Timo Strünker
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View article: Membrane potential and feedback dynamics regulate CatSper-mediated progesterone signaling in human sperm
Membrane potential and feedback dynamics regulate CatSper-mediated progesterone signaling in human sperm Open
Activation of the sperm-specific Ca 2+ channel CatSper by progesterone evokes rapid changes in intracellular Ca 2+ in human sperm that are required for fertilization. However, the mechanisms regulating the progesterone-induced Ca 2+ signal…
View article: The major phytocannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), affect the function of CatSper calcium channels in human sperm
The major phytocannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), affect the function of CatSper calcium channels in human sperm Open
STUDY QUESTION Do the main psychoactive phytocannabinoid delta-9-tetrahydrocannabinol (THC) and its non-psychoactive analog cannabidiol (CBD) affect human sperm function? SUMMARY ANSWER THC and CBD affect the sperm-specific Ca2+ channel Ca…
View article: Chemosensory signalling in human sperm is controlled by Ca<sup>2+</sup> influx via CatSper and Ca<sup>2+</sup> clearance via plasma membrane Ca<sup>2+</sup> ATPases
Chemosensory signalling in human sperm is controlled by Ca<sup>2+</sup> influx via CatSper and Ca<sup>2+</sup> clearance via plasma membrane Ca<sup>2+</sup> ATPases Open
Background and Purpose Loss of function of the sperm‐specific Ca 2+ channel CatSper is a common channelopathy that causes male infertility. CatSper controls the intracellular Ca 2+ concentration and, thereby, the motility of human sperm. A…
View article: ABHD2 activity is not required for the non-genomic action of progesterone on human sperm
ABHD2 activity is not required for the non-genomic action of progesterone on human sperm Open
Sperm activation is controlled by an influx of calcium ions through the CatSper channel, which is activated in the oviduct by a non-genomic action of progesterone. Progesterone has been hypothesized to act as an activator of ABHD2 activity…
View article: Publication Counts in Context: Normalization Using Query and Reference Terms in PubMed
Publication Counts in Context: Normalization Using Query and Reference Terms in PubMed Open
This article discusses the extensive use of publication counts as indicators of trends in the scientific activities of individual researchers, research groups, and entire disciplines. However, with the growing number of articles in general…
View article: The sperm-specific K+ channel Slo3 is inhibited by albumin and steroids contained in reproductive fluids
The sperm-specific K+ channel Slo3 is inhibited by albumin and steroids contained in reproductive fluids Open
To locate and fertilize the egg, sperm probe the varying microenvironment prevailing at different stages during their journey across the female genital tract. To this end, they are equipped with a unique repertoire of mostly sperm-specific…
View article: Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation
Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation Open
The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of …
View article: Author Response: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Author Response: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Full text Figures and data Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Methods Data availability References Peer review Author response Article and author information Metrics Abstract Cylicins are te…
View article: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 ( Cylc1/CYLC1 ) and the autosomal Cylicin 2 ( Cylc2/CYLC2 ) genes, have been i…
View article: Reviewer #2 (Public Review): Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Reviewer #2 (Public Review): Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes have been identi…
View article: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes have been identi…
View article: Reviewer #3 (Public Review): Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Reviewer #3 (Public Review): Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes have been identi…
View article: Reviewer #1 (Public Review): Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Reviewer #1 (Public Review): Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes have been identi…
View article: Author Response: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Author Response: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes have been identi…
View article: Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives
Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives Open
N -Methyl- D -aspartate receptors (NMDARs) composed of different splice variants display distinct pH sensitivities and are crucial for learning and memory, as well as for inflammatory or injury processes. Dysregulation of the NMDAR has bee…
View article: CCDC 2181677: Experimental Crystal Structure Determination
CCDC 2181677: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: O-017 A novel diagnostic test identifies patients suffering from loss of CatSper function
O-017 A novel diagnostic test identifies patients suffering from loss of CatSper function Open
Study question Is a loss of CatSper function in sperm a common cause of unexplained male infertility? Summary answer Loss of CatSper function leads to similar infertility phenotypes in mice and men and represents one of the most common cau…
View article: Unexplained infertility is frequently caused by defective CatSper function preventing sperm from penetrating the egg coat
Unexplained infertility is frequently caused by defective CatSper function preventing sperm from penetrating the egg coat Open
The infertility of many couples seems to rest on an enigmatic dysfunction of the men’s sperm, rendering early diagnosis and evidence-based treatment by medically assisted reproduction impossible. Using a novel laboratory test, we assessed …
View article: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis specific proteins which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 (Cylc1/CYLC1) and the autosomal Cylicin 2 (Cylc2/CYLC2) genes have been identif…
View article: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 ( Cylc1/CYLC1 ) and the autosomal Cylicin 2 ( Cylc2/CYLC2 ) genes, have been i…
View article: Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility
Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility Open
Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder affecting the function of motile cilia in several organ systems. In PCD, male infertility is caused by defective sperm flagella composition or deficient motile cilia function in t…
View article: Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human
Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human Open
Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin 1 ( Cylc1/CYLC1 ) and the autosomal Cylicin 2 ( Cylc2/CYLC2) genes have been ide…
View article: Synthesis and Functional Characterization of Novel RU1968-Derived CatSper Inhibitors with Reduced Stereochemical Complexity
Synthesis and Functional Characterization of Novel RU1968-Derived CatSper Inhibitors with Reduced Stereochemical Complexity Open
The sperm-specific Ca2+ channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration and, thereby, the swimming behavior of sperm from many species. The steroidal ethylenediamine RU1968 (1) represents a well-char…
View article: Downstream allosteric modulation of NMDA receptors by 3-benzazepine derivatives
Downstream allosteric modulation of NMDA receptors by 3-benzazepine derivatives Open
N-methyl-D-aspartate receptors (NMDARs) composed of different splice variants display distinct pH sensitivities and are crucial for learning and memory, as well as for inflammatory or injury processes. Dysregulation of the NMDAR is associa…
View article: Author response: Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes
Author response: Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Fluorescent probes tha…
View article: The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm Open
STUDY QUESTION Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? SUMMARY ANSWER The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affect…
View article: The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm
The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm Open
The sperm-specific Ca 2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E 1 that activate CatSper without involving classical nuclear and G protein-co…
View article: External fertilization is orchestrated by a pH-regulated soluble adenylyl cyclase controlling sperm motility and chemotaxis
External fertilization is orchestrated by a pH-regulated soluble adenylyl cyclase controlling sperm motility and chemotaxis Open
The reaction of CO 2 with H 2 O to form HCO 3 - and H + is one of the most important chemical equilibria in cells. In mammalian sperm, a soluble adenylyl cyclase (sAC) serves as cellular HCO 3 - sensor that conveys the equilibrium state vi…
View article: Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system
Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system Open
Motile cilia line the efferent ducts of the mammalian male reproductive tract. Several recent mouse studies have demonstrated that a reduced generation of multiple motile cilia in efferent ducts is associated with obstructive oligozoosperm…