Timothy Coker
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View article: The Clinical and Economic Burden of Chronic Kidney Disease in Poland: Inside Patient-Level Microsimulation Modelling of CKD
The Clinical and Economic Burden of Chronic Kidney Disease in Poland: Inside Patient-Level Microsimulation Modelling of CKD Open
Background/Objectives: Chronic kidney disease (CKD) is associated with increased annual costs, with the highest costs attributable to renal replacement therapy (RRT). These costs will rise as prevalence increases. Therefore, forecasting th…
View article: Estimating the prevalence of late-onset Fabry disease in the US in 2024
Estimating the prevalence of late-onset Fabry disease in the US in 2024 Open
Fabry disease is a rare lysosomal storage condition in which sphingolipid levels build up to harmful levels in various bodily organs, eventually leading to life-threatening complications such as stroke and kidney failure. Fabry disease is …
View article: Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories
Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories Open
This study highlights the disproportionate population-level clinical and economic burden associated with individuals within KDIGO uACR categories A1 and A2, who represent most of the CKD population. This awareness will help health care dec…
View article: WCN24-888 INSIDE CKD - MAKING CKD DIAGNOSIS MORE COSTEFFECTIVE AND EFFICIENT BY USING A DIGITAL SOLUTION: A MODELLING STUDY ACROSS SIX COUNTRIES
WCN24-888 INSIDE CKD - MAKING CKD DIAGNOSIS MORE COSTEFFECTIVE AND EFFICIENT BY USING A DIGITAL SOLUTION: A MODELLING STUDY ACROSS SIX COUNTRIES Open
Chronic Kidney Disease (CKD) affects around one in ten people around the world. However, many cases remain undiagnosed. Annual CKD screening is recommended in high-risk groups but is often underperformed due to limited access to screening …
View article: #4028 INSIDE CKD: PROJECTING THE POPULATION LEVEL CLINICAL BURDEN OF CHRONIC KIDNEY DISEASE ACCORDING TO URINE ALBUMIN-TO-CREATININE RATIO CATEGORIES
#4028 INSIDE CKD: PROJECTING THE POPULATION LEVEL CLINICAL BURDEN OF CHRONIC KIDNEY DISEASE ACCORDING TO URINE ALBUMIN-TO-CREATININE RATIO CATEGORIES Open
Background and Aims Chronic kidney disease (CKD) and its associated complications constitute a major challenge for healthcare systems worldwide. Albuminuria, measured as albumin-to-creatinine ratio (uACR), is a critical marker of glomerula…
View article: How Could Different Obesity Scenarios Alter the Burden of Type 2 Diabetes and Liver Disease in Saudi Arabia?
How Could Different Obesity Scenarios Alter the Burden of Type 2 Diabetes and Liver Disease in Saudi Arabia? Open
Introduction: Obesity is a major risk factor for type 2 diabetes (T2DM) and liver disease, and obesity-attributable liver disease is a common indication for liver transplant. Obesity prevalence in Saudi Arabia (SA) has increased in recent …
View article: The future health and economic burden of obesity-attributable type 2 diabetes and liver disease among the working-age population in Saudi Arabia
The future health and economic burden of obesity-attributable type 2 diabetes and liver disease among the working-age population in Saudi Arabia Open
Background Obesity and type 2 diabetes (T2DM) are increasing in Saudi Arabia (SA). Among other conditions, these risk factors increase the likelihood of non-alcoholic fatty liver disease (NAFLD), which in turn increases risks for advanced …
View article: Evidence for the Widespread Occurrence of Bacteria Implicated in Acute Oak Decline from Incidental Genetic Sampling
Evidence for the Widespread Occurrence of Bacteria Implicated in Acute Oak Decline from Incidental Genetic Sampling Open
Acute Oak Decline (AOD) is complex syndrome affecting Britain’s keystone native oak species, (Quercus robur L. and Q. petraea L. (Matt.) Liebl.), in some cases causing mortality within five years of symptom development. The most distinguis…
View article: Evidence for the Widespread Occurrence of Bacteria Implicated in Acute Oak Decline from Incidental Genetic Sampling
Evidence for the Widespread Occurrence of Bacteria Implicated in Acute Oak Decline from Incidental Genetic Sampling Open
Acute Oak Decline (AOD) is complex syndrome affecting Britain’s keystone native oak species, (Quercus robur L. and Q. petraea L. (Matt.) Liebl.), in some cases causing mortality within five years of symptom development. The most dist…
View article: Genomic structure and diversity of oak populations in British parklands
Genomic structure and diversity of oak populations in British parklands Open
Societal Impact Statement The largest populations of veteran oak trees in Europe are found in British parklands: managed wood pastures up to 1000 years old. Here, we present genomic evidence that parkland oak populations harbour considerab…
View article: Genomic structure and diversity of oak populations in British Parklands
Genomic structure and diversity of oak populations in British Parklands Open
The two predominant oak species in Britain are Quercus robur (English or pedunculate oak) and Q. petraea (sessile oak). We sequenced the whole genomes of 386 oak trees from four British parkland sites and found over 50 million nuclear sing…
View article: Damage Repair versus Aging in an Individual-Based Model of Biofilms
Damage Repair versus Aging in an Individual-Based Model of Biofilms Open
Damage is an inevitable consequence of life. For unicellular organisms, this leads to a trade-off between allocating resources into damage repair or into growth coupled with segregation of damage upon cell division, i.e., aging and senesce…
View article: Damage Repair Versus Aging in Biofilms
Damage Repair Versus Aging in Biofilms Open
The extent of senescence due to damage accumulation (or aging) is evidently evolvable as it varies hugely between species and is not universal, suggesting that its fitness advantages depend on life history and environment. In contrast, rep…
View article: Damage repair versus aging in an individual-based model of biofilms supplementary file 2
Damage repair versus aging in an individual-based model of biofilms supplementary file 2 Open
Supplementary files relating to simulations that vary key growth parameters and searches of the genomes of microbial isolates for the presence of repair genes.
View article: Damage repair versus aging in an individual-based model of biofilms supplementary file 2
Damage repair versus aging in an individual-based model of biofilms supplementary file 2 Open
Supplementary files relating to simulations that vary key growth parameters and searches of the genomes of microbial isolates for the presence of repair genes.
View article: The viability of a breeding programme for ash in the British Isles in the face of ash dieback
The viability of a breeding programme for ash in the British Isles in the face of ash dieback Open
Societal Impact Statement The current ash dieback epidemic in Europe caused by Hymenoscyphus fraxineus poses a key question to policy makers: whether or not to commit time and resources to the initiation of a breeding programme for the dev…
View article: Estimating mortality rates of European ash (<i>Fraxinus excelsior</i>) under the ash dieback (<i>Hymenoscyphus fraxineus</i>) epidemic
Estimating mortality rates of European ash (<i>Fraxinus excelsior</i>) under the ash dieback (<i>Hymenoscyphus fraxineus</i>) epidemic Open
Societal Impact Statement Damage to ash trees by ash dieback caused by the emerging fungal pathogen Hymenoscyphus fraxineus is impacting people across Europe. This poses challenges to: public safety; productivity of commercial forestry; gr…
View article: Spatial dissection of the Arabidopsis thaliana transcriptional response to downy mildew using Fluorescence Activated Cell Sorting
Spatial dissection of the Arabidopsis thaliana transcriptional response to downy mildew using Fluorescence Activated Cell Sorting Open
Changes in gene expression form a crucial part of the plant response to infection. In the last decade, whole-leaf expression profiling has played a valuable role in identifying genes and processes that contribute to the interactions betwee…