Timothy C.H. Low
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View article: The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding “ZZ” domain
The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding “ZZ” domain Open
Posttranscriptional regulation is particularly prominent during the maternal-to-zygotic transition (MZT), a developmental phase during which a large proportion of maternally provided mRNAs is repressed and cleared from metazoan embryos. RN…
View article: The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization
The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization Open
ORB2 is the Drosophila ortholog of the human CPEB2-4 family of RNA-binding proteins, which include a conserved C-terminal Zinc-binding (‘ZZ’) domain. We have recently shown that this domain interacts with several translational co-repressor…
View article: The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization
The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization Open
ORB2 is the Drosophila ortholog of the human CPEB2-4 family of RNA-binding proteins, which include a conserved C-terminal Zinc-binding (‘ZZ’) domain. We have recently shown that this domain interacts with several translation co-repressors …
View article: The CPEB ortholog Orb2 regulates brain size through the TRIM-NHL RNA-binding protein, Brain tumor
The CPEB ortholog Orb2 regulates brain size through the TRIM-NHL RNA-binding protein, Brain tumor Open
Neurodevelopment requires precise translational control, the disruption of which is implicated in various neurological disorders, including developmental delays, intellectual disability, and microcephaly. We report a novel role for the Dro…
View article: The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding ‘ZZ’ domain
The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding ‘ZZ’ domain Open
Post-transcriptional regulation is particularly prominent during the maternal-to-zygotic transition (MZT), a developmental phase during which a large proportion of maternally provided mRNAs is repressed and cleared from metazoan embryos. R…
View article: Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos
Smaug regulates germ plasm assembly and primordial germ cell number in Drosophila embryos Open
During Drosophila oogenesis, the Oskar (OSK) RNA binding protein (RBP) determines the amount of germ plasm that assembles at the posterior pole of the oocyte. Here, we identify mechanisms that subsequently regulate germ plasm assembly in t…
View article: Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition
Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition Open
In animal embryos, the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents more than half of the protein-coding capacity of Drosophila melan…
View article: Precise temporal regulation of post-transcriptional repressors is required for an orderly<i>Drosophila</i>maternal-to-zygotic transition
Precise temporal regulation of post-transcriptional repressors is required for an orderly<i>Drosophila</i>maternal-to-zygotic transition Open
SUMMARY In animal embryos the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents over half of the protein coding capacity of the Drosophila…