Timothy E. Yap
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View article: Correction: Yap et al. Real-Time Imaging of Retinal Ganglion Cell Apoptosis. Cells 2018, 7, 60
Correction: Yap et al. Real-Time Imaging of Retinal Ganglion Cell Apoptosis. Cells 2018, 7, 60 Open
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View article: Comparison of intraocular pressure profiles during the water drinking test and the modified diurnal tension curve
Comparison of intraocular pressure profiles during the water drinking test and the modified diurnal tension curve Open
Objectives To compare intraocular pressure (IOP) during the water drinking test (WDT) and modified diurnal tension curve (mDTC) in open-angle glaucoma (OAG) patients, using multimodal, observer-masked tonometry. Methods Open-angle glaucoma…
View article: Effects of COVID-19 pandemic on glaucoma appointment scheduling in a tertiary hospital in London, UK
Effects of COVID-19 pandemic on glaucoma appointment scheduling in a tertiary hospital in London, UK Open
Purpose To investigate the impact of the delay in patient appointments caused by the COVID-19 pandemic and the triage system on the glaucomatous disease of patients in a London tertiary hospital. Methods Observational retrospective study t…
View article: Endocyclophotocoagulation combined with phacoemulsification in surgically naive primary open-angle glaucoma: three-year results
Endocyclophotocoagulation combined with phacoemulsification in surgically naive primary open-angle glaucoma: three-year results Open
Objective To assess the safety and efficacy of endocyclophotocoagulation with phacoemulsification (phaco-ECP) in surgically naive, primary open-angle glaucoma (POAG). Methods A retrospective case series of patients undergoing phaco-ECP bet…
View article: Recent Advancements in the Medical Treatment of Diabetic Retinal Disease
Recent Advancements in the Medical Treatment of Diabetic Retinal Disease Open
Diabetic retinal disease remains one of the most common complications of diabetes mellitus (DM) and a leading cause of preventable blindness. The mainstay of management involves glycemic control, intravitreal, and laser therapy. However, i…
View article: A near-fatal consequence of chiropractor massage: massive stroke from carotid arterial dissection and bilateral vertebral arterial oedema
A near-fatal consequence of chiropractor massage: massive stroke from carotid arterial dissection and bilateral vertebral arterial oedema Open
A 35-year-old Chinese man with no risk factors for stroke presented with a 2-day history of expressive dysphasia and a 1-day history of right-sided weakness. The presentation was preceded by multiple sessions of neck, shoulder girdle and u…
View article: A Functional Radiological and Soft Tissue Classification to Predict Outcomes in Orbital Fracture Surgery in a Multidisciplinary “Real-World” Setting
A Functional Radiological and Soft Tissue Classification to Predict Outcomes in Orbital Fracture Surgery in a Multidisciplinary “Real-World” Setting Open
Purpose: The decision for open reduction and internal fixation (ORIF) of orbital fractures is usually based on clinical severity and soft tissue and bony findings. This study aimed to identify prognostic factors for a successful surgical o…
View article: Reflecting on Exchanged Students' Learning: Bedside Demonstration, Case Reporting and Clinical Reasoning
Reflecting on Exchanged Students' Learning: Bedside Demonstration, Case Reporting and Clinical Reasoning Open
Background : The increasing opportunities for medical students to participate in international, supervised and structured electives have been shown in our recent study, which enhanced students’ professionalism, cultural competence and clin…
View article: Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain
Cellular Consequences of Coenzyme Q10 Deficiency in Neurodegeneration of the Retina and Brain Open
Coenzyme Q10 (CoQ10) is a ubiquitous cofactor in the body, operating in the inner mitochondrial membrane, where it plays a vital role in the generation of adenosine triphosphate (ATP) through the electron transport chain (ETC). In addition…
View article: Detecting Apoptosis as a Clinical Endpoint for Proof of a Clinical Principle
Detecting Apoptosis as a Clinical Endpoint for Proof of a Clinical Principle Open
The transparent eye media represent a window through which to observe changes occurring in the retina during pathological processes. In contrast to visualising the extent of neurodegenerative damage that has already occurred, imaging an ac…
View article: Treating the whole glaucoma spectrum: A new treatment approach is required
Treating the whole glaucoma spectrum: A new treatment approach is required Open
Glaucoma is the leading cause of irreversible sight loss and predicted to affect 111.8 million people by 2040.1 It is caused by progressive death of retinal ganglion cells and loss of optic nerve function, with the potential to result in b…
View article: Neuroprotective Strategies in Glaucoma - Translation to Clinical Trials
Neuroprotective Strategies in Glaucoma - Translation to Clinical Trials Open
Neuroprotection in glaucoma is any medical treatment by which decline in visual function can be slowed or prevented by supporting the health and survival of neural cells, independent of lowering of intraocular pressure (IOP). This is achie…
View article: Translating research evidence into clinical practice: a reminder of important clinical lessons in management of resistant hypertension through a case study in general practice
Translating research evidence into clinical practice: a reminder of important clinical lessons in management of resistant hypertension through a case study in general practice Open
A case of a 59-year-old man with resistant hypertension, despite 8 months of non-pharmacological and pharmacological management up to maximal doses of triple antihypertensive therapy. Review of the literature found a study that reported im…
View article: A CNN-aided method to predict glaucoma progression using DARC (Detection of Apoptosing Retinal Cells)
A CNN-aided method to predict glaucoma progression using DARC (Detection of Apoptosing Retinal Cells) Open
A key objective in glaucoma is to identify those at risk of rapid progression and blindness. Recently, a novel first-in-man method for visualising apoptotic retinal cells called DARC (Detection-of-Apoptosing-Retinal-Cells) was reported. Th…
View article: Retinal correlates of psychiatric disorders
Retinal correlates of psychiatric disorders Open
Diagnosis and monitoring of psychiatric disorders rely heavily on subjective self-reports of clinical symptoms, which are complicated by the varying consistency of accounts reported by patients with an impaired mental state. Hence, more ob…
View article: Ophthalmic Research Lecture 2018: DARC as a Potential Surrogate Marker
Ophthalmic Research Lecture 2018: DARC as a Potential Surrogate Marker Open
Glaucoma is a progressive, neurodegenerative disease that is increasing in prevalence worldwide. There is a need to develop ways in which to diagnose the disease sooner and more reliably in order to prevent irreversible visual loss and mee…
View article: Retinal correlates of neurological disorders
Retinal correlates of neurological disorders Open
Considering the retina as an extension of the brain provides a platform from which to study diseases of the nervous system. Taking advantage of the clear optical media of the eye and ever-increasing resolution of modern imaging techniques,…
View article: Real-Time Imaging of Retinal Ganglion Cell Apoptosis
Real-Time Imaging of Retinal Ganglion Cell Apoptosis Open
Monitoring real-time apoptosis in-vivo is an unmet need of neurodegeneration science, both in clinical and research settings. For patients, earlier diagnosis before the onset of symptoms provides a window of time in which to instigate trea…
View article: Annexins in Glaucoma
Annexins in Glaucoma Open
Glaucoma is one of the leading causes of irreversible visual loss, which has been estimated to affect 3.5% of those over 40 years old and projected to affect a total of 112 million people by 2040. Such a dramatic increase in affected patie…
View article: Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound
Comparison of Corneal Epithelial Thickness Measurement Between Fourier-Domain OCT and Very High-Frequency Digital Ultrasound Open
PURPOSE: To compare measurements of corneal epithelial thickness using optical coherence tomography (OCT) and very high-frequency digital ultrasound (VHFDU). METHODS: Retrospective analysis of 189 virgin corneas and 175 post-laser refracti…