Timothy R. Arnett
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View article: Author Correction: Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments
Author Correction: Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments Open
View article: Extracellular pH is a critical regulator of osteoclast fusion, size and activation
Extracellular pH is a critical regulator of osteoclast fusion, size and activation Open
Osteoclast activity is regulated by extracellular pH, whereby bone resorption is near-maximally activated at pH 7.0 but limited at ≥pH 7.4. This study examined the effects of low pH on osteoclast fusion, multi-nucleation, resorption and ce…
View article: A Machine Learning-Based Image Segmentation Method to Quantify In Vitro Osteoclast Culture Endpoints
A Machine Learning-Based Image Segmentation Method to Quantify In Vitro Osteoclast Culture Endpoints Open
View article: Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts
Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts Open
View article: Editorial: Special issue on purinergic signalling and calcification
Editorial: Special issue on purinergic signalling and calcification Open
View article: Formal verification of Fuzzy-based XAI for Strategic Combat Game
Formal verification of Fuzzy-based XAI for Strategic Combat Game Open
Explainable AI is a topic at the forefront of the field currently for reasons involving human trust in AI, correctness, auditing, knowledge transfer, and regulation. AI that is developed with reinforcement learning (RL) is especially of in…
View article: Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments
Hypoxia mimetics restore bone biomineralisation in hyperglycaemic environments Open
View article: Modulation of osteoblast differentiation and function by the P2X4 receptor
Modulation of osteoblast differentiation and function by the P2X4 receptor Open
Bone cells are known to express multiple P2 receptor subtypes, and the functional effects of receptor activation have been described for many of these. One exception is the P2X4 receptor, which despite strong expression in osteoblasts and …
View article: Bioengineering the ameloblastoma tumour to study its effect on bone nodule formation
Bioengineering the ameloblastoma tumour to study its effect on bone nodule formation Open
View article: Sheep condyle model evaluation of bone marrow cell concentrate combined with a scaffold for repair of large osteochondral defects
Sheep condyle model evaluation of bone marrow cell concentrate combined with a scaffold for repair of large osteochondral defects Open
Aims Minimally manipulated cells, such as autologous bone marrow concentrates (BMC), have been investigated in orthopaedics as both a primary therapeutic and augmentation to existing restoration procedures. However, the efficacy of BMC in …
View article: Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity
Applied mechanical loading to mouse hindlimb acutely increases skeletal perfusion and chronically enhanced vascular porosity Open
Blood supply is essential for osteogenesis, yet its relationship to load-related increases in bone mass is poorly defined. Herein, we aim to investigate the link between load-induced osteogenesis and the blood supply (bone perfusion and va…
View article: Issue Information
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View article: The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis
The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis Open
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View article: Inhibition of vascular smooth muscle cell calcification by ATP analogues
Inhibition of vascular smooth muscle cell calcification by ATP analogues Open
Arterial medial calcification (AMC) has been associated with phenotypic changes in vascular smooth muscle cells (VSMCs) that reportedly makes them more osteoblast-like. Previous work has shown that ATP/UTP can inhibit AMC directly via P2 r…
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View article: Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts
Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts Open
Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, in the medial layer of the arteries. AMC shares some similarities to skeletal mineralisation and has been associated with the tran…
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View article: Influence of pH on osteoclasts treated with zoledronate and alendronate
Influence of pH on osteoclasts treated with zoledronate and alendronate Open
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View article: Micro-computed tomography reconstructions of tibiae of stem cell transplanted osteogenesis imperfecta mice
Micro-computed tomography reconstructions of tibiae of stem cell transplanted osteogenesis imperfecta mice Open
Micro-computed tomography (micro-CT) is commonly used to assess bone quality and to evaluate the outcome of experimental therapies in animal models of bone diseases. Generating large datasets is however challenging and data are rarely made…
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View article: Wild-type3 3D
Wild-type3 3D Open
3D microCT reconstruction of mouse tibiae-wild-type3