Timothy Qi
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View article: Optimizing Clinical Translation of Bispecific T‐cell Engagers through Context Unification with a Quantitative Systems Pharmacology Model
Optimizing Clinical Translation of Bispecific T‐cell Engagers through Context Unification with a Quantitative Systems Pharmacology Model Open
Bispecific T-cell engagers (bsTCEs) have emerged as a promising class of cancer immunotherapy. BsTCEs enable physical connections between T cells and tumor cells to enhance T-cell activity against cancer. Despite several marketing approval…
View article: Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case study
Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case study Open
View article: Development of bispecific T cell engagers: harnessing quantitative systems pharmacology
Development of bispecific T cell engagers: harnessing quantitative systems pharmacology Open
View article: Embracing Project Optimus: Can we Leverage Evolutionary Theory to Optimize Dosing in Oncology?
Embracing Project Optimus: Can we Leverage Evolutionary Theory to Optimize Dosing in Oncology? Open
View article: Optimizing Clinical Translation of Bispecific T Cell Engagers through Context Unification with a Quantitative Systems Pharmacology Model
Optimizing Clinical Translation of Bispecific T Cell Engagers through Context Unification with a Quantitative Systems Pharmacology Model Open
View article: Development of bispecific T cell engagers: harnessing quantitative systems pharmacology
Development of bispecific T cell engagers: harnessing quantitative systems pharmacology Open
View article: Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance
Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance Open
Effector T cells need to form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most T cell-based cancer immunotherapies. However, the…
View article: Incorporating lesion-to-lesion heterogeneity into early oncology decision making
Incorporating lesion-to-lesion heterogeneity into early oncology decision making Open
RECISTv1.1 (Response Evaluation Criteria In Solid Tumors) is the most commonly used response grading criteria in early oncology trials. In this perspective, we argue that RECISTv1.1 is ambiguous regarding lesion-to-lesion variation that ca…
View article: A multispecies framework for modeling adaptive immunity and immunotherapy in cancer
A multispecies framework for modeling adaptive immunity and immunotherapy in cancer Open
Predator-prey theory is commonly used to describe tumor growth in the presence of selective pressure from the adaptive immune system. These interactions are mediated by the tumor immunopeptidome (what the tumor “shows” the body) and the T-…
View article: Incorporating lesion-to-lesion heterogeneity into early oncology decision making
Incorporating lesion-to-lesion heterogeneity into early oncology decision making Open
RECISTv1.1 (Response Evaluation Criteria In Solid Tumors) is the most commonly used response grading criteria in early oncology trials. In this perspective, we argue that RECISTv1.1 is ambiguous regarding lesion-to-lesion variation that ca…
View article: Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance
Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance Open
Effector T cells need to form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most T cell-based cancer immunotherapies. However, the…
View article: Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case study
Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case study Open
The platform can dissect sources of variability in response to target therapy, which may facilitate decision-making during drug development.
View article: A multispecies framework for modeling adaptive immunity and immunotherapy in cancer
A multispecies framework for modeling adaptive immunity and immunotherapy in cancer Open
Predator-prey theory is commonly used to describe tumor growth in the presence of selective pressure from the adaptive immune system. These interactions are mediated by the tumor immunopeptidome (what the tumor “shows” the body) and the T-…
View article: Author response: Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance
Author response: Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance Open
View article: Virtual clinical trials: A tool for predicting patients who may benefit from treatment beyond progression with pembrolizumab in non‐small cell lung cancer
Virtual clinical trials: A tool for predicting patients who may benefit from treatment beyond progression with pembrolizumab in non‐small cell lung cancer Open
Enrolling patients in immunotherapy clinical trials is becoming increasingly competitive. Virtual clinical trials can help investigators answer key questions despite this. For example, pembrolizumab is the recommended first‐line treatment …
View article: Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case study
Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case study Open
Background and Purpose: Despite their use to treat cancers with specific genetic aberrations, targeted therapies elicit heterogeneous responses. Sources of variability are critical to targeted therapy drug development, yet there exists no …
View article: Embracing Project Optimus: Can we Leverage Evolutionary Theory to Optimize Dosing in Oncology?
Embracing Project Optimus: Can we Leverage Evolutionary Theory to Optimize Dosing in Oncology? Open
View article: Cellular kinetics: A clinical and computational review of CAR-T cell pharmacology
Cellular kinetics: A clinical and computational review of CAR-T cell pharmacology Open
View article: Identification of non-small cell lung cancer (NSCLC) patients who benefit from treatment beyond progression with pembrolizumab from individual lesion response dynamics
Identification of non-small cell lung cancer (NSCLC) patients who benefit from treatment beyond progression with pembrolizumab from individual lesion response dynamics Open
Background Pembrolizumab is the recommended first-line treatment for non-small cell lung cancer (NSCLC) with no driver alterations and PD-L1 Tumor Proportion Score (TPS) ≥ 50%. Salvage therapies for patients who develop resistance in this …
View article: Population Dynamics of Immunological Synapse Formation Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Treatment Resistance
Population Dynamics of Immunological Synapse Formation Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Treatment Resistance Open
Effector T cells form immunological synapses (IS) with recognized target cells to elicit cytolytic effects. Facilitating IS formation is the principal pharmacological action of most T cell-based cancer immunotherapies. However, the dynamic…
View article: A multispecies framework for modeling adaptive immunity and immunotherapy in cancer
A multispecies framework for modeling adaptive immunity and immunotherapy in cancer Open
Predator-prey theory is commonly used to approximately describe tumor growth in the presence of selective pressure from the adaptive immune system. These interactions are mediated by the tumor immunopeptidome (what the tumor “shows” the bo…
View article: Speed and Location Both Matter: Antigen Stimulus Dynamics Controls CAR-T Cell Response
Speed and Location Both Matter: Antigen Stimulus Dynamics Controls CAR-T Cell Response Open
Despite the success in B-cell malignancies, chimeric antigen receptor (CAR)-T cell therapies have not yet demonstrated consistent efficacy across all patients and tumor types, particularly against solid tumors. Higher rates of T cell exhau…
View article: In Translation: FcRn across the Therapeutic Spectrum
In Translation: FcRn across the Therapeutic Spectrum Open
As an essential modulator of IgG disposition, the neonatal Fc receptor (FcRn) governs the pharmacokinetics and functions many therapeutic modalities. In this review, we thoroughly reexamine the hitherto elucidated biological and thermodyna…
View article: Spastin mutations impair coordination between lipid droplet dispersion and reticulum
Spastin mutations impair coordination between lipid droplet dispersion and reticulum Open
Lipid droplets (LD) are affected in multiple human disorders. These highly dynamic organelles are involved in many cellular roles. While their intracellular dispersion is crucial to ensure their function and other organelles-contact, under…
View article: Ratiometric Imaging Using a Single Dye Enables Simultaneous Visualization of Rac1 and Cdc42 Activation
Ratiometric Imaging Using a Single Dye Enables Simultaneous Visualization of Rac1 and Cdc42 Activation Open
Biosensors that report endogenous protein activity in vivo can be based on environment-sensing fluorescent dyes. The dyes can be attached to reagents that bind selectively to a specific conformation of the targeted protein, such that bindi…
View article: EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity
EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity Open
View article: Ratiometric Imaging Using a Single Dye Enables Simultaneous Visualization of Rac1 and Cdc42 Activation
Ratiometric Imaging Using a Single Dye Enables Simultaneous Visualization of Rac1 and Cdc42 Activation Open
Biosensors that report endogenous protein activity in vivo can be based on environment-sensing fluorescent dyes. The dyes can be attached to reagents that bind selectively to a specific conformation of the targeted protein, such that bindi…