Timothy N. Holt
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View article: 236 Preliminary analysis of the relationship between heart score and carcass value in Angus cattle.
236 Preliminary analysis of the relationship between heart score and carcass value in Angus cattle. Open
This study aimed to develop a preliminary understanding of the relationship between heart scores (HS) and carcass value in Angus steers. One significant economic consequence of right heart failure in cattle is mortality before slaughter; h…
View article: 322 Mid-finishing pulmonary arterial pressure compared to late-finishing pulmonary arterial pressure as indicators of heart score.
322 Mid-finishing pulmonary arterial pressure compared to late-finishing pulmonary arterial pressure as indicators of heart score. Open
Pulmonary arterial pressure measured in beef cattle at a year of age is used to indicate pulmonary hypertension and an individual’s susceptibility to high-altitude disease. When measured at 14 months of age, PAP is related to heart score, …
View article: PS-20 Investigating potential relationships among key selection metrics of feed efficiency, pulmonary arterial pressure, and fertility metrics in beef bulls at high elevation
PS-20 Investigating potential relationships among key selection metrics of feed efficiency, pulmonary arterial pressure, and fertility metrics in beef bulls at high elevation Open
It is well established that reproductive and feed efficiency of the bull greatly impact the economic viability of cow-calf operations. Another key factor influencing economic viability in the Mountain West, is mortality of calves due to hi…
View article: Employee perception of precision technology use at the dairy farm
Employee perception of precision technology use at the dairy farm Open
The adoption of precision technologies on dairy farms has increased significantly in recent decades, leading to the challenge of providing employees with resources to maximize the efficient use of these tools. The objective of this study w…
View article: 246 Evaluation of Live Growth Performance and Carcass Characteristics of Late Finishing Phase Beef Cattle with Varying Degrees of Pulmonary Hypertension
246 Evaluation of Live Growth Performance and Carcass Characteristics of Late Finishing Phase Beef Cattle with Varying Degrees of Pulmonary Hypertension Open
Late feedlot death caused by congestive heart failure has been quantified extensively through epidemiological studies however, these models do not consider losses or gains associated live growth performance, carcass quality, and consumer r…
View article: 126 Prevalence of Right Sided Heart Failure in Angus Influenced and Beef on Dairy Fattening Feedlot Cattle
126 Prevalence of Right Sided Heart Failure in Angus Influenced and Beef on Dairy Fattening Feedlot Cattle Open
Bovine Congestive Heart Failure (BCHF) exists in feedlot cattle at low to moderate elevations, but previous studies focused solely on beef cattle. The economic advantage of breeding beef sires to dairy dams results in an increase in the nu…
View article: 127 Genetic Correlations Between Systolic and Diastolic Pulmonary Arterial Pressure in Beef Cattle
127 Genetic Correlations Between Systolic and Diastolic Pulmonary Arterial Pressure in Beef Cattle Open
Pulmonary hypertension is a historical issue in high elevation beef production and is increasingly occurring in moderate elevation beef finishing systems (i.e., feedlots). Pulmonary arterial pressure (PAP) is the mean pressure (mmHg) measu…
View article: Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model
Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model Open
Using a large animal model and employing a comprehensive approach integrating hemodynamic, transcriptomic, proteomic, and immunohistochemical analyses, we examined the early (2 wk) effects of severe PH on the RV. We observed that RV remode…
View article: Genetic parameters for pulmonary arterial pressure, yearling performance, and carcass ultrasound traits in Angus cattle
Genetic parameters for pulmonary arterial pressure, yearling performance, and carcass ultrasound traits in Angus cattle Open
Pulmonary arterial pressure (PAP) can be used as an indicator of susceptibility to pulmonary hypertension and subsequent potential to develop right-sided heart failure (RHF). Previously reported heritability estimates of PAP have been mode…
View article: 17 Heritability Estimate of Heart Score
17 Heritability Estimate of Heart Score Open
Feedlot heart disease (FHD), also known as bovine congestive heart failure, affects feedlot cattle at low to moderate elevations. This disease can cause feedlot death and preliminary research suggests unfavorable influences on performance …
View article: 14 Effect of Pulmonary Arterial Pressure and Precipitation Interaction on Reproductive Performance in Angus Heifers in South Central Wyoming
14 Effect of Pulmonary Arterial Pressure and Precipitation Interaction on Reproductive Performance in Angus Heifers in South Central Wyoming Open
Variable precipitation in the western United States impacts forage availability, potentially influencing fertility. Furthermore, producers located above 1,500 meters contend with high altitude disease (HAD) due to reduced atmospheric oxyge…
View article: 7 Evaluation of Finishing Performance and Carcass Characteristics of Beef Heifers with Variable Degrees of Heart Failure Risk and Differing Reproductive Tract Type
7 Evaluation of Finishing Performance and Carcass Characteristics of Beef Heifers with Variable Degrees of Heart Failure Risk and Differing Reproductive Tract Type Open
Tremendous economic loss is attributed to high altitude disease mortality of calves in the Mountain West and Great Plains region. Additional economic losses may be associated with changes in feed efficiency and carcass quality in animals a…
View article: Sire differences within heart and heart fat score in beef cattle
Sire differences within heart and heart fat score in beef cattle Open
View article: Effect of pulmonary arterial pressure and annual precipitation on reproductive performance of Angus heifers in south central Wyoming
Effect of pulmonary arterial pressure and annual precipitation on reproductive performance of Angus heifers in south central Wyoming Open
View article: Yearling pulmonary arterial pressure at moderate elevations as a varied indicator for pulmonary arterial pressure at high elevations in beef bulls in Colorado
Yearling pulmonary arterial pressure at moderate elevations as a varied indicator for pulmonary arterial pressure at high elevations in beef bulls in Colorado Open
View article: Detecting Edgeworth Cycles
Detecting Edgeworth Cycles Open
We develop and test algorithms to detect "Edgeworth cycles," which are asymmetric price movements that have caused antitrust concerns in many countries. We formalize four existing methods and propose six new methods based on spectral analy…
View article: Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension
Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension Open
Pulmonary hypertension (PH) is an incurable condition in humans; driven by pulmonary vascular remodeling partially mediated by epigenetic mechanisms; and leading to right ventricular hypertrophy, failure, and death. We hypothesized that ta…
View article: Phenotypic relationships between heart score and feed efficiency, carcass, and pulmonary arterial pressure traits1
Phenotypic relationships between heart score and feed efficiency, carcass, and pulmonary arterial pressure traits1 Open
View article: Repeated measures of PAP at different elevations in beef bulls in Colorado1,2
Repeated measures of PAP at different elevations in beef bulls in Colorado1,2 Open
View article: Evaluation of the sensitivity of pulmonary arterial pressure to elevation using a reaction norm model in Angus Cattle
Evaluation of the sensitivity of pulmonary arterial pressure to elevation using a reaction norm model in Angus Cattle Open
Pulmonary arterial pressure (PAP) is a diagnostic measure used to determine an individual’s susceptibility to developing high-altitude disease. The importance of PAP measures collected at elevations lower than the intended breeding elevati…
View article: Review of digital anatomy, infectious causes of lameness, and regional intravenous perfusion in cattle
Review of digital anatomy, infectious causes of lameness, and regional intravenous perfusion in cattle Open
Digital disorders in cattle constitute the majority of lameness issues that bovine practitioners will encounter. Treatment of many digital infections in cattle can be facilitated in part by regional limb perfusions of either local anesthet…
View article: Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle
Characterizing the impact of altitude and finishing system on mean pulmonary arterial pressure and carcass characteristics in Angus cattle Open
View article: Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity‐associated pulmonary hypertension with left heart disease
Cardiopulmonary remodeling in fattened beef cattle: a naturally occurring large animal model of obesity‐associated pulmonary hypertension with left heart disease Open
The obesity epidemic in developed societies has led to increased cardiovascular diseases including pulmonary hypertension associated with left heart disease (PH‐LHD), the largest and fastest‐growing class of PH. Similar to obese humans, PH…
View article: Evaluation of moderate to high elevation effects on pulmonary arterial pressure measures in Angus cattle1
Evaluation of moderate to high elevation effects on pulmonary arterial pressure measures in Angus cattle1 Open
Altitude-induced pulmonary hypertension is a disease once thought to only occur at extremely high elevations (>1,600 m), but recently, it has been observed at moderate elevations of 1,200 to 1,600 m. Pulmonary arterial pressure (PAP) has b…
View article: The beta-adrenergic agonist zilpaterol hydrochloride may predispose feedlot cattle to cardiac remodeling and dysfunction
The beta-adrenergic agonist zilpaterol hydrochloride may predispose feedlot cattle to cardiac remodeling and dysfunction Open
Background: The aim of this study was to address producer concerns that the β2-adrenergic agonist zilpaterol hydrochloride, a bovine growth promotant, predisposes cattle to cardiac disease and death. Our objectives were to evaluate the eff…
View article: Laparoscopic inguinal hernioplasty in a ram
Laparoscopic inguinal hernioplasty in a ram Open
Case Description —A 4-month-old Hampshire ram underwent open right inguinal herniorrhaphy and unilateral castration following herniation that developed after a kick injury. Seven months later, the ram was reevaluated because of scrotal swe…
View article: Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension
Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension Open