Timothy J. Ebner
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View article: Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges
Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges Open
View article: Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8)
Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8) Open
Spinocerebellar Ataxia Type 8 (SCA8) is an inherited neurodegenerative disease caused by a bidirectionally expressed CTG•CAG expansion mutation in the ATXN8 and ATXN8OS genes. While SCA8 patients have motor abnormalities, patients may also…
View article: Cortex-wide characterization of decision-making neural dynamics during spatial navigation
Cortex-wide characterization of decision-making neural dynamics during spatial navigation Open
Summary Decision-making during freely moving behaviors involves complex interactions among many cortical and subcortical regions. However, the spatiotemporal coordination across regions to generate a decision is less understood. Using a he…
View article: Brain-wide neural recordings in mice navigating physical spaces enabled by robotic neural recording headstages
Brain-wide neural recordings in mice navigating physical spaces enabled by robotic neural recording headstages Open
Technologies that can record neural activity at cellular resolution at multiple spatial and temporal scales are typically much larger than the animals that are being recorded from and are thus limited to recording from head-fixed subjects.…
View article: Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion
Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion Open
The role of the cerebral cortex in self-initiated versus sensory-driven movements is central to understanding volitional action. Whether the differences in these two movement classes are due to specific cortical areas versus more cortex-wi…
View article: Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8)
Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8) Open
Spinocerebellar Ataxia Type 8 (SCA8) is an inherited neurodegenerative disease caused by a bidirectionally expressed CTG●CAG expansion mutation in the ATXN-8 and ATXN8-OS genes. While primarily a motor disorder, psychiatric and cognitive s…
View article: Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges
Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges Open
Despite research illustrating the cerebellum may be a critical circuit element in processes beyond motor control, and growing evidence for a role of the cerebellum in a range of neurological disorders, including the epilepsies, remarkably …
View article: Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton
Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton Open
View article: Mesoscale Ca<sup>2+</sup>imaging reveals networks of Purkinje cell dendritic and somatic modulation, with divergent roles of activity versus correlation during behavior
Mesoscale Ca<sup>2+</sup>imaging reveals networks of Purkinje cell dendritic and somatic modulation, with divergent roles of activity versus correlation during behavior Open
A major challenge in cerebellar physiology is determining how the stereotypic, conserved circuitry of the cerebellar cortex, with its dominant parasagittal and transverse architectures, underlies its fundamental computations and contributi…
View article: Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton
Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton Open
Complex behaviors are mediated by neural computations occurring throughout the brain. In recent years, tremendous progress has been made in developing technologies that can record neural activity at cellular resolution at multiple spatial …
View article: Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally driven locomotion
Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally driven locomotion Open
The neural dynamics underlying self-initiated versus sensory driven movements is central to understanding volitional action. Upstream motor cortices are associated with the generation of internally-driven movements over externally-driven. …
View article: Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion
Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion Open
The neural dynamics underlying self-initiated versus sensory driven movements is central to understanding volitional action. Upstream motor cortices are associated with the generation of internally-driven movements over externally-driven. …
View article: Altered brain state during episodic dystonia in tottering mice decouples primary motor cortex from limb kinematics
Altered brain state during episodic dystonia in tottering mice decouples primary motor cortex from limb kinematics Open
Episodic Ataxia Type 2 (EA2) is a rare neurological disorder caused by a mutation in the CACNA1A gene, encoding the P/Q-type voltage-gated Ca 2+ channel important for neurotransmitter release. Patients with this channelopathy exhibit both …
View article: To be and not to be: wide-field Ca2+ imaging reveals neocortical functional segmentation combines stability and flexibility
To be and not to be: wide-field Ca2+ imaging reveals neocortical functional segmentation combines stability and flexibility Open
The stability and flexibility of the functional parcellation of the cerebral cortex is fundamental to how familiar and novel information is both represented and stored. We leveraged new advances in Ca2+ sensors and microscopy to understand…
View article: Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse
Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse Open
>2.5 million individuals in the United States suffer mild traumatic brain injuries (mTBI) annually. Mild TBI is characterized by a brief period of altered consciousness, without objective findings of anatomic injury on clinical imaging or …
View article: Wide-Field Calcium Imaging of Neuronal Network Dynamics In Vivo
Wide-Field Calcium Imaging of Neuronal Network Dynamics In Vivo Open
A central tenet of neuroscience is that sensory, motor, and cognitive behaviors are generated by the communications and interactions among neurons, distributed within and across anatomically and functionally distinct brain regions. Therefo…
View article: To be and not to be: Wide-field Ca<sup>2+</sup>imaging reveals neocortical functional segmentation combines stability and flexibility
To be and not to be: Wide-field Ca<sup>2+</sup>imaging reveals neocortical functional segmentation combines stability and flexibility Open
The stability and flexibility of the functional parcellation of the cerebral cortex is fundamental to how familiar and novel information is both represented and stored. We leveraged new advances in Ca 2+ sensors and microscopy to understan…
View article: Polymer Skulls With Integrated Transparent Electrode Arrays for Cortex‐Wide Opto‐Electrophysiological Recordings
Polymer Skulls With Integrated Transparent Electrode Arrays for Cortex‐Wide Opto‐Electrophysiological Recordings Open
Electrophysiology and optical imaging provide complementary neural sensing capabilities – electrophysiological recordings have high temporal resolution, while optical imaging allows recording of genetically‐defined populations at high spat…
View article: Cerebellar Representations of Errors and Internal Models
Cerebellar Representations of Errors and Internal Models Open
View article: Wide-field Calcium Imaging Reveals Widespread Changes in Cortical Connectivity Following Repetitive, Mild Traumatic Brain Injury in the Mouse
Wide-field Calcium Imaging Reveals Widespread Changes in Cortical Connectivity Following Repetitive, Mild Traumatic Brain Injury in the Mouse Open
The physiologic basis underlying the long-term consequences of repetitive, mild traumatic brain injury (mTBI) remains poorly understood. Mild traumatic brain injury often results in brief loss of consciousness, impaired attention and conce…
View article: Polymer skulls with integrated transparent electrode arrays for cortex-wide opto-electrophysiological recordings
Polymer skulls with integrated transparent electrode arrays for cortex-wide opto-electrophysiological recordings Open
Electrophysiological and optical imaging provide complementary neural sensing capabilities – electrophysiological recordings have the highest temporal resolution, while optical imaging allows recording the activities of genetically defined…
View article: Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits
Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits Open
View article: Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion
Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion Open
Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex’s role in motor behavior requires a mesoscopic-level description of the cortical regio…
View article: Through the looking glass: A review of cranial window technology for optical access to the brain
Through the looking glass: A review of cranial window technology for optical access to the brain Open
View article: PATH-02. CHARACTERIZATION OF FUNCTIONAL NETWORK EFFECTS IN THE CEREBRAL CORTEX DURING BRAIN TUMORIGENESIS IN THE MOUSE
PATH-02. CHARACTERIZATION OF FUNCTIONAL NETWORK EFFECTS IN THE CEREBRAL CORTEX DURING BRAIN TUMORIGENESIS IN THE MOUSE Open
INTRODUCTION Neuro-cognitive decline is near universal in glioblastoma patients and negatively impacts the quality of life for afflicted patients. Yet, there is little information on longitudinal effects of brain tumor growth on cerebral c…
View article: TMOD-10. EFFECT OF BRAIN TUMORIGENESIS ON CEREBRAL CORTICAL FUNCTIONAL CONNECTIVITY IN THE MOUSE
TMOD-10. EFFECT OF BRAIN TUMORIGENESIS ON CEREBRAL CORTICAL FUNCTIONAL CONNECTIVITY IN THE MOUSE Open
INTRODUCTION Neuro-cognitive decline is near universal in glioblastoma patients and negatively impacts the quality of life for afflicted patients. Yet, there is little information on longitudinal effects of brain tumor growth on cerebral c…
View article: Wide-Field Calcium Imaging of Dynamic Cortical Networks During Locomotion
Wide-Field Calcium Imaging of Dynamic Cortical Networks During Locomotion Open
Motor behavior results in widespread activation of the cerebral cortex. Therefore, fully understanding the cerebral cortex’s role in motor behavior requires a mesoscopic level description of the engaged cortical regions and their functiona…
View article: Cortex-wide neural interfacing via transparent polymer skulls
Cortex-wide neural interfacing via transparent polymer skulls Open
View article: Cerebellum, Predictions and Errors
Cerebellum, Predictions and Errors Open
Making predictions and validating the predictions against actual sensory information is thought to be one of the most fundamental functions of the nervous system. A growing body of evidence shows that the neural mechanisms controlling beha…
View article: How to Train Your… Mouse: Head-Fixed Mice Learning Cued Locomotion for Cerebral Cortical Network Imaging
How to Train Your… Mouse: Head-Fixed Mice Learning Cued Locomotion for Cerebral Cortical Network Imaging Open