Timothy A. Bird
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View article: Pellino 1 Is Required for Interleukin-1 (IL-1)-mediated Signaling through Its Interaction with the IL-1 Receptor-associated Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex
Pellino 1 Is Required for Interleukin-1 (IL-1)-mediated Signaling through Its Interaction with the IL-1 Receptor-associated Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex Open
The signaling pathway downstream of the mammalian interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) is evolutionally conserved with that mediated by the Drosophila Toll protein. Toll initiates its signal through the adapter molecule …
View article: Purification, Cloning, and Characterization of Nek8, a Novel NIMA-related Kinase, and Its Candidate Substrate Bicd2
Purification, Cloning, and Characterization of Nek8, a Novel NIMA-related Kinase, and Its Candidate Substrate Bicd2 Open
We describe the isolation, cloning, and characterization of human Nek8, a new mammalian NIMA-related kinase, and its candidate substrate Bicd2. Nek8 was isolated as a beta-casein kinase activity in rabbit lung and has an N-terminal catalyt…
View article: Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling
Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling Open
We have identified a novel member of the interleukin-1 (IL-1) receptor family, which we have termed AcPL. In transient transfection assays, we were unable to demonstrate a role for AcPL in IL-1-induced activation of NFkappaB. Interleukin-1…
View article: Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit
Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit Open
In fibroblasts and hepatoma cells, interleukin-1 (IL-1) treatment results in the rapid nuclear accumulation of the transcription factor NF-kappaB, present largely as p65 (RelA)/p50 heterodimers. It is well established that this process is …
View article: Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.
Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase. Open
In KB epidermoid cells, we previously showed that interleukin-1 alpha (IL-1) and various mitogens activate the mitogen-activated protein (MAP) kinases ERK1 and ERK2, which phosphorylate both myelin basic protein (MBP) and a peptide contain…
View article: Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes.
Oncostatin M and leukemia inhibitory factor trigger overlapping and different signals through partially shared receptor complexes. Open
Leukemia inhibitory factor (LIF) and oncostatin M (OSM) both bind to the same receptor with high affinity and thus mediate an overlapping spectrum of biological activities, the signal transduction mechanisms for which are unclear. We show …
View article: Interleukin 1 signaling occurs exclusively via the type I receptor.
Interleukin 1 signaling occurs exclusively via the type I receptor. Open
Two receptors for the proinflammatory cytokine interleukin 1 (IL-1) have been cloned and characterized biochemically. While it has been well established that the type I (80-kDa) IL-1 receptor can mediate responses to IL-1, the function of …
View article: Distinct Regions of the Human Granulocyte-Colony-Stimulating Factor Receptor Cytoplasmic Domain Are Required for Proliferation and Gene Induction
Distinct Regions of the Human Granulocyte-Colony-Stimulating Factor Receptor Cytoplasmic Domain Are Required for Proliferation and Gene Induction Open
Using two different cell systems, we show that the cytoplasmic domain of the granulocyte-colony-stimulating factor receptor (G-CSFR) may be composed of at least two functional regions. The first, within the membrane-proximal 57 amino acids…
View article: Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases. Open
In this study we describe the activation of a protein kinase which phosphorylates a peptide, T669, comprising amino acids 663-681 of the epidermal growth factor receptor and containing the phosphate acceptor site Pro-Leu-Thr669-Pro. In the…
View article: Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters.
Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters. Open
Exposure of quiescent cultures of human gingival fibroblasts (HuGi) and porcine synovicocytes (PSF) to human recombinant interleukin 1 alpha or -beta (IL1 alpha and -beta) enhanced the rate of glycolysis as judged by increased lactate prod…
View article: Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). Open
The post-receptor events which follow the binding of interleukin 1 (IL1) to cells are unclear. The present studies provide evidence for the activation of a guanine nucleotide binding protein (G protein) by IL1 in the membranes of an IL1 re…
View article: Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654.
Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. Open
Interleukin 1 or tumor necrosis factor alpha can cause a transient down-modulation of epidermal growth factor (EGF) binding to quiescent fibroblast monolayers; the effect results from a reduction in EGF receptor (EGF-R) affinity and appear…
View article: IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism.
IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism. Open
The effect of the human rIL-1 alpha and rTNF-alpha on the binding of 125I-labeled epidermal growth factor ([125I]EGF) to its receptor (EGF-R) has been studied in human gingival fibroblasts (HuGi). Incubation of these cells with recombinant…
View article: Murine interleukin 1 receptor. Direct identification by ligand blotting and purification to homogeneity of an interleukin 1-binding glycoprotein.
Murine interleukin 1 receptor. Direct identification by ligand blotting and purification to homogeneity of an interleukin 1-binding glycoprotein. Open
Functional receptors (IL1-R) for the proinflammatory cytokine interleukin 1 (IL1) were solubilized from plasma membranes of the NOB-1 subclone of murine EL4 6.1 thymoma cells using the zwitterionic detergent 3[(3-cholamidopropyl)dimethylam…
View article: Murine interleukin‐1 receptor: Differences in binding properties between fibroblastic and thymoma cells and evidence for a two‐chain receptor model
Murine interleukin‐1 receptor: Differences in binding properties between fibroblastic and thymoma cells and evidence for a two‐chain receptor model Open
The concentration of porcine interleukin‐1β (pIL1β) required to elicit half‐maximal IL2 production from NOB‐1, a subline of murine thymoma EL4, was 100‐fold greater than for p1Lα. In contrast, similar doses of each type of IL1 stimulated i…
View article: Mechanism for the decreased biosynthesis of cartilage proteoglycan in the scorbutic guinea pig.
Mechanism for the decreased biosynthesis of cartilage proteoglycan in the scorbutic guinea pig. Open
Our previous work showed that vitamin C deficiency caused about a 70-80% decrease in the incorporation of [35S]sulfate into proteoglycan of guinea pig costal cartilage, coordinately with a decrease in collagen synthesis (Bird, T. A., Spanh…
View article: The inhibition of lysyl oxidase <i>in vivo</i> by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo
The inhibition of lysyl oxidase <i>in vivo</i> by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo Open
Isonicotinic acid hydrazide (isoniazid) causes a large increase in the salt-solubility of collagen when injected into chick embryos; this change is accompanied by the inactivation of lysyl oxidase (EC 1.4.3.13), the enzyme responsible for …
View article: The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo
The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo Open
The vitamin B-6 antimetabolite 4-deoxypyridoxine, when injected into 13-day chick embryos, has the effect of increasing the amount of collagen solubilized from the leg bones by buffered saline solutions, 24 h after the injection. This effe…