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View article: Effective deep brain stimulation for obsessive-compulsive disorder and Tourette Syndrome increases network-wide neural variability
Effective deep brain stimulation for obsessive-compulsive disorder and Tourette Syndrome increases network-wide neural variability Open
Introduction Deep brain stimulation (DBS) is an effective therapy for obsessive-compulsive disorder (OCD) and Tourette syndrome. Our previous results demonstrated disrupted circadian periodicity and increased neural variability in the regi…
View article: Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants Open
Brain-computer interface research can inspire closed-loop neuromodulation therapies, promising spatiotemporal precision for the treatment of brain disorders. Decoding dynamic patient states from brain signals with machine learning is requi…
View article: Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease
Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease Open
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson’s disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic sti…
View article: Movement execution defines a distinct neural state in dyskinesia and enhances decoding
Movement execution defines a distinct neural state in dyskinesia and enhances decoding Open
Parkinson patients suffer from levodopa-induced dyskinesia, which occur adversely to chronic dopaminergic treatment. These abnormal involuntary movements can only partly be actively suppressed and affect quality of life. A lowered motor in…
View article: Deep neurobehavioral phenotyping uncovers neural fingerprints of locomotor deficits in Parkinson’s disease
Deep neurobehavioral phenotyping uncovers neural fingerprints of locomotor deficits in Parkinson’s disease Open
Gait deficits present an unresolved therapeutic challenge in Parkinson’s Disease. At the behavioral level, symptoms exhibit heterogeneity, including bradykinesia and hypokinesia during cyclical limb movement, as well as sudden interruption…
View article: Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson’s disease
Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson’s disease Open
Deep brain stimulation is a brain circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with brain disorders. In Parkinson’s disease, subthalamic deep brain stimulation cli…
View article: Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia
Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia Open
Objective Deep brain stimulation offers a unique opportunity to record neural activity of the basal ganglia. While much work in dystonia has focused on the globus pallidus internus, expanding research to investigate subthalamic nucleus (ST…
View article: Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease
Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease Open
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson’s disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic sti…
View article: Reinforcement of movement speed through speed-selective deep brain stimulation in Parkinson’s disease
Reinforcement of movement speed through speed-selective deep brain stimulation in Parkinson’s disease Open
View article: Author response: Cortical beta oscillations map to shared brain networks modulated by dopamine
Author response: Cortical beta oscillations map to shared brain networks modulated by dopamine Open
View article: Cortical beta oscillations map to shared brain networks modulated by dopamine
Cortical beta oscillations map to shared brain networks modulated by dopamine Open
Brain rhythms can facilitate neural communication for the maintenance of brain function. Beta rhythms (13–35 Hz) have been proposed to serve multiple domains of human ability, including motor control, cognition, memory, and emotion, but th…
View article: Cortical beta oscillations map to shared brain networks modulated by dopamine
Cortical beta oscillations map to shared brain networks modulated by dopamine Open
Brain rhythms can facilitate neural communication for the maintenance of brain function. Beta rhythms (13–35 Hz) have been proposed to serve multiple domains of human ability, including motor control, cognition, memory and emotion, but the…
View article: Author response: Cortical beta oscillations map to shared brain networks modulated by dopamine
Author response: Cortical beta oscillations map to shared brain networks modulated by dopamine Open
View article: Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease
Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease Open
The ability to initiate volitional action is fundamental to human behaviour. Loss of dopaminergic neurons in Parkinson's disease is associated with impaired action initiation, also termed akinesia. Both dopamine and subthalamic deep brain …
View article: Cortical beta oscillations map to shared brain networks modulated by dopamine
Cortical beta oscillations map to shared brain networks modulated by dopamine Open
Brain rhythms can facilitate neural communication for the maintenance of brain function. Beta rhythms (13–35 Hz) have been proposed to serve multiple domains of human ability, including motor control, cognition, memory and emotion, but the…
View article: Cortical beta oscillations map to shared brain networks modulated by dopamine
Cortical beta oscillations map to shared brain networks modulated by dopamine Open
Brain rhythms can facilitate neural communication for the maintenance of brain function. Beta rhythms (13–35 Hz) have been proposed to serve multiple domains of human ability, including motor control, cognition, memory, and emotion, but th…
View article: Generalized sleep decoding with basal ganglia signals in multiple movement disorders
Generalized sleep decoding with basal ganglia signals in multiple movement disorders Open
Sleep disturbances profoundly affect the quality of life in individuals with neurological disorders. Closed-loop deep brain stimulation (DBS) holds promise for alleviating sleep symptoms, however, this technique necessitates automated slee…
View article: Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease
Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease Open
Deep brain stimulation is a brain circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with brain disorders. In Parkinson's disease, subthalamic deep brain stimulation cli…
View article: Cortical beta oscillations map to shared brain networks modulated by dopamine
Cortical beta oscillations map to shared brain networks modulated by dopamine Open
Brain rhythms can facilitate neural communication for the maintenance of brain function. Beta rhythms (13–35 Hz) have been proposed to serve multiple domains of human ability, including motor control, cognition, memory and ewmotion, but th…
View article: Single threshold adaptive deep brain stimulation in Parkinson's disease depends on parameter selection, movement state and controllability of subthalamic beta activity
Single threshold adaptive deep brain stimulation in Parkinson's disease depends on parameter selection, movement state and controllability of subthalamic beta activity Open
Our results highlight the interaction between single threshold aDBS parameter selection, movement state and controllability in driving subthalamic beta activity and motor performance. By this means, we identify directions for the further d…
View article: Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease
Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease Open
The ability to initiate volitional action is fundamental to human behaviour. Loss of dopaminergic neurons in Parkinson’s disease is associated with impaired action initiation, also termed akinesia. Both dopamine and subthalamic deep brain …
View article: Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants Open
View article: Pallidal activities during sleep and sleep decoding in dystonia, Huntington's, and Parkinson's disease
Pallidal activities during sleep and sleep decoding in dystonia, Huntington's, and Parkinson's disease Open
Our findings revealed strong sleep-stage dependent distinctions in pallidal oscillations in multiple movement disorders. Pallidal oscillatory features were sufficient for sleep stage decoding. These data may facilitate the development of a…
View article: Parameter selection drives electrophysiological responses to adaptive deep brain stimulation in Parkinson’s disease
Parameter selection drives electrophysiological responses to adaptive deep brain stimulation in Parkinson’s disease Open
Introduction: Adaptive deep brain stimulation (DBS) aims at improving DBS therapy by adjusting stimulation amplitude in response to biomarkers tracked in real-time. In Parkinson's Disease (PD), one type of aDBS exploits fast fluctuations o…
View article: Single Threshold Adaptive Deep Brain Stimulation in Parkinson's Disease Depends on Parameter Selection, Movement State and Controllability of Subthalamic Beta Activity
Single Threshold Adaptive Deep Brain Stimulation in Parkinson's Disease Depends on Parameter Selection, Movement State and Controllability of Subthalamic Beta Activity Open
View article: Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease
Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease Open
Brain signal decoding promises significant advances in the development of clinical brain computer interfaces (BCI). In Parkinson’s disease (PD), first bidirectional BCI implants for adaptive deep brain stimulation (DBS) are now available. …
View article: Author response: Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease
Author response: Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Brain signal decoding …
View article: Replication Data for: Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease
Replication Data for: Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease Open
This dataset contains the data required for replication of the results published in the paper titled "Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease". The abstract for th…
View article: Deep Learning-Based Indoor Localization Using Multi-View BLE Signal
Deep Learning-Based Indoor Localization Using Multi-View BLE Signal Open
In this paper, we present a novel Deep Neural Network-based indoor localization method that estimates the position of a Bluetooth Low Energy (BLE) transmitter (tag) by using the received signals’ characteristics at multiple Anchor Points (…
View article: BLE Ray-Tracing Simulation Dataset
BLE Ray-Tracing Simulation Dataset Open
BLE ray-tracing propagation data generated via Altair Feko WinProp software. The core simulation environment is a room with dimensions 14m x 7m including several furniture configurations. Four horizontal facing APs are placed in the corner…