Timo Ullrich
YOU?
Author Swipe
View article: Tuning of G-CSFR signaling by de novo-designed agonists
Tuning of G-CSFR signaling by de novo-designed agonists Open
Enhancing cytokine-based therapies by systematically tuning how an agonist associates its receptor is emerging as a powerful new concept in drug discovery. Here, we report the design and characterization of agonists that tune granulocyte-c…
View article: A strategy to design protein-based antagonists against type I cytokine receptors
A strategy to design protein-based antagonists against type I cytokine receptors Open
Excessive cytokine signaling resulting from dysregulation of a cytokine or its receptor can be a main driver of cancer, autoimmune, or hematopoietic disorders. Here, we leverage protein design to create tailored cytokine receptor blockers …
View article: Modulating G-CSFR Signaling Using <i>De Novo</i> Designed Cytokines
Modulating G-CSFR Signaling Using <i>De Novo</i> Designed Cytokines Open
Tightly modulating cytokine receptors, which naturally decode complex patterns of downstream signaling, is key to treating a wide range of diseases. De novo protein design is a powerful approach for creating ligands that can modulate the r…
View article: Tuning of granulopoietic signaling by<i>de novo</i>designed agonists
Tuning of granulopoietic signaling by<i>de novo</i>designed agonists Open
Enhancing cytokine-based therapies by systematically tuning how an agonist associates its receptor is emerging as a powerful new concept in drug discovery. Here, we report the design and characterization of agonists that tune the granulocy…
View article: Model‐based robustness and bistability analysis for methylation‐based, epigenetic memory systems
Model‐based robustness and bistability analysis for methylation‐based, epigenetic memory systems Open
In recent years, epigenetic memory systems have been developed based on DNA methylation and positive feedback systems. Achieving a robust design for these systems is generally a challenging and multifactorial task. We developed and validat…
View article: Development of an epigenetic tetracycline sensor system based on DNA methylation
Development of an epigenetic tetracycline sensor system based on DNA methylation Open
Bacterial live cell sensors are potentially powerful tools for the detection of environmental toxins. In this work, we have established and validated a flow cytometry readout for an existing bacterial arabinose sensor system with DNA methy…