Timothy C. Wang
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View article: Proteomic and metabolomic profiling of plasma reveals physiologic changes in patients with convalescent COVID-19
Proteomic and metabolomic profiling of plasma reveals physiologic changes in patients with convalescent COVID-19 Open
This study revealed differential metabolite and protein compositions in the plasma of patients with convalescent COVID-19 compared with uninfected controls. The main physiological changes were associated with the pathology of this disease,…
View article: Colibactin-producing <i>E. coli</i> promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation
Colibactin-producing <i>E. coli</i> promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation Open
Background & Aims Gastroesophageal adenocarcinoma (GEAC) is a malignancy of the gastroesophageal junction (GEJ) and is associated with reflux of gastroduodenal contents and Barrett’s Esophagus (BE). A shift towards gram-negative bacteria i…
View article: Development of an inspection scheme for verifying product reliability in the modern manufacturing industry
Development of an inspection scheme for verifying product reliability in the modern manufacturing industry Open
Modern products are typically offered with a warranty, ensuring consumer protection through free repairs or replacements in the event of failure within the warranty period. Consequently, the length of the warranty period has become a cruci…
View article: Posterior ulnar recurrent artery perforator flap for elbow reconstruction: a forearm-based propeller flap
Posterior ulnar recurrent artery perforator flap for elbow reconstruction: a forearm-based propeller flap Open
Soft tissue reconstruction around the elbow is challenging due to the need for durable yet pliable coverage that preserves joint mobility and function. We present the case of a 56-year-old gentleman with a chronic elbow wound secondary to …
View article: Entangled cellular and molecular relationships at the sensory neuron-cancer interface
Entangled cellular and molecular relationships at the sensory neuron-cancer interface Open
View article: Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett’s esophagus
Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett’s esophagus Open
Bile acids are a major component of gastro-esophageal refluxate, thought to contribute to the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). As the microbiome shifts with EAC progression and bile acids influen…
View article: Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1
Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1 Open
Nerves have been shown to regulate cancer progression. However, a clear demonstration of a role for axon guidance molecules in pancreatic tumorigenesis, innervation, and metastasis has been lacking. Using murine Kras G12D -mutant pancreati…
View article: ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment
ARID1A mutation drives gastric tumorigenesis via activating type 2 immune dominant microenvironment Open
View article: A scalable, all-optical method for mapping synaptic connectivity with cell-type specificity
A scalable, all-optical method for mapping synaptic connectivity with cell-type specificity Open
Single-cell transcriptomics has uncovered the enormous heterogeneity of cell types that compose each region of the mammalian brain, but describing how such diverse types connect to form functional circuits has remained challenging. Current…
View article: A phase 0, window of opportunity study of parasympathetic stimulation with bethanechol in localized pancreatic adenocarcinoma prior to surgery
A phase 0, window of opportunity study of parasympathetic stimulation with bethanechol in localized pancreatic adenocarcinoma prior to surgery Open
Background The parasympathetic branch of the autonomic nervous system has shown tumor-suppressive effects in preclinical models of pancreatic adenocarcinoma (PDAC) by inhibiting cancer stem cells and suppressing inflammatory cytokine produ…
View article: Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer
Knowledge Discovery in Databases of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer Open
Background: Knowledge discovery in databases (KDD) can contribute to translational research, also known as translational medicine, by bridging the gap between in vitro and in vivo studies, and clinical applications. Here, we propose a ‘sys…
View article: Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression
Regulatory network analysis of Dclk1 gene expression reveals a tuft cell-ILC2 axis that inhibits pancreatic tumor progression Open
Doublecortin-like kinase 1 (Dclk1) expression identifies cells that are rare in normal pancreas but occur with an increased frequency in pancreatic neoplasia. The identity of these cells has been a matter of debate. We employed Dclk1 repor…
View article: Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy
Tumor microenvironment and immune-related myositis: addressing muscle wasting in cancer immunotherapy Open
Cancer immunotherapy, which leverages the immune system to target neoplastic cells, has undergone significant transformation in recent. However, immunotherapy may have negative effects on skeletal muscle function, causing muscle wasting an…
View article: Proximal Olecranon Free Flap for Cystic Scaphoid Nonunion: An Anatomical Feasibility Study
Proximal Olecranon Free Flap for Cystic Scaphoid Nonunion: An Anatomical Feasibility Study Open
Background: The treatment of scaphoid nonunion is challenging, with one approach aiming to provide vascularized bone to encourage union. While the iliac crest and medial femoral condyle are well-described donor sites for osseous flaps, the…
View article: <i>Muc6</i> -expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions
<i>Muc6</i> -expressing gastric isthmus progenitors contribute to regeneration and metaplasia supported by myeloid-mesenchymal interactions Open
Summary Gastric mucosal homeostasis is maintained by tissue-resident stem and progenitor cells residing in the isthmus region. Following mucosal injury, surviving cells contribute to regeneration, coinciding with characteristic pathologica…
View article: Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury
Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury Open
Background & Aims Epithelial muscarinic acetylcholine receptor subtype 3 (M3R) signaling modulates intestinal stem and progenitor cell function, yet its impact on colonic homeostasis remains unclear. Hence, this study explores the sex-spec…
View article: Figure S6 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
Figure S6 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor Open
PKA inhibition (PKAi) reduces the growth of primary human SCLC cells
View article: Figure S4 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
Figure S4 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor Open
ADRB2 regulates the growth of human SCLC cells
View article: Figure S2 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
Figure S2 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor Open
Co-culture with stellate ganglia (SG) promotes the growth of mouse SCLC
View article: Figure S1 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
Figure S1 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor Open
Sympathetic and parasympathetic nerve fibers in mouse SCLC
View article: Figure S3 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
Figure S3 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor Open
High levels of ADRB2 promote the growth of mouse SCLC
View article: Figure S5 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
Figure S5 from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor Open
ICI treatment reduces the growth of SCLC
View article: Data from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor
Data from Sympathetic Neurons Promote Small Cell Lung Cancer through the β2-Adrenergic Receptor Open
The vagal nerve is linked to tumorigenesis in multiple tissues, including small cell lung cancer (SCLC). However, the role of sympathetic neurons in SCLC development remains unknown. In this study, we observed a significant reduction in tu…
View article: Evaluation of suitable reference genes for gene expression studies in the developing mouse cortex using RT-qPCR
Evaluation of suitable reference genes for gene expression studies in the developing mouse cortex using RT-qPCR Open
This study identifies B2m, Gapdh, and Hprt as suitable reference genes for relative quantification in RT-qPCR-based cortical development studies spanning the period of embryonic day 15 to postnatal day 0.
View article: Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with a five-year survival rate of 10–15% due to late-stage diagnosis and limited efficacy of existing treatments. This study utilized proteomics-based sys…
View article: Peripheral blood immunoinflammatory biomarkers: prospective predictors of postoperative long-term survival and chronic postsurgical pain in breast cancer
Peripheral blood immunoinflammatory biomarkers: prospective predictors of postoperative long-term survival and chronic postsurgical pain in breast cancer Open
Background Tumor progression and chronic postsurgical pain (CPSP) in patients with breast cancer are both significantly influenced by inflammation. The associations between immunoinflammatory biomarkers and long-term survival, as well as C…
View article: Data from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Data from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression Open
Cancer-associated fibroblasts (CAF) and nerves, components of the tumor microenvironment, have each been shown to directly promote gastrointestinal cancers. However, it remains unknown whether these cells interact with each other to regula…
View article: Supplementary Tables S1 and S2 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Supplementary Tables S1 and S2 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression Open
Supplementary Table S1: List of differentially expressed genes in RNA-seq from norepinephrine- or vehicle-treated AKP tumor organoids. Supplementary Table S2: Gene set enrichment analyses using RNA-seq data from norepinephrine- or vehicle-…
View article: Supplementary Figures S1-10 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Supplementary Figures S1-10 from Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression Open
Supplementary Figure S1 supports Figure 1 and shows stromal NGF expression and innervation in human colorectal cancer tissues. Supplementary Figure S2 supports Figure 1 and shows stromal NGF expression and innervation in mouse colorectal c…
View article: Predicting financial distress as repeated events: Evidence from China
Predicting financial distress as repeated events: Evidence from China Open