Timothy O’Brien
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View article: An assessment of the functional state of endothelial colony forming cells from patients with diabetes mellitus and chronic limb threatening ischemia
An assessment of the functional state of endothelial colony forming cells from patients with diabetes mellitus and chronic limb threatening ischemia Open
Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral vascular disease which can lead to amputation with a high associated mortality rate. Endothelial colony forming cells (ECFCs) show potential as a cell therapy t…
View article: Intravenous Delivery of Mesenchymal Stromal Cells Reverses Müller Cell Endoplasmic Reticulum Stress in Diabetic Retinopathy
Intravenous Delivery of Mesenchymal Stromal Cells Reverses Müller Cell Endoplasmic Reticulum Stress in Diabetic Retinopathy Open
Background Mesenchymal stromal cells (MSCs) are being extensively studied as a disease-modifying therapy for complications of diabetes mellitus (DM) such as diabetic retinopathy (DR). However, the optimal treatment regimen remains unclear,…
View article: An Assessment of the Functional State of Endothelial Colony Forming Cells from Patients with Diabetes Mellitus and Chronic Limb Threatening Ischemia
An Assessment of the Functional State of Endothelial Colony Forming Cells from Patients with Diabetes Mellitus and Chronic Limb Threatening Ischemia Open
Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral vascular disease which can lead to amputation with a high associated mortality rate. Endothelial colony forming cells (ECFCs) show potential as a cell therapy t…
View article: Rapid and Simplified Induction of Spinal Motor Neurons From Human Induced Pluripotent Stem Cells
Rapid and Simplified Induction of Spinal Motor Neurons From Human Induced Pluripotent Stem Cells Open
Human induced pluripotent stem cell (hiPSC)-derived motor neurons (MNs) provide a critical source for the study of motor neuron diseases (MNDs), which has been hindered by the lack of appropriate disease models for many years. Although man…
View article: How much money is really left on the table? Reassessing the measurement of IPO underpricing
How much money is really left on the table? Reassessing the measurement of IPO underpricing Open
View article: miR-1, miR-133a, miR-29b and skeletal muscle fibrosis in chronic limb-threatening ischaemia
miR-1, miR-133a, miR-29b and skeletal muscle fibrosis in chronic limb-threatening ischaemia Open
Chronic limb-threatening ischaemia (CLTI), the most severe manifestation of peripheral arterial disease (PAD), is associated with a poor prognosis and high amputation rates. Despite novel therapeutic approaches being investigated, no signi…
View article: Polyethyleneimine facilitates the growth and electrophysiological characterization of iPSC-derived motor neurons
Polyethyleneimine facilitates the growth and electrophysiological characterization of iPSC-derived motor neurons Open
View article: Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long‐QT Syndrome Type 3
Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long‐QT Syndrome Type 3 Open
Background Long‐QT syndrome is a primary cardiac ion channelopathy predisposing a patient to ventricular arrhythmia through delayed repolarization on the resting ECG. We aimed to establish a patient‐specific, human induced pluripotent stem…
View article: Mesenchymal stromal cell transplantation ameliorates fibrosis and microRNA dysregulation in skeletal muscle ischemia
Mesenchymal stromal cell transplantation ameliorates fibrosis and microRNA dysregulation in skeletal muscle ischemia Open
Peripheral arterial disease (PAD) is associated with lower-extremity muscle wasting. Hallmark features of PAD-associated skeletal muscle pathology include loss of skeletal muscle mass, reduced strength and physical performance, increased i…
View article: Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects
Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects Open
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, leading to various vascular complications. Accumulating evidence indicates that endothelial colony-forming cells (ECFCs) have attractive prospects for repairing …
View article: CD4+ chronic lymphocytic leukemia in an 86‐year‐old male veteran: A case report
CD4+ chronic lymphocytic leukemia in an 86‐year‐old male veteran: A case report Open
CD4+ chronic lymphocytic leukemia (CLL) represents an extremely rare example of phenotypic aberrancy within CLL. We present a case of an 86‐year‐old male veteran with a history of multiple comorbidities who was incidentally diagnosed with …
View article: Mesenchymal stromal cells from people with osteoporosis are fewer, and defective in both osteogenic and adipogenic capacity
Mesenchymal stromal cells from people with osteoporosis are fewer, and defective in both osteogenic and adipogenic capacity Open
Aim: Osteoporosis (OP) is caused by imbalanced bone remodelling homeostasis. It is highly prevalent, especially in post-menopausal women, resulting in high risk of fracture and morbidity. Mesenchymal stromal cells (MSCs) are osteoblast pro…
View article: Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy
Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy Open
View article: Clinical potential of plasma-functionalized graphene oxide ultrathin sheets for bone and blood vessel regeneration: Insights from cellular and animal models
Clinical potential of plasma-functionalized graphene oxide ultrathin sheets for bone and blood vessel regeneration: Insights from cellular and animal models Open
View article: miR-1, miR-133a, miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia.
miR-1, miR-133a, miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia. Open
Chronic limb-threatening ischaemia (CLTI), the most severe manifestation of peripheral arterial disease (PAD), is associated with a poor prognosis and high amputation rates. Despite novel therapeutics approaches being investigated, no sign…
View article: Recent advances in endothelial colony-forming cells: from the transcriptomic perspective
Recent advances in endothelial colony-forming cells: from the transcriptomic perspective Open
Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant proliferative and angiogenic ability. ECFCs are a promising treatment option for various diseases, such as ischemic heart disease and peripheral…
View article: Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy
Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy Open
View article: Mesenchymal Stromal Cell Transplantation Ameliorates Fibrosis and Dysregulated microRNA Signature Associated with Ischaemic Skeletal Muscle Damage.
Mesenchymal Stromal Cell Transplantation Ameliorates Fibrosis and Dysregulated microRNA Signature Associated with Ischaemic Skeletal Muscle Damage. Open
Peripheral arterial disease (PAD) is strongly associated with lower-extremity muscle wasting. Hallmark features of PAD associated skeletal muscle pathology include a loss of skeletal muscle mass, reduced strength and physical performance, …
View article: miR-1, miR-133a, and miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia.
miR-1, miR-133a, and miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia. Open
Background . Chronic limb-threatening ischaemia (CLTI) is the most severe manifestation of peripheral arterial disease (PAD), and is associated with poor prognosis and high amputation rates. Novel therapeutic approaches are currently being…
View article: Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury
Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury Open
View article: Polyethyleneimine facilitates the growth and electrophysiological characterization of motor neurons
Polyethyleneimine facilitates the growth and electrophysiological characterization of motor neurons Open
Background Induced pluripotent stem cell (iPSC) technology, in combination with electrophysiological characterization via multielectrode array (MEA), has facilitated the utilization of iPSC-derived motor neurons (MNs) as highly valuable mo…
View article: Factors associated with weight loss and health gains in a structured lifestyle modification programme for adults with severe obesity: a prospective cohort study
Factors associated with weight loss and health gains in a structured lifestyle modification programme for adults with severe obesity: a prospective cohort study Open
Background Individual responses to behavioural weight loss interventions can vary significantly, and a better understanding of the factors associated with successful treatment might help to target interventions for those who will benefit t…
View article: Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality
Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality Open
View article: Using Ribonucleoprotein-based CRISPR/Cas9 to Edit Single Nucleotide on Human Induced Pluripotent Stem Cells to Model Type 3 Long QT Syndrome (SCN5A±)
Using Ribonucleoprotein-based CRISPR/Cas9 to Edit Single Nucleotide on Human Induced Pluripotent Stem Cells to Model Type 3 Long QT Syndrome (SCN5A±) Open
View article: Generation of three induced pluripotent stem cell lines from a patient with KCNQ2 developmental and epileptic encephalopathy as a result of the pathogenic variant c.881C > T; p.Ala294Val (NUIGi059-A, NUIGi059-B, NUIGi059-C) and 3 healthy controls (NUIGi060-A, NUIGi060-B, NUIGi060-C)
Generation of three induced pluripotent stem cell lines from a patient with KCNQ2 developmental and epileptic encephalopathy as a result of the pathogenic variant c.881C > T; p.Ala294Val (NUIGi059-A, NUIGi059-B, NUIGi059-C) and 3 healthy controls (NUIGi060-A, NUIGi060-B, NUIGi060-C) Open
Developmental and epileptic encephalopathies (DEEs) are a group of severe, early-onset epilepsies which are often caused by genetic mutations in ion channels. Mutations in KCNQ2, which encodes the voltage-gated potassium channel Kv7.2, is …
View article: Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality
Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality Open
Background Extracellular vesicles (EV) are considered a cell-free alternative to mesenchymal stromal cell (MSC) therapy. Numerous reports describe the efficacy of EV in conferring immunomodulation and promoting angiogenesis, yet others rep…
View article: A novel protocol to derive cervical motor neurons from induced pluripotent stem cells for amyotrophic lateral sclerosis
A novel protocol to derive cervical motor neurons from induced pluripotent stem cells for amyotrophic lateral sclerosis Open
View article: Carrageenan as a macromolecular crowding agent in human umbilical cord derived mesenchymal stromal cell culture
Carrageenan as a macromolecular crowding agent in human umbilical cord derived mesenchymal stromal cell culture Open
Cell sheet tissue engineering requires prolonged in vitro culture for the development of implantable devices. Unfortunately, lengthy in vitro culture is associated with cell phenotype loss and substantially higher cost of goods, which coll…
View article: Safety and Preliminary Efficacy of Mesenchymal Stromal Cell (ORBCEL-M) Therapy in Diabetic Kidney Disease: A Randomized Clinical Trial (NEPHSTROM)
Safety and Preliminary Efficacy of Mesenchymal Stromal Cell (ORBCEL-M) Therapy in Diabetic Kidney Disease: A Randomized Clinical Trial (NEPHSTROM) Open
Significance Statement Mesenchymal stromal cells (MSCs) may offer a novel therapy for diabetic kidney disease (DKD), although clinical translation of this approach has been limited. The authors present findings from the first, lowest dose …
View article: Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy
Human umbilical cord-derived mesenchymal stromal cells improve myocardial fibrosis and restore miRNA-133a expression in diabetic cardiomyopathy Open
Background: Diabetic cardiomyopathy (DCM) is a serious health-threatening diabetic complication characterized by myocardial fibrosis and abnormal cardiac function. Human umbilical cord mesenchymal stromal cells (hUC-MSCs) are considered as…