Tine Sylvest Meyhoff
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View article: Sex-based differences in ICU management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort
Sex-based differences in ICU management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort Open
View article: Adaptations and Heterogeneity of Treatment Effects in Platform Trials—Protocol for Two Methodological Studies
Adaptations and Heterogeneity of Treatment Effects in Platform Trials—Protocol for Two Methodological Studies Open
Background Adaptive platform trials bring opportunities for improved infrastructure and effective advancement in medical care but are methodologically complex. Assessment of heterogeneity of treatment effects (HTE) according to participant…
View article: <scp>INCEPT</scp>: The Intensive Care Platform Trial—Design and protocol
<span>INCEPT</span>: The Intensive Care Platform Trial—Design and protocol Open
Background Adult intensive care unit (ICU) patients receive many interventions, but few are supported by high‐certainty evidence. Randomised clinical trials (RCTs) are essential for trustworthy comparisons of intervention effects, but conv…
View article: Preferences for thromboprophylaxis in the intensive care unit: An international survey
Preferences for thromboprophylaxis in the intensive care unit: An international survey Open
Background Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis is widely applied to lower this risk, but guidelines lack dosing recomm…
View article: Preferences for albumin use in adult intensive care unit patients with shock: An international survey
Preferences for albumin use in adult intensive care unit patients with shock: An international survey Open
Introduction Use of albumin is suggested for some patients with shock, but preferences for its use may vary among intensive care unit (ICU) physicians. Methods We conducted an international online survey of ICU physicians with 20 questions…
View article: Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial
Effects of restrictive fluid therapy on the time to resolution of hyperlactatemia in ICU patients with septic shock. A secondary post hoc analysis of the CLASSIC randomized trial Open
In this post hoc retrospective analysis of a multicenter randomized controlled trial (RCT), a restrictive intravenous fluid strategy did not seem to affect the time to resolution of hyperlactatemia in adult ICU patients with septic shock.
View article: Conservative Versus Liberal Fluid Resuscitation for Septic Patients at Risk for Fluid Overload: A Systematic Review with Meta-Analysis
Conservative Versus Liberal Fluid Resuscitation for Septic Patients at Risk for Fluid Overload: A Systematic Review with Meta-Analysis Open
View article: Heterogeneity of treatment effect of higher dose dexamethasone by geographic region (Europe vs. India) in patients with COVID-19 and severe hypoxemia – a post hoc evaluation of the COVID STEROID 2 trial
Heterogeneity of treatment effect of higher dose dexamethasone by geographic region (Europe vs. India) in patients with COVID-19 and severe hypoxemia – a post hoc evaluation of the COVID STEROID 2 trial Open
None for this analysis. The COVID STEROID 2 trial was funded by The Novo Nordisk Foundation and supported by Rigshospitalet's Research Council.
View article: Perioperative glucocorticoid stress dose for adult surgical patients at risk of adrenal insufficiency
Perioperative glucocorticoid stress dose for adult surgical patients at risk of adrenal insufficiency Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the effect and harms of perioperative glucocorticoid stress dose for patients with known or suspected adrenal insufficiency for prevention …
View article: Albumin administration in septic shock—Protocol for post‐hoc analyses of data from a multicentre <scp>RCT</scp>
Albumin administration in septic shock—Protocol for post‐hoc analyses of data from a multicentre <span>RCT</span> Open
Background Intravenous (IV) albumin is suggested for patients with septic shock who have received large amounts of IV crystalloids; a conditional recommendation based on moderate certainty of evidence. Clinical variation in the administrat…
View article: Lower vs Higher Fluid Volumes in Adult Patients With Sepsis
Lower vs Higher Fluid Volumes in Adult Patients With Sepsis Open
View article: Protocol for a systematic review and meta-analysis assessing conservative versus liberal intravenous fluid administration in patients with sepsis or septic shock at risk of fluid overload
Protocol for a systematic review and meta-analysis assessing conservative versus liberal intravenous fluid administration in patients with sepsis or septic shock at risk of fluid overload Open
Introduction Intravenous crystalloid fluid resuscitation forms a crucial part of the early intervention bundle for sepsis and septic shock, with the Surviving Sepsis Campaign guidelines recommending a 30 mL/kg fluid bolus within the first …
View article: Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock Open
Purpose To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy…
View article: Editorial: Fluid overload in the critically ill
Editorial: Fluid overload in the critically ill Open
EDITORIAL article Front. Med., 03 March 2023Sec. Intensive Care Medicine and Anesthesiology Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1166202
View article: Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial Open
View article: Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial Open
IMPORTANCE Dexamethasone 6 mg daily is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those with more severe disease. OBJECTIVE To assess the effects of dexamethasone 12 mg versus…
View article: Higher vs Lower Doses of Dexamethasone in Patients with COVID‐19 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysis
Higher vs Lower Doses of Dexamethasone in Patients with COVID‐19 and Severe Hypoxia (COVID STEROID 2) trial: Protocol for a secondary Bayesian analysis Open
Background Coronavirus disease 2019 (COVID‐19) can lead to severe hypoxic respiratory failure and death. Corticosteroids decrease mortality in severely or critically ill patients with COVID‐19. However, the optimal dose remains unresolved.…
View article: A new tool to assess Clinical Diversity In Meta‐analyses (CDIM) of interventions
A new tool to assess Clinical Diversity In Meta‐analyses (CDIM) of interventions Open
CDIM is the first tool developed for assessing clinical diversity in meta-analyses of interventions. We found CDIM to be a reliable tool for assessing clinical diversity among trials in meta-analysis.
View article: Dexamethasone 12 mg Versus 6 mg for Patients With COVID-19 and Severe Hypoxia: An International, Randomised, Blinded Trial
Dexamethasone 12 mg Versus 6 mg for Patients With COVID-19 and Severe Hypoxia: An International, Randomised, Blinded Trial Open
View article: Fluid trials: searching for a solution to an age-old problem
Fluid trials: searching for a solution to an age-old problem Open
View article: Response
Response Open
View article: Respiratory Mechanics and Outcomes in Immunocompromised Patients With ARDS
Respiratory Mechanics and Outcomes in Immunocompromised Patients With ARDS Open
View article: Long‐term patient‐important outcomes after septic shock: A protocol for 1‐year follow‐up of the CLASSIC trial
Long‐term patient‐important outcomes after septic shock: A protocol for 1‐year follow‐up of the CLASSIC trial Open
Background In patients with septic shock, mortality is high, and survivors experience long‐term physical, mental and social impairments. The ongoing Conservative vs Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASS…
View article: Time to onset of gastrointestinal bleeding in the SUP‐ICU trial: A pre‐planned substudy
Time to onset of gastrointestinal bleeding in the SUP‐ICU trial: A pre‐planned substudy Open
Background The aetiology and risk factors for clinically important gastrointestinal bleeding (CIB) in adult ICU patients may differ according to the onset of CIB, which could affect the balance between benefits and harms of stress ulcer pr…
View article: Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial—Protocol and statistical analysis plan
Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial—Protocol and statistical analysis plan Open
Introduction Intravenous (IV) fluid is a key intervention in the management of septic shock. The benefits and harms of lower versus higher fluid volumes are unknown and thus clinical equipoise exists. We describe the protocol and detailed …
View article: Therapeutic bronchoscopy vs. standard of care in acute respiratory failure: a systematic review
Therapeutic bronchoscopy vs. standard of care in acute respiratory failure: a systematic review Open
Background We aimed to assess patient‐important benefits and harms of therapeutic bronchoscopy vs. standard of care (no bronchoscopy) in critically ill patients with acute respiratory failure ( ARF ). Methods We conducted a systematic revi…
View article: Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study
Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study Open