Timon Beck
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View article: Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions
Cells dynamically adapt their nuclear volumes and proliferation rates during single to multicellular transitions Open
Tumour development and progression are associated with biophysical alterations that manifest across multiple spatial scales, from the subcellular to multicellular tissue scale. While cells dynamically regulate their biophysical properties …
View article: Optical characterization of molecular interaction strength in protein condensates
Optical characterization of molecular interaction strength in protein condensates Open
Biomolecular condensates have been identified as a ubiquitous means of intracellular organization, exhibiting very diverse material properties. However, techniques to characterize these material properties and their underlying molecular in…
View article: Optical characterization of molecular interaction strength in protein condensates
Optical characterization of molecular interaction strength in protein condensates Open
Biomolecular condensates have been identified as a ubiquitous means of intracellular organization, exhibiting very diverse material properties. However, techniques to characterize these material properties and their underlying molecular in…
View article: Estimation of the mass density of biological matter from refractive index measurements
Estimation of the mass density of biological matter from refractive index measurements Open
The quantification of physical properties of biological matter gives rise to novel ways of understanding functional mechanisms by utilizing models that explicitly depend on physical observables. One of the basic biophysical properties is t…
View article: Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment Open
Extracellular matrix (ECM) deposition after central nervous system (CNS) injury leads to inhibitory scarring in mammals, whereas it facilitates axon regeneration in the zebrafish. However, the molecular basis of these different fates is no…
View article: <i>In vivo</i> assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy
<i>In vivo</i> assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy Open
In processes such as development and regeneration, where large cellular and tissue rearrangements occur, cell fate and behaviour are strongly influenced by tissue mechanics. While most well-established tools probing mechanical properties r…
View article: <i>In vivo</i>assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy
<i>In vivo</i>assessment of mechanical properties during axolotl development and regeneration using confocal Brillouin microscopy Open
In processes such as development and regeneration, where large cellular and tissue rearrangements occur, cell fate and behavior are strongly influenced by tissue mechanics. While most well-established tools probing mechanical properties re…
View article: Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity
Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity Open
Quantitative measurements of physical parameters become increasingly important for understanding biological processes. Brillouin microscopy (BM) has recently emerged as one technique providing the 3D distribution of viscoelastic properties…
View article: PNIPAAm microgels with defined network architecture as temperature sensors in optical stretchers
PNIPAAm microgels with defined network architecture as temperature sensors in optical stretchers Open
Stretching living cells with light is a key method to assess their mechanics. To estimate the heat, cells experience during this procedure, microgels are utilized to relate temperature changes – caused by optical stretchers – to hydrogel s…
View article: Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy
Mapping Tumor Spheroid Mechanics in Dependence of 3D Microenvironment Stiffness and Degradability by Brillouin Microscopy Open
Altered biophysical properties of cancer cells and of their microenvironment contribute to cancer progression. While the relationship between microenvironmental stiffness and cancer cell mechanical properties and responses has been previou…
View article: Mapping tumor spheroid mechanics in dependence of 3D microenvironment stiffness and degradability by Brillouin microscopy
Mapping tumor spheroid mechanics in dependence of 3D microenvironment stiffness and degradability by Brillouin microscopy Open
Altered biophysical properties of cancer cells and of their microenvironment contribute to cancer progression. While the relationship between microenvironmental stiffness and cancer cell mechanical properties and responses has been previou…
View article: Author response: Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity
Author response: Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Quantitative measureme…
View article: Optical quantification of intracellular mass density and cell mechanics in 3D mechanical confinement
Optical quantification of intracellular mass density and cell mechanics in 3D mechanical confinement Open
Optical quantification of intracellular mass density using optical diffraction tomography (ODT) and cell mechanics using Brillouin spectroscopy under 3D mechanical confinement.
View article: Correlative all-optical quantification of mass density and mechanics of sub-cellular compartments with fluorescence specificity
Correlative all-optical quantification of mass density and mechanics of sub-cellular compartments with fluorescence specificity Open
Quantitative measurements of physical parameters become increasingly important for understanding biological processes. Brillouin microscopy (BM) has recently emerged as one technique providing the 3D distribution of viscoelastic properties…
View article: Recent progress and current opinions in Brillouin microscopy for life science applications
Recent progress and current opinions in Brillouin microscopy for life science applications Open
Many important biological functions and processes are reflected in cell and tissue mechanical properties such as elasticity and viscosity. However, current techniques used for measuring these properties have major limitations, such as that…