Timothy Rockall
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View article: Essential Anatomy for the Abdominal Wall Surgeon: Expert Consensus of Anatomical Concepts and Operative Steps for Posterior Component Separation
Essential Anatomy for the Abdominal Wall Surgeon: Expert Consensus of Anatomical Concepts and Operative Steps for Posterior Component Separation Open
Introduction Abdominal wall surgery is emerging as a new subspecialty with reconstructive operations becoming increasingly complex. Central to any surgical subspecialty is comprehensive anatomical knowledge, which can be enhanced by cadave…
View article: A prospective diagnostic study investigating urinary biomarkers of AKI in major abdominal surgery (the AKI-biomas study)
A prospective diagnostic study investigating urinary biomarkers of AKI in major abdominal surgery (the AKI-biomas study) Open
Background Post-operative acute kidney injury (AKI) is associated with increased morbidity and mortality with evidence suggesting that early identification using biomarkers of AKI may impact prognosis. Most studies in surgical patients has…
View article: The Impact of Prehabilitation on Patient Outcomes in Oesophagogastric Cancer Surgery: Combined Data from Four Prospective Clinical Trials Performed Across the UK and Ireland
The Impact of Prehabilitation on Patient Outcomes in Oesophagogastric Cancer Surgery: Combined Data from Four Prospective Clinical Trials Performed Across the UK and Ireland Open
Background: Prehabilitation is increasingly being used in patients undergoing multimodality treatment for oesophagogastric cancer (OGC). Most studies to date have been small, single-centre trials. This collaborative study sought to assess …
View article: The repeat FIT (RFIT) study: Does repeating faecal immunochemical tests provide reassurance and improve colorectal cancer detection?
The repeat FIT (RFIT) study: Does repeating faecal immunochemical tests provide reassurance and improve colorectal cancer detection? Open
Aim Faecal immunochemical tests (FIT) are highly sensitive for colorectal cancer (CRC) detection. Little evidence exists regarding repeat FIT. The repeat FIT (RFIT) study aimed to determine whether second and third FIT provide reassurance …
View article: The microbial composition of pancreatic ductal adenocarcinoma: a systematic review of 16S rRNA gene sequencing
The microbial composition of pancreatic ductal adenocarcinoma: a systematic review of 16S rRNA gene sequencing Open
Background: Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), continues to pose a significant clinical and scientific challenge. The most significant finding of recent years is that PDAC tumours harbour their specifi…
View article: Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes
Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes Open
Addressing the mononuclear phagocyte system (MPS) and macrophage M1/M2 activation is important in diagnosing hematological disorders and inflammatory pathologies and designing therapeutic tools. CSF1R is a reliable marker to identify all c…
View article: Challenges of dealing with an underperforming or dangerous colleague
Challenges of dealing with an underperforming or dangerous colleague Open
Journal Article Challenges of dealing with an underperforming or dangerous colleague Get access Timothy A Rockall Timothy A Rockall Department of Surgery, Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, UK Corresponde…
View article: O228: Do additional faecal immunochemical tests (FIT) provide more reassurance that colorectal cancer is not being missed? Results from the repeat FIT (RFIT) study
O228: Do additional faecal immunochemical tests (FIT) provide more reassurance that colorectal cancer is not being missed? Results from the repeat FIT (RFIT) study Open
Introduction Faecal immunochemical testing (FIT) is highly sensitive for colorectal cancer (CRC) detection. NICE recommend a single FIT in primary care for urgent cancer referrals. Little evidence regarding the benefit of repeating FIT exi…
View article: Factors affecting quality of life in rectal cancer survivors who have undergone laparoscopic surgery: patient-reported outcomes over 10 years at a single institution
Factors affecting quality of life in rectal cancer survivors who have undergone laparoscopic surgery: patient-reported outcomes over 10 years at a single institution Open
These results compare favourably with the published data. Future studies may benefit from baseline assessment to better assess treatment impact, prescient in an increasingly elderly and comorbid population. This paper establishes that good…
View article: Bile Microbiome Signatures Associated with Pancreatic Ductal Adenocarcinoma Compared to Benign Disease: A UK Pilot Study
Bile Microbiome Signatures Associated with Pancreatic Ductal Adenocarcinoma Compared to Benign Disease: A UK Pilot Study Open
Pancreatic ductal adenocarcinoma (PDAC) has a very poor survival. The intra-tumoural microbiome can influence pancreatic tumourigenesis and chemoresistance and, therefore, patient survival. The role played by bile microbiota in PDAC is unk…
View article: OGC P15 Analysing the Impact of Prehabilitation on Patient Outcomes in Oesophagogastric Cancer Surgery: Combined Data from Four prospective Clinical Trials performed across the UK and Ireland
OGC P15 Analysing the Impact of Prehabilitation on Patient Outcomes in Oesophagogastric Cancer Surgery: Combined Data from Four prospective Clinical Trials performed across the UK and Ireland Open
Background Prehabilitation is increasingly being used in patients undergoing multi-modality treatment for oesophago-gastric (OG) cancer. Most studies to date have been small, single centre trials lacking statistical power. The results of l…
View article: The Role of the Multiparametric MRI LiverMultiScanTM in the Quantitative Assessment of the Liver and Its Predicted Clinical Applications in Patients Undergoing Major Hepatic Resection for Colorectal Liver Metastasis
The Role of the Multiparametric MRI LiverMultiScanTM in the Quantitative Assessment of the Liver and Its Predicted Clinical Applications in Patients Undergoing Major Hepatic Resection for Colorectal Liver Metastasis Open
Liver biopsy remains the gold standard for the histological assessment of the liver. With clear disadvantages and the rise in the incidences of liver disease, the role of neoadjuvant chemotherapy in colorectal liver metastasis (CRLM) and a…
View article: SP3.9 The role of urinary biomarkers in predicting post operative kidney function
SP3.9 The role of urinary biomarkers in predicting post operative kidney function Open
Aims Post-operative Acute Kidney Injury (AKI) has implications on recovery, conferring a significant risk of morbidity and mortality. A previous study of 488 major abdominal surgery patients demonstrated that urinary biomarkers could predi…
View article: SP4.4 A Prospective Diagnostic study investigating Urinary Biomarkers of AKI in Major Abdominal Surgery (The AKI-BioMAS Study)
SP4.4 A Prospective Diagnostic study investigating Urinary Biomarkers of AKI in Major Abdominal Surgery (The AKI-BioMAS Study) Open
Aims To characterize biomarker performance in predicting Acute Kidney Injury (AKI) in Major Abdominal Surgery using both the Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine (AKISCr) and urine output (AKIUO) criteria. Pos…
View article: Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer
Cancer cell-derived extracellular vesicles activate hepatic stellate cells in colorectal cancer Open
Colorectal cancer (CRC) is the 2nd leading cause of cancer-related deaths worldwide, primarily due to the development of metastatic disease. The liver is the most frequently affected site. The metastatic cascade relies on a complex interac…
View article: Systematic review of preoperative n-3 fatty acids in major gastrointestinal surgery
Systematic review of preoperative n-3 fatty acids in major gastrointestinal surgery Open
Objectives Perioperative nutrition aims to replenish nutritional stores before surgery and reduce postoperative complications. ‘Immunonutrition’ (including omega-3 fatty acids) may modulate the immune system and attenuate the postoperative…
View article: The increasing burden of the 2-week wait colorectal cancer pathway in a single centre: the impact of faecal immunochemical tests
The increasing burden of the 2-week wait colorectal cancer pathway in a single centre: the impact of faecal immunochemical tests Open
No significant change in CRC diagnosis was observed, despite increasing TWW referrals. Increasing utilisation of FIT in both primary and secondary care has helped maintain CRC detection while avoiding diagnostic delay. This study supports …
View article: O138 Diagnostic and prognostic factors associated with faecal haemoglobin concentration in a symptomatic cohort
O138 Diagnostic and prognostic factors associated with faecal haemoglobin concentration in a symptomatic cohort Open
Introduction There is limited evidence regarding FIT and colorectal cancer (CRC) site, stage, grade and anaemia in the symptomatic cohort. Primary aim is to determine whether an association exists between FIT (analysed with OC-Sensor™ Pled…
View article: O136 An observational cohort study of replicate faecal immunochemical tests in symptomatic two-week wait patients
O136 An observational cohort study of replicate faecal immunochemical tests in symptomatic two-week wait patients Open
Introduction Triage of patients with suspected colorectal cancer (CRC) utilises a single faecal immunochemical test (FIT) at a defined threshold. Limited evidence exists regarding whether replicate FIT improves the positive and negative pr…
View article: Development of an Enhanced Recovery After Surgery Surgical Safety Checklist Through a Modified Delphi Process
Development of an Enhanced Recovery After Surgery Surgical Safety Checklist Through a Modified Delphi Process Open
Importance Enhanced Recovery After Surgery (ERAS) guidelines and the World Health Organization Surgical Safety Checklist (SSC) are 2 well-established tools for optimizing patient outcomes perioperatively. Objective To integrate the 2 tools…
View article: Protective ileostomy creation after anterior resection of the rectum: Shared decision‐making or still subjective?
Protective ileostomy creation after anterior resection of the rectum: Shared decision‐making or still subjective? Open
Aim The choice of whether to perform protective ileostomy (PI) after anterior resection (AR) is mainly guided by risk factors (RFs) responsible for the development of anastomotic leakage (AL). However, clear guidelines about PI creation ar…
View article: OGC P01 Cost utility analysis of a prehabilitation programme in patients undergoing treatment for oesophageal cancer
OGC P01 Cost utility analysis of a prehabilitation programme in patients undergoing treatment for oesophageal cancer Open
Background Treatment of oesophageal cancer is associated with significant morbidity which has an impact on longer term survival. Prehabilitation has been shown to reduce post-operative morbidity and mortality. The aim of this study was to …
View article: What should be included in case report forms? Development and application of novel methods to inform surgical study design: a mixed methods case study in parastomal hernia prevention
What should be included in case report forms? Development and application of novel methods to inform surgical study design: a mixed methods case study in parastomal hernia prevention Open
Objectives To describe the development and application of methods to optimise the design of case report forms (CRFs) for clinical studies evaluating surgical procedures, illustrated with an example of abdominal stoma formation. Design (1) …
View article: O013 The increasing burden of the two-week wait colorectal cancer pathway within a single centre
O013 The increasing burden of the two-week wait colorectal cancer pathway within a single centre Open
Introduction Increasing demand has placed colorectal cancer (CRC) two-week wait (TWW) pathways under pressure. The primary aims of this paper are to review TWW referral numbers and CRC diagnoses within our centre over the past 3 years (bef…
View article: Patient-reported outcome measures show FIT as an acceptable investigation to rule out colorectal cancer in the two-week wait cohort
Patient-reported outcome measures show FIT as an acceptable investigation to rule out colorectal cancer in the two-week wait cohort Open
Introduction Use of faecal immunochemical testing (FIT) for symptomatic patients is increasing. FIT is recommended as a triage tool from primary care to the two-week wait (TWW) suspected cancer pathway, but there is still little known abou…
View article: A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma
A Comprehensive Review of the Current and Future Role of the Microbiome in Pancreatic Ductal Adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second most common cause of cancer death in the USA by 2030, yet progress continues to lag behind that of other cancers, with only 9% of patients surviving beyond 5 years. L…
View article: Laparoscopic versus open surgery for left flexure colon cancer: A propensity score matched analysis from an international cohort
Laparoscopic versus open surgery for left flexure colon cancer: A propensity score matched analysis from an international cohort Open
Aim Surgical treatment of splenic flexure cancer (SFC) still presents some debated issues, including the role of laparoscopic surgery. The literature is based on small single‐centre series, while randomized controlled studies comparing ope…
View article: Comparison of the QuikRead go<sup>®</sup> point-of-care faecal immunochemical test for haemoglobin with the FOB Gold Wide<sup>®</sup> laboratory analyser to diagnose colorectal cancer in symptomatic patients
Comparison of the QuikRead go<sup>®</sup> point-of-care faecal immunochemical test for haemoglobin with the FOB Gold Wide<sup>®</sup> laboratory analyser to diagnose colorectal cancer in symptomatic patients Open
Objectives Faecal immunochemical testing for haemoglobin (FIT) is used to triage patients for colonic investigations. Point-of-care (POC) FIT devices on the market have limited data for their diagnostic accuracy for colorectal cancer (CRC)…
View article: Systematic Review Comparing the Effectiveness of Robotic verse Laparoscopic Liver Surgery in Colorectal Liver Metastasis (CRLM)
Systematic Review Comparing the Effectiveness of Robotic verse Laparoscopic Liver Surgery in Colorectal Liver Metastasis (CRLM) Open
Introduction: Colorectal cancer (CRC) is the third most common cancer in the world. The liver is the most common site of metastasis with 15 to 25% of patients presenting with synchronous colorectal liver metastasis (CRLM). This study is ai…