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View article: Statin use for primary prevention of cardiovascular disease reduces the risk of incident IBD: A population‐based cohort study
Statin use for primary prevention of cardiovascular disease reduces the risk of incident IBD: A population‐based cohort study Open
Background and objectives Beyond genetics, environmental factors may contribute to the rising incidence of inflammatory bowel disease (IBD). Statins, widely used for cardiovascular risk reduction, also have anti‐inflammatory properties and…
View article: Inflammatory Bowel Disease and Risk of More than 1,500 Comorbidities: A Disease-wide Prediagnostic and Postdiagnostic Phenomic Association Study
Inflammatory Bowel Disease and Risk of More than 1,500 Comorbidities: A Disease-wide Prediagnostic and Postdiagnostic Phenomic Association Study Open
INTRODUCTION: Inflammatory bowel disease (IBD) is associated with various extraintestinal manifestations. We aimed to identify comorbidities in IBD and the timing of their development to provide potentially useful insight into the associat…
View article: Temporal trends in surgical treatment of inflammatory bowel disease following introduction of biological drugs in Norway and Sweden
Temporal trends in surgical treatment of inflammatory bowel disease following introduction of biological drugs in Norway and Sweden Open
Objective The advent of biological drugs has revolutionised management of inflammatory bowel disease (IBD). However, the extent to which these novel pharmacological drugs have reduced the need for surgical treatment remains incompletely qu…
View article: Identifying Critical Phases for Disease Onset with Sparse Haematological Biomarkers
Identifying Critical Phases for Disease Onset with Sparse Haematological Biomarkers Open
Routinely collected clinical blood tests are an emerging molecular data source for large-scale biomedical research but inherently feature irregular sampling and informative observation. Traditional approaches rely on imputation, which can …
View article: Anthropometric Trajectories in Children Prior to Development of Inflammatory Bowel Disease
Anthropometric Trajectories in Children Prior to Development of Inflammatory Bowel Disease Open
Importance Poor nutrition and growth in childhood have short-term and long-term consequences, so understanding the timing of the onset of an impaired nutritional status is crucial for diagnosing and treating inflammatory bowel disease (IBD…
View article: P1199 Early life exposures predict childhood-onset IBD in a population-based cohort
P1199 Early life exposures predict childhood-onset IBD in a population-based cohort Open
Background While many early life exposures have been associated with IBD, prediction of risk based on these variables is not yet available. Therefore, we developed and validated a prediction model for IBD based on early life exposures. Met…
View article: OP32 Identifying clusters of antibiotic use patterns after the first episode of pouchitis in a population-based cohort
OP32 Identifying clusters of antibiotic use patterns after the first episode of pouchitis in a population-based cohort Open
Background An estimated 17% of patients will develop chronic pouchitis after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), however little is known about antibiotic prescribing patterns in the immediate period after an in…
View article: P1210 Risk of post-acute sequalae of COVID-19 in patients with immune-mediated inflammatory diseases
P1210 Risk of post-acute sequalae of COVID-19 in patients with immune-mediated inflammatory diseases Open
Background Evidence suggest that about 10-30% of individuals with COVID-19 develop a chronic condition following the acute phase, now referred to as the post-acute sequalae of COVID-19 (PASC) or long COVID1,2. Dysregulation of the immune s…
View article: P1204 Childhood EBV infection is protective against IBD, while adulthood EBV infection is not: a population-based cohort study
P1204 Childhood EBV infection is protective against IBD, while adulthood EBV infection is not: a population-based cohort study Open
Background Emerging data indicate a role of Epstein Barr Virus (EBV) infection in immune-mediated diseases risk. However, its role in inflammatory bowel disease (IBD) risk remains to be elucidated. Methods We conducted a nationwide populat…
View article: P1201 Pre- and postnatal metal exposures impact Crohn’s Disease risk and intestinal inflammation in an analysis of deciduous teeth
P1201 Pre- and postnatal metal exposures impact Crohn’s Disease risk and intestinal inflammation in an analysis of deciduous teeth Open
Background Early-life exposures influence long-term health, including the risk of IBD, however measuring these exposures is challenging. A prior pilot study showed that deciduous teeth could quantify environmental exposures. Here we analyz…
View article: P1259 A 15-year analysis of Inflammatory Bowel Disease in Africa using Google Trends
P1259 A 15-year analysis of Inflammatory Bowel Disease in Africa using Google Trends Open
Background Currently, much of Africa’s inflammatory bowel disease (IBD) epidemiology status is unknown.1 While a few observational studies suggest a rise in incidence, alternative methods are necessary to gather widespread data on IBD unti…
View article: P0713 Feasibility of a Physical Activity intervention in Patients with IBD - the PASIBO Study
P0713 Feasibility of a Physical Activity intervention in Patients with IBD - the PASIBO Study Open
Background Recent studies suggest that physical activity (PA) may improve the quality of life and relieve fatigue in patients with inflammatory bowel disease (IBD). However, there is no consensus as to what type of PA intervention should b…
View article: P1198 Statin Use for Primary Prevention of Cardiovascular Disease and its Association with Risk of Incident Inflammatory Bowel Disease: A Population-Based Cohort Study
P1198 Statin Use for Primary Prevention of Cardiovascular Disease and its Association with Risk of Incident Inflammatory Bowel Disease: A Population-Based Cohort Study Open
Background Environmental factors, which play a critical role in the rising incidence of inflammatory bowel disease (IBD), may hold the key for prevention. Statins, known for their cardiovascular benefits, possess anti-inflammatory properti…
View article: OP19 Pre- and Post-diagnostic Metabolomic Biomarker Profiling of Over 700,000 Individuals in Three National Biobanks Enables Prediction of Inflammatory Bowel Disease Onset and Complications
OP19 Pre- and Post-diagnostic Metabolomic Biomarker Profiling of Over 700,000 Individuals in Three National Biobanks Enables Prediction of Inflammatory Bowel Disease Onset and Complications Open
Background We currently lack sensitive and specific prognostic biomarkers of inflammatory bowel disease (IBD) onset and severity. In three large, population-scale cohorts, we investigated metabolomic biomarkers for predicting disease onset…
View article: P0252 Mild Crohn’s disease is associated with altered sphingolipid metabolism and reduced neutrophilic inflammation
P0252 Mild Crohn’s disease is associated with altered sphingolipid metabolism and reduced neutrophilic inflammation Open
Background Around 20-30% of patients with Crohn's disease (CD) experience a mild disease course. However, identifying patients likely to maintain a mild course is challenging. This study aimed to identify molecular features of mild CD by e…
View article: Prevalence and Prognosis of Mild Inflammatory Bowel Disease: A Population-based Cohort Study, 1997–2020
Prevalence and Prognosis of Mild Inflammatory Bowel Disease: A Population-based Cohort Study, 1997–2020 Open
Approximately one-fourth of individuals with mild UC within 1 year after diagnosis and one-half of those with mild CD progressed to moderate-severe disease over time. Young age at diagnosis increased the probability of progression, whereas…
View article: Genetic risk of inflammatory bowel disease is associated with disease course severity
Genetic risk of inflammatory bowel disease is associated with disease course severity Open
Background and aims Genetic susceptibility to inflammatory bowel disease (IBD) has been widely studied, whereas the genetic contribution to disease progression over time remains relatively under-investigated. In a Danish nationwide cohort,…
View article: A Systematic Review and Meta-Analysis: Adverse Inflammatory Bowel Disease Outcomes Following Acute COVID-19
A Systematic Review and Meta-Analysis: Adverse Inflammatory Bowel Disease Outcomes Following Acute COVID-19 Open
In this systematic review and meta-analysis, we find that COVID-19 did not increase the risk of adverse IBD outcomes.
View article: Comprehensive phage display viral antibody profiling using VirScan: potential applications in chronic immune-mediated disease
Comprehensive phage display viral antibody profiling using VirScan: potential applications in chronic immune-mediated disease Open
Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensi…
View article: HLA-DRB1*01:03 and Severe Ulcerative Colitis
HLA-DRB1*01:03 and Severe Ulcerative Colitis Open
This Danish nationwide genome-wide association study aims to identify biomarkers of severe vs less severe ulcerative colitis.
View article: A 15-Year Analysis of Inflammatory Bowel Disease in Africa Using Google Trends
A 15-Year Analysis of Inflammatory Bowel Disease in Africa Using Google Trends Open
Background There is little to no evidence on the status of inflammatory bowel disease (IBD) in Africa. Due to a lack of epidemiological data for the disease on the continent, alternative methods are necessary to gather information data on …
View article: Inflammatory Markers at Birth and Risk of Early-Onset Inflammatory Bowel Disease
Inflammatory Markers at Birth and Risk of Early-Onset Inflammatory Bowel Disease Open
The development of inflammatory bowel disease (IBD) may be preceded by a long preclinical phase characterized by several disease-associated immunologic changes, as observed for other immune-mediated inflammatory diseases.1Rudbaek J.J. et a…
View article: Vitamin D regulates microbiome-dependent cancer immunity
Vitamin D regulates microbiome-dependent cancer immunity Open
A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented resp…
View article: Risk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study
Risk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study Open
Objective Bile acid diarrhoea is a common cause of chronic diarrhoea. Increased levels of potentially carcinogenic bile acids in faeces, theoretically, may increase the risk of colorectal cancer in particular, but the long-term disease cou…