Timothy Pickles
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View article: Picture perfect: study protocol for assessing the accuracy, feasibility and acceptability of intraoral photographs captured by parents for remote dental screening in children – an observational mixed-methods study
Picture perfect: study protocol for assessing the accuracy, feasibility and acceptability of intraoral photographs captured by parents for remote dental screening in children – an observational mixed-methods study Open
Background Children with limited access to dental care can be negatively impacted by reduced frequency of oral health monitoring, delays in diagnosis of dental disease and increased waits for dental care, resulting in them experiencing mor…
View article: Assessing the content validity of a Patient Reported Outcome Measure item pool for Rheumatoid Arthritis Disease Activity using cognitive interviews
Assessing the content validity of a Patient Reported Outcome Measure item pool for Rheumatoid Arthritis Disease Activity using cognitive interviews Open
Objectives Using Rasch measurement theory, an item pool of 12 questions has been identified, covering tenderness and swelling, disease activity, pain, physical functioning and stiffness for assessing the construct of RA disease activity. T…
View article: Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis
Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis Open
Introduction: The central nervous system (CNS) contributes to pain perception across musculoskeletal conditions. The central aspects of pain (CAP) questionnaire captures a single score associated with quantitative sensory testing (QST) evi…
View article: The Validation of the ‘CARe Burn Scale: Parent/Caregiver Form’—A Patient Reported Outcome Measure (PROM) Using Rasch Measurement Theory (RMT) to Assess Quality of Life for Parents or Caregivers Supporting a Child with a Burn Injury
The Validation of the ‘CARe Burn Scale: Parent/Caregiver Form’—A Patient Reported Outcome Measure (PROM) Using Rasch Measurement Theory (RMT) to Assess Quality of Life for Parents or Caregivers Supporting a Child with a Burn Injury Open
A PROM is a measure of patient needs and therapeutic progress. This paper outlines the validation of the CARe Burn Scale: Parent/Caregiver Form, a PROM that measures quality of life in parents/caregivers supporting a child with a burn inju…
View article: Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: Rasch measurement theory to identify items and domains
Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: Rasch measurement theory to identify items and domains Open
Objectives Disease activity (DA) monitoring is a standard of care in RA. There is demand for achieving this through patient-reported outcome measures (PROMs). The aim of this study was to determine which items could be used to measure the …
View article: Minimal important difference of pain numeric rating scale in patients with hidradenitis suppurativa: results from THESEUS
Minimal important difference of pain numeric rating scale in patients with hidradenitis suppurativa: results from THESEUS Open
Patient-reported outcomes collected in THESEUS study can be used to estimate a minimal important difference of 1 for a current pain numeric rating scale in a sample of patients with hidradenitis suppurativa.
View article: Measurement properties and interpretability of the Patient-Reported Impact of Dermatological Diseases (PRIDD) measure
Measurement properties and interpretability of the Patient-Reported Impact of Dermatological Diseases (PRIDD) measure Open
Background Patient-reported outcome measures (PROMs) are crucial in assessing the impact of dermatological conditions on people’s lives, but the existing dermatology-specific PROMs are not recommended for use, according to COSMIN. We devel…
View article: Evolving and evaluating the OMERACT fellows program: insights and implications from OMERACT 2023 fellows
Evolving and evaluating the OMERACT fellows program: insights and implications from OMERACT 2023 fellows Open
View article: Referee report. For: Developing a measure of participant experience of trials: qualitative study and cognitive testing [version 1; peer review: 1 approved with reservations]
Referee report. For: Developing a measure of participant experience of trials: qualitative study and cognitive testing [version 1; peer review: 1 approved with reservations] Open
View article: Exploring the complexities of pain phenotypes: OMERACT 2023 chronic pain working group workshop
Exploring the complexities of pain phenotypes: OMERACT 2023 chronic pain working group workshop Open
There is need for a standardized pain measure that can differentiate underlying pain mechanisms.
View article: Further refinement of the Patient-Reported Impact of Dermatological Diseases (PRIDD) measure using classical test theory and item response theory
Further refinement of the Patient-Reported Impact of Dermatological Diseases (PRIDD) measure using classical test theory and item response theory Open
Background Existing dermatology-specific Patient-Reported Outcome Measures (PROMs) do not fully capture the substantial physical, psychological and social impact of dermatological conditions on patients’ lives and are not recommended for u…
View article: Pragmatic randomised controlled trial of guided self-help versus individual cognitive behavioural therapy with a trauma focus for post-traumatic stress disorder (RAPID)
Pragmatic randomised controlled trial of guided self-help versus individual cognitive behavioural therapy with a trauma focus for post-traumatic stress disorder (RAPID) Open
Background Guided self-help has been shown to be effective for other mental conditions and, if effective for post-traumatic stress disorder, would offer a time-efficient and accessible treatment option, with the potential to reduce waiting…
View article: P035 Patient-reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory to achieve more meaningful measurement
P035 Patient-reported outcome measures for rheumatoid arthritis disease activity: using Rasch measurement theory to achieve more meaningful measurement Open
Background/Aims Disease activity (DA) monitoring is a standard of care in rheumatoid arthritis (RA), and there is demand for achieving this through patient-reported outcome measures (PROMs). A systematic review of PROMs for RA DA following…
View article: Proceedings of the 6th National Patient Reported Outcome Measures (PROMs) Annual UK Research Virtual Conference, Bridgend, Wales 2022
Proceedings of the 6th National Patient Reported Outcome Measures (PROMs) Annual UK Research Virtual Conference, Bridgend, Wales 2022 Open
View article: Public attitudes towards the use of novel technologies in their future healthcare: a UK survey
Public attitudes towards the use of novel technologies in their future healthcare: a UK survey Open
Background Innovation in healthcare technologies can result in more convenient and effective treatment that is less costly, but a persistent challenge to widespread adoption in health and social care is end user acceptability. The purpose …
View article: AZTEC—azithromycin therapy for prevention of chronic lung disease of prematurity: a statistical analysis plan for clinical outcomes
AZTEC—azithromycin therapy for prevention of chronic lung disease of prematurity: a statistical analysis plan for clinical outcomes Open
View article: Guided, internet based, cognitive behavioural therapy for post-traumatic stress disorder: pragmatic, multicentre, randomised controlled non-inferiority trial (RAPID)
Guided, internet based, cognitive behavioural therapy for post-traumatic stress disorder: pragmatic, multicentre, randomised controlled non-inferiority trial (RAPID) Open
Objective To determine if guided internet based cognitive behavioural therapy with a trauma focus (CBT-TF) is non-inferior to individual face-to-face CBT-TF for mild to moderate post-traumatic stress disorder (PTSD) to one traumatic event.…
View article: P089 Patient-reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines
P089 Patient-reported outcome measures for rheumatoid arthritis disease activity: a systematic review following COSMIN guidelines Open
Background/Aims The standard measurement instruments for assessing Rheumatoid Arthritis (RA) disease activity (DA) are the Disease Activity Score with 28-Joint Count, Simple Disease Activity Index and Clinical Disease Activity Index, which…
View article: The CARe Burn Scale—Adult Form: Identifying the Responsiveness and Minimal Important Difference (MID) Values of a Patient Reported Outcome Measure (PROM) to Assess Quality of Life for Adults with a Burn Injury
The CARe Burn Scale—Adult Form: Identifying the Responsiveness and Minimal Important Difference (MID) Values of a Patient Reported Outcome Measure (PROM) to Assess Quality of Life for Adults with a Burn Injury Open
The CARe Burn Scales are a suite of burn-specific PROMs for adults, children, young people, and parents affected by burns. This study aimed to determine the responsiveness and minimal important difference (MID) values of the Adult Form for…
View article: Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: a systematic review following COSMIN guidelines
Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: a systematic review following COSMIN guidelines Open
Background The current standard of care in rheumatoid arthritis (RA) requires regular assessment of disease activity (DA). All standard RA DA measurement instruments require joint counts to be undertaken by a healthcare professional with/w…
View article: Public Attitudes Towards the Use of Novel Technologies in Their Future Healthcare: A UK Survey
Public Attitudes Towards the Use of Novel Technologies in Their Future Healthcare: A UK Survey Open
Background Innovation in healthcare technologies can result in more convenient and effective treatment that is less costly, but a persistent challenge to widespread adoption in health and social care is end user acceptability. The purpose …
View article: Public attitudes towards the use of novel technologies in their future healthcare: A UK survey
Public attitudes towards the use of novel technologies in their future healthcare: A UK survey Open
Background Innovation in healthcare technologies can result in more convenient and effective treatment that is less costly, but a persistent challenge to widespread adoption in health and social care is end user acceptability. The purpose …
View article: Observational study to estimate the proportion of surgical site infection following excision of ulcerated skin tumours (OASIS study)
Observational study to estimate the proportion of surgical site infection following excision of ulcerated skin tumours (OASIS study) Open
This prospective evaluation of SSI identified with the WHQ following excision of ulcerated skin cancers demonstrated a high proportion with SSI. The WHQ was acceptable to patients; however, further evaluation is required to ensure validity…
View article: Testing the Responsiveness of and Defining Minimal Important Difference (MID) Values for the CARe Burn Scales: Patient-Reported Outcome Measures to Assess Quality of Life for Children and Young People Affected by Burn Injuries, and Their Parents/Caregivers
Testing the Responsiveness of and Defining Minimal Important Difference (MID) Values for the CARe Burn Scales: Patient-Reported Outcome Measures to Assess Quality of Life for Children and Young People Affected by Burn Injuries, and Their Parents/Caregivers Open
The CARe Burn Scales are a portfolio of burn-specific PROMs for people affected by burns, including a Child Form (for children < 8 years (parent-proxy)), a Young Person Form (for young people aged 8–17 years), an Adult Form, and a Parent F…
View article: Cost-effectiveness of home versus hospital management of children at onset of type 1 diabetes: the DECIDE randomised controlled trial
Cost-effectiveness of home versus hospital management of children at onset of type 1 diabetes: the DECIDE randomised controlled trial Open
Objective The aim of this economic evaluation was to assess whether home management could represent a cost-effective strategy in the patient pathway of type 1 diabetes (T1D). This is based on the Delivering Early Care In Diabetes Evaluatio…
View article: Training results in increased practitioner confidence and identification of depression in people with low vision: a mixed methods study
Training results in increased practitioner confidence and identification of depression in people with low vision: a mixed methods study Open
Purpose The prevalence of depression in people with low vision is high and often goes undiagnosed. There is the potential for those who provide low vision services to perform concurrent depression screening. However, prior training in depr…
View article: Urinary Stones and Intervention Quality of Life (USIQoL): Development and Validation of a New Core Universal Patient-reported Outcome Measure for Urinary Calculi
Urinary Stones and Intervention Quality of Life (USIQoL): Development and Validation of a New Core Universal Patient-reported Outcome Measure for Urinary Calculi Open
View article: Patient-Reported Outcome Measures in Dermatology: A Systematic Review
Patient-Reported Outcome Measures in Dermatology: A Systematic Review Open
By relying on data from existing patient-reported outcome measures of quality of life, the true impact of skin conditions on patients' lives may be underestimated. This study systematically reviewed all dermatology-specific (used across sk…
View article: Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants
Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants Open
Introduction Chronic lung disease of prematurity (CLD), also known as bronchopulmonary dysplasia (BPD), is a cause of significant respiratory morbidity in childhood and beyond. Coupled with lung immaturity, infections (especially by Ureapl…
View article: The development and validation of the CARe Burn Scale: Child Form: a parent-proxy-reported outcome measure assessing quality of life for children aged 8 years and under living with a burn injury
The development and validation of the CARe Burn Scale: Child Form: a parent-proxy-reported outcome measure assessing quality of life for children aged 8 years and under living with a burn injury Open