Tina Okdahl
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View article: Protocol for the FibroCAN study: a randomised controlled trial of finerenone treatment for early-stage cardiovascular autonomic neuropathy in type 2 diabetes
Protocol for the FibroCAN study: a randomised controlled trial of finerenone treatment for early-stage cardiovascular autonomic neuropathy in type 2 diabetes Open
Introduction Cardiovascular autonomic neuropathy (CAN) is a serious, untreatable complication of diabetes that contributes to excess cardiovascular mortality and morbidity. CAN is associated with increased fibrosis and inflammation, possib…
View article: Current advances in diabetic neuropathy: Proteins as therapeutic targets
Current advances in diabetic neuropathy: Proteins as therapeutic targets Open
Diabetic neuropathy is a debilitating complication of diabetes characterized by nerve damage that may lead to numbness, foot ulcers, and amputations, and is a major cause of morbidity and mortality in people with diabetes. There are no tre…
View article: Panenteric Transit Times and Contractile Activity in Diabetic Gastroenteropathy
Panenteric Transit Times and Contractile Activity in Diabetic Gastroenteropathy Open
Gastrointestinal transit times, as well as antral and colonic contractile activity, differed between individuals with diabetic gastroenteropathy and controls. The overall gastric contraction frequency was associated with symptom severity.
View article: Diabetic gastroenteropathy: Associations between gastrointestinal symptoms, motility, and extraintestinal autonomic measures
Diabetic gastroenteropathy: Associations between gastrointestinal symptoms, motility, and extraintestinal autonomic measures Open
Background Diabetic gastroenteropathy can cause significant diagnostic challenges. Still, it remains unknown if measures of extraintestinal autonomic function reflect diabetic gastroenteropathy. We aimed to assess the associations between …
View article: Effects of opium tincture on gastrointestinal function and motility in healthy volunteers: A magnetic resonance imaging study
Effects of opium tincture on gastrointestinal function and motility in healthy volunteers: A magnetic resonance imaging study Open
Background Opioids inhibit motility and secretion of the gut and have been used for antidiarrheal treatment for centuries. However, the underlying mechanisms of opium tincture are not evident. Aim To investigate the effects of opium tinctu…
View article: Transcutaneous vagus nerve stimulation has no anti-inflammatory effect in diabetes
Transcutaneous vagus nerve stimulation has no anti-inflammatory effect in diabetes Open
Chronic inflammation is associated with diabetes and contributes to the development and progression of micro- and macrovascular complications. Transcutaneous vagus nerve stimulation (tVNS) has been proposed to reduce levels of circulating …
View article: The influence of tramadol on bowel function: A randomised, placebo‐controlled trial
The influence of tramadol on bowel function: A randomised, placebo‐controlled trial Open
Tramadol is a weak opioid used to treat moderate pain. Stronger opioids inhibit gastrointestinal function, but little is known about the gastrointestinal effects of tramadol. Our aim was to investigate if tramadol causes opioid‐induced bow…
View article: Opium tincture has anti-propulsive effects in patients with chronic diarrhea: a randomized, placebo-controlled, and cross-over trial
Opium tincture has anti-propulsive effects in patients with chronic diarrhea: a randomized, placebo-controlled, and cross-over trial Open
Opium tincture induced anti-propulsive effects in patients with chronic diarrhea refractory to standard treatment. This indicates that opium tincture is a relevant treatment strategy for selected patients with chronic diarrhea. Moreover, n…
View article: Recommendations for the management of opioid-induced constipation - how to improve usability in clinical practice
Recommendations for the management of opioid-induced constipation - how to improve usability in clinical practice Open
Despite standard treatment with laxatives and fluid intake in patients with opioid-induced constipation, escalation of treatment is often needed where μ-opioid receptor antagonists or newer medications such as lubiprostone, linaclotide, or…
View article: MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms
MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms Open
Background: Diabetes-induced gastrointestinal (GI) symptoms are common but difficult to correctly diagnose and manage. We used multi-segmental magnetic resonance imaging (MRI) to evaluate structural and functional GI parameters in diabetic…
View article: Features characterising cardiac autonomic neuropathy in diabetes using ensembled classification
Features characterising cardiac autonomic neuropathy in diabetes using ensembled classification Open
Cardiac reflex responses should be monitored closely to diagnose and classify severity levels of CAN accurately. Standard clinical biochemical analytes, such as glycaemic level, lipidic level, or kidney function were not included in the te…
View article: Systemic Cytokine Expression in Diabetes Is Associated with Prolonged Gastrointestinal Transit Times and Cardinal Gastroparesis Symptoms
Systemic Cytokine Expression in Diabetes Is Associated with Prolonged Gastrointestinal Transit Times and Cardinal Gastroparesis Symptoms Open
Gastroenteropathy is a common complication in diabetes associated with damages to the enteric nervous system. Systemic low-grade inflammation facilitates neurotoxicity, and associations with peripheral and autonomic neuropathy have been re…
View article: Opioids in the Treatment of Chronic Idiopathic Diarrhea in Humans—A Systematic Review and Treatment Guideline
Opioids in the Treatment of Chronic Idiopathic Diarrhea in Humans—A Systematic Review and Treatment Guideline Open
In patients with chronic idiopathic diarrhea resistant to standard treatment, opioids are often used as rescue therapy. This systematic review investigated opioid effects on gut function in chronic diarrhea. PubMed and Embase were searched…
View article: Effects of opium tincture on the enteric and central nervous systems: A randomized controlled trial
Effects of opium tincture on the enteric and central nervous systems: A randomized controlled trial Open
Opioids change gut motility, and opium tincture has been used for treatment of chronic diarrhoea for centuries. However, the effects have never been documented in controlled trials. We aimed to investigate the effects of opium tincture on …
View article: Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic
Low-grade inflammation in type 2 diabetes: a cross-sectional study from a Danish diabetes outpatient clinic Open
Objectives To investigate low-grade inflammation in type 2 diabetes and explore associations to clinical aspects as well as microvascular and macrovascular complications. Design Cross-sectional analysis. Setting The outpatient diabetes cli…
View article: Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes
Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes Open
Background Systemic inflammatory processes plausibly contribute to the development of cardiovascular complications, causing increased morbidity and mortality in type 2 diabetes. Circulating inflammatory markers, i.e., interleukin (IL)-6 an…
View article: Study protocol for a multicentre, randomised, parallel group, sham-controlled clinical trial investigating the effect of transcutaneous vagal nerve stimulation on gastrointestinal symptoms in people with diabetes complicated with diabetic autonomic neuropathy: the DAN-VNS Study
Study protocol for a multicentre, randomised, parallel group, sham-controlled clinical trial investigating the effect of transcutaneous vagal nerve stimulation on gastrointestinal symptoms in people with diabetes complicated with diabetic autonomic neuropathy: the DAN-VNS Study Open
Introduction A high proportion of people with diabetes experience gastrointestinal (GI) symptoms, which may be manifestations of diabetic autonomic neuropathy (DAN). The current treatment regime is ineffective and associated with major sid…
View article: Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes
Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes Open
Introduction . A neuroimmune communication exists, and compelling evidence suggests that diabetic neuropathy and systemic inflammation are linked. Our aims were (1) to investigate biomarkers of the ongoing inflammation processes including …
View article: Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes
Increased levels of inflammatory factors are associated with severity of polyneuropathy in type 1 diabetes Open
Objective Distal symmetrical polyneuropathy (DSPN) is a severe common long‐term complication of type 1 diabetes caused by impaired sensory‐motor nerve function. As chronic low‐grade inflammation may be involved in the pathogenesis of DSPN,…
View article: Circulating Inflammatory Markers are Inversely Associated with Heart Rate Variability Measures in type 1 Diabetes
Circulating Inflammatory Markers are Inversely Associated with Heart Rate Variability Measures in type 1 Diabetes Open
Background A neuro-immune communication exists, and compiling evidence suggests that diabetic neuropathy and systemic inflammation are linked. Our aims were 1) to investigate biomarkers of the ongoing inflammation processes including cytok…