Timothy Waterhouse
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View article: Population pharmacokinetic modeling of vedolizumab for graft‐versus‐host disease prophylaxis in adults with allogeneic hematopoietic stem cell transplant
Population pharmacokinetic modeling of vedolizumab for graft‐versus‐host disease prophylaxis in adults with allogeneic hematopoietic stem cell transplant Open
We aimed to characterize the population pharmacokinetics (PK) of vedolizumab for acute graft‐versus‐host disease prophylaxis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo‐HSCT) and assess potential clinicall…
View article: Bayesian estimation in <scp>NONMEM</scp>
Bayesian estimation in <span>NONMEM</span> Open
Bayesian estimation is a powerful but underutilized tool for answering drug development questions. In this tutorial, the principles of Bayesian model development, assessment, and prior selection will be outlined. An example pharmacokinetic…
View article: Development of a selective androgen receptor modulator for transdermal use in hypogonadal patients
Development of a selective androgen receptor modulator for transdermal use in hypogonadal patients Open
Summary We have identified a non‐steroidal selective androgen receptor modulator ( SARM ), termed LY 305, that is bioavailable through a transdermal route of administration while highly cleared via hepatic metabolism to limit parent compou…