Timothy E. Peterson
YOU?
Author Swipe
View article: NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx
NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx Open
Osteoclasts (OCs) differentiate from macrophages in response to RANKL. Here, we investigated the role of the NLRP3 inflammasome in mouse macrophages, with or without exposure to RANKL. Unexpectedly, we found that NLRP3 expression gradually…
View article: Living health-promotion campaigns for communities in the United States: Decentralized content extraction and sharing through AI
Living health-promotion campaigns for communities in the United States: Decentralized content extraction and sharing through AI Open
Even though health-promotion campaigns can elicit behavioral change among constituents, these initiatives are generally implemented through expensive, centralized, unsystematic, and time-consuming efforts led by creatives and officials in …
View article: DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8
DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8 Open
Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and restore immune homeostas…
View article: O-050 Human platelet-derived exosomes as bioactive material for aneurysm treatment with platinum coils:<i>in vitro</i>proof of concept study
O-050 Human platelet-derived exosomes as bioactive material for aneurysm treatment with platinum coils:<i>in vitro</i>proof of concept study Open
Introduction While endovascular coiling is a common method for treating intracranial aneurysms, recurrence and retreatment rates are high. Coating coils with biological agents has emerged as a promising strategy for improving aneurysm occl…
View article: Clinical efficacy of sequencing CD38 targeting monoclonal antibodies in relapsed refractory multiple myeloma: A multi‐institutional experience
Clinical efficacy of sequencing CD38 targeting monoclonal antibodies in relapsed refractory multiple myeloma: A multi‐institutional experience Open
To the Editor: Multiple Myeloma (MM) remains largely incurable with a small proportion of patients attaining long-term disease control. Monoclonal antibodies (MoAbs) targeting plasma cell surface antigens play an increasing role in improvi…
View article: STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma Open
Background H3K27M-mutant diffuse midline glioma (DMG) is a lethal brain tumor that usually occurs in children. Despite advances in our understanding of its underlying biology, efficacious therapies are severely lacking. Methods We screened…
View article: Phase I trial of adjuvant mature autologous dendritic cell/allogeneic tumor lysate vaccines in combination with temozolomide in newly diagnosed glioblastoma
Phase I trial of adjuvant mature autologous dendritic cell/allogeneic tumor lysate vaccines in combination with temozolomide in newly diagnosed glioblastoma Open
Background Glioblastoma (GBM) has poor prognosis despite aggressive treatment. Dendritic cell (DC) vaccines are promising, but widespread clinical use has not been achieved, possibly reflecting manufacturing issues of antigen choice and DC…
View article: Intrinsic Tendon Regeneration After Application of Purified Exosome Product: An In Vivo Study
Intrinsic Tendon Regeneration After Application of Purified Exosome Product: An In Vivo Study Open
Background: Tendons are primarily acellular, limiting their intrinsic regenerative capabilities. This limited regenerative potential contributes to delayed healing, rupture, and adhesion formation after tendon injury. Purpose: To determine…
View article: IMMU-15. HEPARIN INHIBITS THE EXTRACELLULAR VESICLE-MEDIATED INDUCTION OF IMMUNOSUPPRESSIVE MONOCYTES IN GLIOBLASTOMA
IMMU-15. HEPARIN INHIBITS THE EXTRACELLULAR VESICLE-MEDIATED INDUCTION OF IMMUNOSUPPRESSIVE MONOCYTES IN GLIOBLASTOMA Open
Glioblastoma (GBM) is the most common and fatal primary brain tumor in adults. The development of novel therapies is critical, as little has changed regarding the standard of care in nearly two decades. Immunotherapy holds much promise, as…
View article: The role of extracellular vesicles and PD-L1 in glioblastoma-mediated immunosuppressive monocyte induction
The role of extracellular vesicles and PD-L1 in glioblastoma-mediated immunosuppressive monocyte induction Open
Background Immunosuppression in glioblastoma (GBM) is an obstacle to effective immunotherapy. GBM-derived immunosuppressive monocytes are central to this. Programmed cell death ligand 1 (PD-L1) is an immune checkpoint molecule, expressed b…
View article: Novel strategy for manufacturing autologous dendritic cell/allogeneic tumor lysate vaccines for glioblastoma
Novel strategy for manufacturing autologous dendritic cell/allogeneic tumor lysate vaccines for glioblastoma Open
Background Glioblastoma, the most common primary malignant brain tumor, is nearly universally fatal by 5 years. Dendritic cell vaccines are promising but often limited clinically by antigen choice, dendritic cell potency, and/or manufactur…
View article: IMMU-36. THE ROLE OF PD-L1 IN GLIOBLASTOMA-DERIVED EXTRACELLULAR VESICLES IN THE INDUCTION OF IMMUNOSUPPRESSIVE MONOCYTES
IMMU-36. THE ROLE OF PD-L1 IN GLIOBLASTOMA-DERIVED EXTRACELLULAR VESICLES IN THE INDUCTION OF IMMUNOSUPPRESSIVE MONOCYTES Open
Glioblastoma (GBM) is the most common and lethal primary brain tumor, and novel therapeutic strategies that make a substantial impact on outcomes are sorely needed. Immunotherapies have shown great promise in the treatment of a number of c…
View article: Commonly Used Immunosuppressives Affect Mesenchymal Stem Cell Viability and Function: Should We Rethinking Clinical Trial Inclusion and Exclusion Criteria?
Commonly Used Immunosuppressives Affect Mesenchymal Stem Cell Viability and Function: Should We Rethinking Clinical Trial Inclusion and Exclusion Criteria? Open
Background Clinical trials utilizing mesenchymal stem cells (MCSs) for the treatment of perianal Crohn disease are expanding. Most enrolled Crohn patients are being actively treated with corticosteroids, immunomodulators, and biologic ther…
View article: Antitumor activity of novel pyrazole-based small molecular inhibitors of the STAT3 pathway in patient derived high grade glioma cells
Antitumor activity of novel pyrazole-based small molecular inhibitors of the STAT3 pathway in patient derived high grade glioma cells Open
Abnormal activation of signal transducer and activator of transcription 3 (STAT3) transcription factor has been observed in many human cancers with roles in tumor initiation, progression, drug resistance, angiogenesis and immunosuppression…
View article: Isolation and Analysis of Plasma-Derived Exosomes in Patients With Glioma
Isolation and Analysis of Plasma-Derived Exosomes in Patients With Glioma Open
Gliomas including glioblastoma (GBM) are the most common primary malignant brain tumors. Glioma extracellular vesicles (EVs) including exosomes have biological effects (e.g., immunosuppression) and contain tumor-specific cargo that could f…
View article: Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas
Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas Open
Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse Intrinsic Pontine Glioma (DIPG), which is the most aggressive form of pediatric glioma with a dire prognosis. DIPG are lethal …
View article: CBMT-09. ESTABLISHMENT AND IN VITRO CHARACTERIZATION OF A SPORADIC PEDIATRIC ATYPICAL MENINGIOMA CELL LINE
CBMT-09. ESTABLISHMENT AND IN VITRO CHARACTERIZATION OF A SPORADIC PEDIATRIC ATYPICAL MENINGIOMA CELL LINE Open
Meningiomas represent ~30% of primary neoplasms in adults but only 0.4–4.6% in children. Due to the paucity of cases, relatively few studies have addressed pediatric meningiomas and there are insufficient cell lines to conduct in vitro stu…
View article: INNV-16. miRNA SIGNATURE DERIVED FROM GBM PLASMA EXOSOMES AS A DIAGNOSTIC BIOMARKER
INNV-16. miRNA SIGNATURE DERIVED FROM GBM PLASMA EXOSOMES AS A DIAGNOSTIC BIOMARKER Open
Gliomas including glioblastoma (GBM) are the most common malignant brain tumors. Glioma extracellular vesicles (EVs), especially plasma exosomes, have biological effects such as mediating immunosuppression and contain signature tumor-speci…
View article: PATH-56. OPTIMIZED ISOLATION OF PLASMA EXTRACELLULAR VESICLES FOR USE AS POTENTIAL BIOMARKERS IN PATIENTS WITH GLIOBLASTOMA
PATH-56. OPTIMIZED ISOLATION OF PLASMA EXTRACELLULAR VESICLES FOR USE AS POTENTIAL BIOMARKERS IN PATIENTS WITH GLIOBLASTOMA Open
Glioblastoma (GBM) is the most common brain tumor and is nearly universally fatal within five years despite aggressive treatment. Tissue histopathology is required for definitive diagnosis. Imaging alone is inadequate to distinguish tumor …
View article: ATIM-13. ALLOGENEIC TUMOR LYSATE/AUTOLOGOUS DENDRITIC CELL VACCINES IN NEWLY DIAGNOSED GLIOBLASTOMA: RESULTS OF CLINICAL TRIAL MC1272
ATIM-13. ALLOGENEIC TUMOR LYSATE/AUTOLOGOUS DENDRITIC CELL VACCINES IN NEWLY DIAGNOSED GLIOBLASTOMA: RESULTS OF CLINICAL TRIAL MC1272 Open
INTRODUCTION: Dendritic cell (DC) vaccines for glioblastoma multiforme (GBM) have been promising in pre-clinical studies but widespread clinical translation has been hampered by issues related to immune editing for vaccines targeting speci…
View article: Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane
Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane Open
Glioblastoma is the most common primary tumor of the brain and has few long-term survivors. The local and systemic immunosuppressive environment created by glioblastoma allows it to evade immunosurveillance. Myeloid-derived suppressor cell…
View article: IMST-54. GLIOBLASTOMA EXTRACELLULAR VESICLES INDUCE IMMUNOSUPPRESSION VIA PD-L1
IMST-54. GLIOBLASTOMA EXTRACELLULAR VESICLES INDUCE IMMUNOSUPPRESSION VIA PD-L1 Open
Glioblastoma multiforme (GBM) induces potent immunosuppression both within the tumor and systemically. The mechanisms underlying this have not been fully elucidated. GBM shed large numbers of extracellular vesicles (EV’s). Here, we test th…