Timothy C Jenkins
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View article: Watchful Waiting for Children With Acute Otitis Media: Frequency of Use and Outcomes in Clinical Practice
Watchful Waiting for Children With Acute Otitis Media: Frequency of Use and Outcomes in Clinical Practice Open
Among 140 579 pediatric acute otitis media (AOM) visits, watchful waiting was used in 15.6% of cases and was associated with similarly low rates of treatment failure and adverse events as immediate antibiotics. Scale up of watchful waiting…
View article: Interventions to Minimize Unnecessary Antibiotic Use for Acute Otitis Media: A Meta-Analysis
Interventions to Minimize Unnecessary Antibiotic Use for Acute Otitis Media: A Meta-Analysis Open
Backgrounds/Objectives: Acute otitis media (AOM) is the leading reason antibiotics are prescribed to children. Despite guidelines advocating for watchful waiting and shorter antibiotic durations, overprescribing remains a concern. This met…
View article: Variability in gastrointestinal multiplex PCR panel ordering in urgent care: a potential diagnostic stewardship target
Variability in gastrointestinal multiplex PCR panel ordering in urgent care: a potential diagnostic stewardship target Open
View article: Implementation of conditional reflex urine culturing decreases unnecessary antimicrobial use
Implementation of conditional reflex urine culturing decreases unnecessary antimicrobial use Open
Objective: To evaluate the impact of implementation of a conditional reflex urine culturing strategy on urine culture rates, antimicrobial use, and clinical outcomes in hospitalized adults. Design: Pre-post quasi-experimental study. Settin…
View article: The Take 5 Campaign: Effects of an Intervention to Promote Five-Day Durations of Antibiotic Therapy for Common Infections in Urgent Care
The Take 5 Campaign: Effects of an Intervention to Promote Five-Day Durations of Antibiotic Therapy for Common Infections in Urgent Care Open
Background We implemented an intervention to promote five-day durations of antibiotic therapy for common infections in urgent care. The objectives of this study were to evaluate the effects of this intervention on prescribed durations and …
View article: Differences in Antibiotic Prescribing Patterns for Children with Acute Otitis Media Based on Patient, Clinician, and Clinic Characteristics
Differences in Antibiotic Prescribing Patterns for Children with Acute Otitis Media Based on Patient, Clinician, and Clinic Characteristics Open
Corresponding Author Alex Plattner, MD, MBA; One Children’s Place, St. Louis, MO 63110; [email protected] Funding This project was funded under grant number 1R01HS029153-01 from the Agency for Healthcare Research and Quality (AHRQ), US D…
View article: Dalbavancin for Treatment of <i>Staphylococcus aureus</i> Bacteremia
Dalbavancin for Treatment of <i>Staphylococcus aureus</i> Bacteremia Open
Importance Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access. Objective To evaluate the efficacy and…
View article: Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations
Variability in Durations of Therapy for Gram-Negative Bloodstream Infections and Factors Associated With Prolonged Durations Open
Data on treatment durations for gram-negative bloodstream infections in clinical practice are limited. In this study of 4240 gram-negative bloodstream infection episodes during 2019 from 24 US hospitals, the median duration of therapy was …
View article: Combination therapy with fosfomycin for <i>Staphylococcus aureus</i> bacteraemia or endocarditis: a systematic review and meta-analysis of randomized trials
Combination therapy with fosfomycin for <i>Staphylococcus aureus</i> bacteraemia or endocarditis: a systematic review and meta-analysis of randomized trials Open
Background and objectives Fosfomycin combination therapy for Staphylococcus aureus bacteraemia or endocarditis has been evaluated, but studies were limited by small sample sizes. We sought to conduct a systematic review and meta-analysis o…
View article: Penicillin allergies and selection of intrapartum antibiotic prophylaxis against group B <i>Streptococcus</i> at a safety-net institution
Penicillin allergies and selection of intrapartum antibiotic prophylaxis against group B <i>Streptococcus</i> at a safety-net institution Open
Objectives To evaluate the rate of documented penicillin allergies in obstetric patients and to estimate the proportion of patients receiving inappropriate alternative intrapartum group B Streptococcus (GBS) prophylaxis. Methods This was a…
View article: P-1796. Uptake, Utilization, and Satisfaction of a Mobile Application Decision Support Tool to Enhance Antimicrobial Stewardship in Colorado
P-1796. Uptake, Utilization, and Satisfaction of a Mobile Application Decision Support Tool to Enhance Antimicrobial Stewardship in Colorado Open
Background Several barriers to antimicrobial stewardship (ASP) in various Colorado hospitals were previously identified, including lack of clinical pathways, antibiotic dosing knowledge in neonatal and pediatric populations, and understand…
View article: P-1583. Can Electronic Clinical Decision Support Systems Decrease Unnecessary Antibiotic use for Asymptomatic Bacteriuria?
P-1583. Can Electronic Clinical Decision Support Systems Decrease Unnecessary Antibiotic use for Asymptomatic Bacteriuria? Open
Background Asymptomatic bacteriuria is often treated unnecessarily with antibiotics. Restricting cultures to patients who meet specific urinalysis (UA) parameters has been shown to decrease urine culture rate; however, the impact of these …
View article: P-1703. Evaluation of Antibiotic Use for Dental Infections in Dental Clinics Associated with an Academic Safety Net Institution
P-1703. Evaluation of Antibiotic Use for Dental Infections in Dental Clinics Associated with an Academic Safety Net Institution Open
Background In 2019, the American Dental Association (ADA) issued guidance on diagnostic criteria and appropriate antibiotic regimens for dental pain and swelling. Limited data exists on adherence to these guidelines. This study aimed to ev…
View article: P-888. Variability in Durations of Therapy for Gram-Negative Bloodstream Infections Across U.S. Hospitals
P-888. Variability in Durations of Therapy for Gram-Negative Bloodstream Infections Across U.S. Hospitals Open
Background There is a paucity of data on durations of antibiotic therapy utilized in clinical practice for patients with Gram-negative bloodstream infections (GN-BSI). The objectives of this study were to describe treatment durations for p…
View article: P-851. Evaluation of a multifaceted intervention on the management of uncomplicated gram-negative bacteremia
P-851. Evaluation of a multifaceted intervention on the management of uncomplicated gram-negative bacteremia Open
Background Randomized, controlled trials found 7 days of antibiotics to be as effective as 14 days for the treatment of uncomplicated Gram-negative bacteremia. The routine use of repeat blood cultures for these uncomplicated infections is …
View article: P-94. Can Fluoroquinolones Be Used for the Treatment of Deep-Seated <i>Streptococcus anginosus</i> group Infections?
P-94. Can Fluoroquinolones Be Used for the Treatment of Deep-Seated <i>Streptococcus anginosus</i> group Infections? Open
Background Invasive infections caused by Streptococcus anginosus group are increasingly common. Some experts recommend against treatment with fluoroquinolone (FQs) dues to potential development of fluoroquinolone resistance; however, this …
View article: Hydrogen‐Borrowing‐Based Methods for the Construction of Quaternary Stereocentres
Hydrogen‐Borrowing‐Based Methods for the Construction of Quaternary Stereocentres Open
Compounds containing quaternary stereocentres are a valuable motif in biologically active compounds. Herein we present our strategy to utilise the hydrogen borrowing manifold to access α‐quaternary ketones via a tandem acceptorless dehydro…
View article: Hydrogen‐Borrowing‐Based Methods for the Construction of Quaternary Stereocentres
Hydrogen‐Borrowing‐Based Methods for the Construction of Quaternary Stereocentres Open
Compounds containing quaternary stereocentres are a valuable motif in biologically active compounds. Herein we present our strategy to utilise the hydrogen borrowing manifold to access α‐quaternary ketones via a tandem acceptorless dehydro…
View article: Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-experimental study
Standardization in the management of gram-negative bloodstream infections after implementation of a clinical care guideline at a large academic, safety-net institution: a quasi-experimental study Open
Objective: To evaluate the impact of implementing a clinical care guideline for uncomplicated gram-negative bloodstream infections (GN-BSI) within a health system. Design: Retrospective, quasi-experimental study. Setting: A large academic …
View article: Implementing with intention: advantages, challenges, and tactics to optimally utilize the AXR metric
Implementing with intention: advantages, challenges, and tactics to optimally utilize the AXR metric Open
Antibiotic utilization for respiratory conditions (AXR) is a new Healthcare Effectiveness Data & Information Set ® (HEDIS ® ) measure designed to complement disease-specific metrics to improve outpatient antibiotic prescribing. Unique chal…
View article: Yield of Fungal and Mycobacterial Cultures for Operative Specimens in Orthopedic Procedures: A Retrospective, Observational Cohort Study
Yield of Fungal and Mycobacterial Cultures for Operative Specimens in Orthopedic Procedures: A Retrospective, Observational Cohort Study Open
View article: Evaluation of Antibiotic Use for Dental-Related Infections in Dental Clinics Associated With an Academic Safety Net Institution
Evaluation of Antibiotic Use for Dental-Related Infections in Dental Clinics Associated With an Academic Safety Net Institution Open
This retrospective study found lower antibiotic prescribing rates by outpatient dentists than previous literature, but with deviations from guideline recommendations in antibiotic indications and durations of treatment for oral pain and sw…
View article: Durations of Antibiotic Treatment for Acute Otitis Media and Variability in Prescribed Durations Across Two Large Academic Health Systems
Durations of Antibiotic Treatment for Acute Otitis Media and Variability in Prescribed Durations Across Two Large Academic Health Systems Open
Background Acute otitis media (AOM) accounts for roughly 25% of antibiotics prescribed to children annually. Despite national guidelines that recommend short (5–7 days) durations of antibiotics for children 2 years and older with AOM, most…
View article: Cost-Effectiveness of Pediatric Conjunctivitis Management and Return to Childcare and School Strategies: A Comparative Study
Cost-Effectiveness of Pediatric Conjunctivitis Management and Return to Childcare and School Strategies: A Comparative Study Open
Background Infectious conjunctivitis affects 1 in 8 children annually, resulting in high ophthalmic antibiotic prescribing and absenteeism from childcare and school. We aimed to quantify the cost-effectiveness and annual savings of 3 evide…
View article: Clinical Outcomes Associated with Amoxicillin Treatment for Acute Otitis Media in Children
Clinical Outcomes Associated with Amoxicillin Treatment for Acute Otitis Media in Children Open
Background Acute otitis media (AOM) is the most common reason children are prescribed antibiotics. Bacteria that produce beta-lactamase are an increasingly frequent cause of AOM and may be resistant to amoxicillin, the currently recommende…
View article: Interventions to de-implement unnecessary antibiotic prescribing for ear infections (DISAPEAR Trial): protocol for a cluster-randomized trial
Interventions to de-implement unnecessary antibiotic prescribing for ear infections (DISAPEAR Trial): protocol for a cluster-randomized trial Open
View article: Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections
Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections Open
Importance Management of gram-negative bloodstream infections (GN-BSIs) with oral antibiotics is highly variable. Objective To examine the transition from intravenous (IV) to oral antibiotics, including selection, timing, and associated cl…
View article: Implementation of Outpatient Automated Stewardship Information System (OASIS<sup>©</sup>) audit and feedback in 2 healthcare systems
Implementation of Outpatient Automated Stewardship Information System (OASIS<sup>©</sup>) audit and feedback in 2 healthcare systems Open
View article: Issue Information
Issue Information Open
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View article: 1274. Long-term Sustainability of Improvements in Antibiotic Prescribing for Inpatient Skin and Soft Tissue Infections after Implementation of Local Treatment Guidelines
1274. Long-term Sustainability of Improvements in Antibiotic Prescribing for Inpatient Skin and Soft Tissue Infections after Implementation of Local Treatment Guidelines Open
Background Institutional guidelines for the management of inpatient skin and soft tissue infections (SSTIs) were implemented at an academic public safety-net hospital in 2009. This led to an immediate and marked decrease in unnecessary use…