Tina Karagyozova
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View article: HIRA defines early replication initiation zones independently of their genome compartment
HIRA defines early replication initiation zones independently of their genome compartment Open
View article: H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells
H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells Open
View article: HIRA defines early replication initiation zones independently of their genome compartment
HIRA defines early replication initiation zones independently of their genome compartment Open
Chromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells. While they do often correlate, their functional interconnections remain a puzzle. Here, we dissect these relati…
View article: HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation
HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation Open
The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding within the cell nucleus with spatially segregated active and repressed compartments, termed A and B. However, how nucleosome deposition impacts these l…
View article: Replicating chromatin in the nucleus: A histone variant perspective
Replicating chromatin in the nucleus: A histone variant perspective Open
In eukaryotes, chromatin and DNA replication are intimately linked, whereby chromatin impacts DNA replication control while genome duplication involves recovery of chromatin organisation. Here, we review recent advances in this area using …
View article: H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells
H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells Open
Chromocenters in mouse cells are membrane-less nuclear compartments that represent typical heterochromatin stably maintained during the cell cycle. Here, we explore how histone H3 variants, replicative H3.1/H3.2 or replacement H3.3, mark t…
View article: The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport
The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport Open
Single nucelotide polymorphisms (SNPs) at the FAM13A locus are among the most commonly reported risk alleles associated with chronic obstructive pulmonary disease (COPD) and other respiratory diseases; however, the physiological rol…
View article: Spatio-temporal organisation of histone variants : from nucleosomes to nuclei
Spatio-temporal organisation of histone variants : from nucleosomes to nuclei Open
View article: Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air–liquid interface
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air–liquid interface Open
To the Editor:
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\nThe structure and composition of the bronchial epithelium is altered in respiratory diseases such as COPD and asthma, in which goblet cell hyperplasia and reduced numbers of ciliated cells impair mucociliary clearance. …
View article: Highly efficient genome editing in primary bronchial epithelial cells establishes FOXJ1 as essential for ciliation in human airways
Highly efficient genome editing in primary bronchial epithelial cells establishes FOXJ1 as essential for ciliation in human airways Open
The structure and composition of the bronchial epithelium is altered in respiratory diseases such as COPD and asthma, in which goblet cell hyperplasia and reduced numbers of ciliated cells impair mucociliary clearance. We describe a robust…