronidazole resistance in Gardnerella vaginalis Open
The facultatively anaerobic or microaerophilic bacteria of the genus Gardnerella are the most common species associated with bacterial vaginosis (BV). The treatment of BV is greatly complicated by the high rates of resistance to metronidaz…
View article: Endolysin selectively kills Gardnerella ex vivo in vaginal samples from women with bacterial vaginosis
Endolysin selectively kills Gardnerella ex vivo in vaginal samples from women with bacterial vaginosis Open
Current treatments for bacterial vaginosis (BV) often result in recurrent disease. Gardnerella , a key player in BV pathogenesis, forms biofilms on vaginal epithelial cells. Recombinant endolysins have shown to specifically kill Gardnerell…
View article: Discovery of potent endolysins against Pseudomonas aeruginosa and other gram-negative ESKAPE pathogens by an agar-based screening method
Discovery of potent endolysins against Pseudomonas aeruginosa and other gram-negative ESKAPE pathogens by an agar-based screening method Open
Antibiotic resistance is a growing concern, and there is an urgent need for alternative treatments. A proposed solution includes endolysins. Naturally occurring endolysins have limited activity against Gram-negative bacteria due to the pre…
View article: Evaluation of Metronidazole Resistance of Vaginal Swab Isolates from South African Women Treated for Bacterial Vaginosis
Evaluation of Metronidazole Resistance of Vaginal Swab Isolates from South African Women Treated for Bacterial Vaginosis Open
Background/Objectives: The high recurrence rate of bacterial vaginosis (BV) after antibiotic treatment is at least partially attributed to resistant bacteria. The CAPRISA 083 (CAP083) study investigated the influence of metronidazole (MTZ)…
View article: Preclinical Data on the <i>Gardnerella</i> -Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance of Resistance
Preclinical Data on the <i>Gardnerella</i> -Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance of Resistance Open
Antibiotics are the mainstay of therapy for bacterial vaginosis (BV). However, the rate of treatment failure in patients with recurrent BV is about 50%.
View article: Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo
Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo Open
Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome and a characteristic biofilm formed on the vaginal epithelium, which is initiated and dominated by Gardnerella bacteria, and is frequently refractory to antibio…
View article: Engineered phage endolysin eliminates <i>Gardnerella</i> in bacterial vaginosis without damaging the healthy vaginal microbiome
Engineered phage endolysin eliminates <i>Gardnerella</i> in bacterial vaginosis without damaging the healthy vaginal microbiome Open
Background Bacterial vaginosis is characterized by an imbalance of the vaginal microbiome in which the normally predominant lactobacilli are replaced by other bacterial species. Initiated by strains of the bacterium Gardnerella , a charact…
View article: Breaking the Vicious Cycle of Antibiotic Killing and Regrowth of Biofilm-Residing <i>Pseudomonas aeruginosa</i>
Breaking the Vicious Cycle of Antibiotic Killing and Regrowth of Biofilm-Residing <i>Pseudomonas aeruginosa</i> Open
Biofilm-residing bacteria embedded in an extracellular matrix are protected from diverse physicochemical insults. In addition to the general recalcitrance of biofilm bacteria, high bacterial loads in biofilm-associated infections significa…
View article: Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms
Inoculation density and nutrient level determine the formation of mushroom-shaped structures in Pseudomonas aeruginosa biofilms Open
Pseudomonas aeruginosa often colonises immunocompromised patients and the lungs of cystic fibrosis patients. It exhibits resistance to many antibiotics by forming biofilms, which makes it hard to eliminate. P . aeruginosa biofilms form mus…