Timothy M. Hughes
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View article: Associations of place‐based social determinants of health with biomarkers of Alzheimer's disease and related dementias
Associations of place‐based social determinants of health with biomarkers of Alzheimer's disease and related dementias Open
INTRODUCTION Relationships between place‐based social determinants of health (SDoH) and Alzheimer's disease and related dementias biomarkers are emerging. METHODS Linear regressions examined associations of area deprivation index (ADI), so…
View article: Association of Ankle-Brachial Index with Coronary and Extra-Coronary Calcification in Older Adults: ARIC Study
Association of Ankle-Brachial Index with Coronary and Extra-Coronary Calcification in Older Adults: ARIC Study Open
Aims To investigate potentially distinct associations of ankle brachial index (ABI), a marker of subclinical atherosclerosis, with calcification in different vascular beds and cardiac valves. Methods We studied 1,420 ARIC participants (mea…
View article: Carotid and regional arterial stiffness and dementia‐related imaging biomarkers in the Multi‐Ethnic Study of Atherosclerosis (MESA)
Carotid and regional arterial stiffness and dementia‐related imaging biomarkers in the Multi‐Ethnic Study of Atherosclerosis (MESA) Open
INTRODUCTION Arterial stiffness measured within various arterial beds may be differentially associated with neuroimaging biomarkers of dementia. METHODS We related carotid and regional (cardio‐ankle vascular index [CAVI] and heart‐ankle pu…
View article: Subclinical vascular burden in relation to cognitive decline and impairment: The Multi‐Ethnic Study of Atherosclerosis (MESA)
Subclinical vascular burden in relation to cognitive decline and impairment: The Multi‐Ethnic Study of Atherosclerosis (MESA) Open
INTRODUCTION Subclinical cardiovascular disorders may be differentially associated with cognitive function, decline, and impairment and point to pathways linking vascular disorders to dementia. METHODS The Multi‐Ethnic Study of Atheroscler…
View article: Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program
Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program Open
View article: Air pollution and cognitive performance in late life: the role of lipid profile – results from the Multi-Ethnic Study of Atherosclerosis (MESA)
Air pollution and cognitive performance in late life: the role of lipid profile – results from the Multi-Ethnic Study of Atherosclerosis (MESA) Open
View article: Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia
Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia Open
View article: The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment
The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment Open
Background Mild cognitive impairment (MCI) has been related to impairment in cerebrovascular perfusion and microstructural magnetic resonance imaging (MRI) parameters. However, the relationship between cerebrovascular perfusion and microst…
View article: Evaluation of plasma p‐tau217 for detecting amyloid pathology in a heterogeneous community‐based cohort
Evaluation of plasma p‐tau217 for detecting amyloid pathology in a heterogeneous community‐based cohort Open
INTRODUCTION Studies suggest excellent performance of plasma phosphorylated tau 217 (p‐tau217) for detecting amyloid pathology, though studies in more representative populations are needed to validate previously determined cutpoints. METHO…
View article: ACE trial design: Equol targeting estrogen receptor‐β in vascular and cognitive aging
ACE trial design: Equol targeting estrogen receptor‐β in vascular and cognitive aging Open
INTRODUCTION Equol, a gut microbiome‐derived metabolite of soy isoflavone daidzein, functions as a selective estrogen receptor beta (ERβ) agonist. In preclinical studies, it has demonstrated vascular protective and antioxidant effects, wit…
View article: Subclinical Myocardial Injury and Global Cognitive Performance
Subclinical Myocardial Injury and Global Cognitive Performance Open
View article: Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants
Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants Open
Brain structural volumes are highly heritable and are linked to multiple neuropsychological outcomes, including Alzheimer’s disease (AD). Genome-wide association studies have successfully identified genetic variants associated with intracr…
View article: Advancing Fair and Explainable Machine Learning for Neuroimaging Dementia Pattern Classification in Multi-Ethnic Populations
Advancing Fair and Explainable Machine Learning for Neuroimaging Dementia Pattern Classification in Multi-Ethnic Populations Open
Dementia, a degenerative disease affecting millions globally, is projected to triple by 2050. Early and precise diagnosis is essential for effective treatment and improved quality of life. However, current diagnostic approaches frequently …
View article: Organ Donation for Research Biobanking Among Historically Marginalized Racial and Ethnic Groups
Organ Donation for Research Biobanking Among Historically Marginalized Racial and Ethnic Groups Open
Importance Research biobanks of human cells and tissues, particularly tissues accessible only after death, are crucial for advancing the understanding of human pathophysiological function. Research biobanks are bereft of tissues from indiv…
View article: Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease‐Related Dementias Pathology: The Multi‐Ethnic Study of Atherosclerosis
Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease‐Related Dementias Pathology: The Multi‐Ethnic Study of Atherosclerosis Open
Background Arterial stiffness is associated with pathological changes underlying Alzheimer disease and related dementias. Total pulse wave velocity can be subdivided into 2 main mechanisms: structural arterial stiffness (S‐PWV) due to intr…
View article: 0107 A Data-Driven Multidimensional Approach Examining the Relationship Between Cognition and Sleep Composites in the Multi-Ethnic Study of Atherosclerosis
0107 A Data-Driven Multidimensional Approach Examining the Relationship Between Cognition and Sleep Composites in the Multi-Ethnic Study of Atherosclerosis Open
Introduction Sleep is critical for maintaining overall brain health and may influence the onset and perpetuation of cognitive impairment. Since sleep is a complex and multi-dimensional construct, we hypothesized that methods that incorpora…
View article: 0341 Mapping the Relationships Between Structural Brain MRI Characteristics and Sleep EEG Patterns
0341 Mapping the Relationships Between Structural Brain MRI Characteristics and Sleep EEG Patterns Open
Introduction While brain morphology is well-established as a key factor influencing overall brain function, little is known about how brain structural properties are associated with oscillatory activity, particularly during sleep. Methods …
View article: Epigenetic biomarkers of socioeconomic status are associated with age-related chronic diseases and mortality in older adults
Epigenetic biomarkers of socioeconomic status are associated with age-related chronic diseases and mortality in older adults Open
Later-life health is patterned by socioeconomic influences across the lifecourse. However, the pathways underlying the biological embedding of socioeconomic status (SES) and its consequences on downstream morbidity and mortality are not fu…
View article: Polygenic risk scores for incident dementia in the Multi-Ethnic Study of Atherosclerosis
Polygenic risk scores for incident dementia in the Multi-Ethnic Study of Atherosclerosis Open
Over 75 Alzheimer’s disease (AD) and dementia-associated variants have been identified through genome-wide association studies, but the utility of polygenic risk scores (PRS) for predicting AD and dementia in diverse and admixed population…
View article: Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer’s disease in a diverse cohort: MESA
Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer’s disease in a diverse cohort: MESA Open
INTRODUCTION Little is known about how Alzheimer’s disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers. METHODS The study involved 251 Wake Forest Multi-Ethnic Study of Atherosclerosis (MES…
View article: Associations of circulating T cell subsets with endothelial function: the Multi-Ethnic Study of Atherosclerosis
Associations of circulating T cell subsets with endothelial function: the Multi-Ethnic Study of Atherosclerosis Open
We investigated whether peripheral T cells were associated with endothelial function in a multi-ethnic cohort. No significant associations were observed between Th1 or CD4 + CD28-CD57 + T cells with endothelial function in the primarily an…
View article: Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population‐based studies
Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population‐based studies Open
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View article: Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease
Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease Open
View article: Evaluation of plasma p-tau217 for detecting amyloid pathology in a diverse and heterogeneous community-based cohort
Evaluation of plasma p-tau217 for detecting amyloid pathology in a diverse and heterogeneous community-based cohort Open
INTRODUCTION: Studies suggest excellent performance of plasma p-tau217 for detecting amyloid pathology, though studies in more diverse populations are needed to validate previously determined cutpoints. METHODS: Plasma p-tau217 utility for…
View article: Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults
Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults Open
Background Prior research linking myosteatosis with cognition in older adults has been conducted in relatively homogenous populations with narrow age ranges. We evaluated if abdominal myosteatosis was associated with processing speed in a …
View article: Proteomics-based aging clocks in midlife and late-life and risk of dementia
Proteomics-based aging clocks in midlife and late-life and risk of dementia Open
View article: Air Pollution and Cognitive Performance in Late Life: The Role of Lipid Profile – Results from the Multi-Ethnic Study of Atherosclerosis (Mesa)
Air Pollution and Cognitive Performance in Late Life: The Role of Lipid Profile – Results from the Multi-Ethnic Study of Atherosclerosis (Mesa) Open
View article: Subclinical vascular risk composites and dementia imaging biomarkers 17–20 years later in the Multi-Ethnic Study of Atherosclerosis (MESA)
Subclinical vascular risk composites and dementia imaging biomarkers 17–20 years later in the Multi-Ethnic Study of Atherosclerosis (MESA) Open
View article: Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis
Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis Open
Our findings illustrate participants with 2021 eGFR < 60 compared with those with eGFR > 90 mL/min/1.73 m2 have higher risk of dementia in both African American and non-African American participants, but not of stroke.
View article: Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis
Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis Open
Importance Metals are established neurotoxicants, but evidence of their association with cognitive performance at low chronic exposure levels is limited. Objective To investigate the association of urinary metal levels, individually and as…