Timothy E. Riedel
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View article: Filter, heat, spin: A simple and inexpensive method for DNA preparation from freshwater for use in high-throughput molecular source tracking
Filter, heat, spin: A simple and inexpensive method for DNA preparation from freshwater for use in high-throughput molecular source tracking Open
Molecular source tracking (MST) can improve community health by enabling the identification of the source species of fecal bacteria contamination in waterways. However, widespread adoption of this method at a large scale is hindered by the…
View article: Fieldable isothermal nucleic acid test for rapid semi-quantitative visual readout of <i>Enterococci</i> in recreational waters
Fieldable isothermal nucleic acid test for rapid semi-quantitative visual readout of <i>Enterococci</i> in recreational waters Open
Enterococci are fecal indicator bacteria whose presence in water suggests the potential for gastrointestinal pathogens. Culture-based detection is slow and may require expensive apparatus and proprietary media. Molecular tests based on qPC…
View article: Adapting a LAMP Plasmodium vivax Malaria Diagnostic for Use in Low Resource Settings
Adapting a LAMP Plasmodium vivax Malaria Diagnostic for Use in Low Resource Settings Open
Malaria caused by the P. vivax parasite can be difficult to diagnose due to dormant phases and genetic variants. Regions such as Sub-Saharan Africa, South America, and Southeast Asia experience diagnostic accessibility issues due to the ‘g…
View article: A novel loop-mediated isothermal amplification (LAMP) diagnostic test for detecting<i>Salmonella enterica</i>serotype Typhi directly in raw milk
A novel loop-mediated isothermal amplification (LAMP) diagnostic test for detecting<i>Salmonella enterica</i>serotype Typhi directly in raw milk Open
Milk-transmitted outbreaks remain a significant issue in low-income countries due to unhygienic practices. There are no known easily accessible and cheap diagnostic tests that can detect S . Typhi in raw milk samples at high specificity, s…
View article: Filter, Heat, Spin: A Simple and Inexpensive Method for DNA Preparation from Freshwater for use in High-Throughput Molecular Source Tracking
Filter, Heat, Spin: A Simple and Inexpensive Method for DNA Preparation from Freshwater for use in High-Throughput Molecular Source Tracking Open
Molecular source tracking (MST) can improve community health by enabling the identification of the source species of fecal bacteria contamination in waterways. However, widespread adoption of this method at a large scale is hindered by the…
View article: Developing a User-Friendly Oropharyngeal HPV-16 Point-of-Care Diagnostic: HPV-16 Virus Detection in Oral Rinse Sample Matrix With Colorimetric Loop-Mediated Isothermal Amplification
Developing a User-Friendly Oropharyngeal HPV-16 Point-of-Care Diagnostic: HPV-16 Virus Detection in Oral Rinse Sample Matrix With Colorimetric Loop-Mediated Isothermal Amplification Open
Human papillomavirus type 16 (HPV-16) is a highly carcinogenic variant that is responsible for the majority of human oropharyngeal cancers. HPV-16 is critically under-tested, and there are currently no commercially available HPV-16 diagnos…
View article: Improved Diagnostic of Spotted Fevers via Loop-Mediated Isothermal Amplification with One Step Strand Displacement
Improved Diagnostic of Spotted Fevers via Loop-Mediated Isothermal Amplification with One Step Strand Displacement Open
1. Abstract Spotted fever rickettsiosis plagues countries around the world. One of the deadliest of this group, Rickettsia rickettsii , responsible for Rocky Mountain spotted fever, is an emerging tickborne illness in North America. The pr…
View article: Modification of blood-based (IgG) to salivary-based (IgA) ELISA for Inflammatory Bowel Disease Diagnostic: Tumor necrosis factor (TNF) alpha quantification
Modification of blood-based (IgG) to salivary-based (IgA) ELISA for Inflammatory Bowel Disease Diagnostic: Tumor necrosis factor (TNF) alpha quantification Open
Approximately 1.6 million people in the United States are struggling with Inflammatory bowel disease. Even though there are a number of diagnostic tools present, including MRI, CT scan, and laboratory tests, the public still lacks access t…
View article: High-Surety Isothermal Amplification and Detection of SARS-CoV-2
High-Surety Isothermal Amplification and Detection of SARS-CoV-2 Open
One of the key approaches to treatment and control of infectious diseases, such as COVID-19, is accurate and rapid diagnostics that is widely deployable in a timely and scalable manner. To achieve this, it is essential to go beyond the tra…
View article: High-surety isothermal amplification and detection of SARS-CoV-2, including with crude enzymes
High-surety isothermal amplification and detection of SARS-CoV-2, including with crude enzymes Open
Isothermal nucleic acid amplification tests (iNAT), such as loop-mediated isothermal amplification (LAMP), are good alternatives to polymerase chain reaction (PCR)-based amplification assays, especially for point-of-care and low resource u…
View article: Direct nucleic acid analysis of mosquitoes for high fidelity species identification and detection of Wolbachia using a cellphone
Direct nucleic acid analysis of mosquitoes for high fidelity species identification and detection of Wolbachia using a cellphone Open
Manipulation of natural mosquito populations using the endosymbiotic bacteria Wolbachia is being investigated as a novel strategy to reduce the burden of mosquito-borne viruses. To evaluate the efficacy of these interventions, it will be c…
View article: Direct nucleic acid analysis of mosquitoes for high fidelity species identification and detection of <i>Wolbachia</i> using a cellphone
Direct nucleic acid analysis of mosquitoes for high fidelity species identification and detection of <i>Wolbachia</i> using a cellphone Open
Manipulation of natural mosquito populations using the endosymbiotic bacteria Wolbachia is being investigated as a novel strategy to reduce the burden of mosquito-borne viruses. To evaluate the efficacy of these interventions, it will be c…