Timothy W. Muusse
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View article: TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation
TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation Open
View article: TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages
TLR4 phosphorylation at tyrosine 672 activates the ERK/c‐FOS signaling module for LPS‐induced cytokine responses in macrophages Open
TLRs engage numerous adaptor proteins and signaling molecules, enabling a complex series of post‐translational modifications (PTMs) to mount inflammatory responses. TLRs themselves are post‐translationally modified following ligand‐induced…
View article: Flow cytometric reporter assays provide robust functional analysis of signaling complexes
Flow cytometric reporter assays provide robust functional analysis of signaling complexes Open
Conventional assays to probe signaling protein interactions and function involve measurement of luciferase reporter expression within the bulk cell population, with lack of control over target-protein expression level. To address this issu…
View article: MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography Open
Myeloid differentiation primary response gene 88 (MyD88) and MyD88 adaptor-like/TIRAP (MAL) are Toll-like receptor (TLR) adaptors that signal to induce proinflammatory cytokine production.The TLR responds to a pathogen or endogenous molecu…
View article: MyD88 TIR domain higher-order assembly interactions revealed by serial femtosecond crystallography
MyD88 TIR domain higher-order assembly interactions revealed by serial femtosecond crystallography Open
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production.We previously observed that the TIR domain of MAL (MAL TIR ) forms filaments in vitro and induces formation of crystalline highe…
View article: MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography Open
View article: MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography. Open
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms filaments in vitro and induces formation of crystal…