Timur Tsintsadze
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View article: Direct whole-cell patch-clamp recordings from small boutons in rodent primary neocortical neuron cultures
Direct whole-cell patch-clamp recordings from small boutons in rodent primary neocortical neuron cultures Open
Direct electrical recordings from conventional boutons in the mammalian central nervous system have proven challenging due to their small size. Here, we provide a protocol for direct whole-cell patch-clamp recordings from small presynaptic…
View article: Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons
Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons Open
Summary Endogenous cannabinoid signaling is vital for important brain functions and can be modified pharmacologically to treat pain, epilepsy, and posttraumatic stress disorder. Endocannabinoid mediated changes to excitability are predomin…
View article: Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels
Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels Open
Increasing extracellular [Ca2+] ([Ca2+]o) strongly decreases intrinsic excitability in neurons but the mechanism is unclear. By one hypothesis, [Ca2+]o screens surface charge, reducing voltage-gated sodium channel (VGSC) activation and by …
View article: CaSR modulates sodium channel-mediated Ca<sup>2+</sup>-dependent excitability
CaSR modulates sodium channel-mediated Ca<sup>2+</sup>-dependent excitability Open
Increasing extracellular [Ca 2+ ] ([Ca 2+ ] o ) strongly decreases intrinsic excitability in neurons but the mechanism is unclear. By one hypothesis, [Ca 2+ ] o screens surface charge reducing voltage-dependent sodium channel (VGSC) activa…
View article: Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons
Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons Open
Presynaptic action potential spikes control neurotransmitter release and thus interneuronal communication. However, the properties and the dynamics of presynaptic spikes in the neocortex remain enigmatic because boutons in the neocortex ar…
View article: Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons
Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons Open
SUMMARY Presynaptic action potential spikes control neurotransmitter release and thus interneuronal communication. However, the properties and the dynamics of presynaptic spikes in the neocortex remain enigmatic because boutons in the neoc…
View article: Distinct Actions of Voltage-Activated Ca<sup>2+</sup>Channel Block on Spontaneous Release at Excitatory and Inhibitory Central Synapses
Distinct Actions of Voltage-Activated Ca<sup>2+</sup>Channel Block on Spontaneous Release at Excitatory and Inhibitory Central Synapses Open
At chemical synapses, voltage-activated calcium channels (VACCs) mediate Ca 2+ influx to trigger action potential-evoked neurotransmitter release. However, the mechanisms by which Ca 2+ regulates spontaneous transmission have not been full…