Da‐Ting Lin
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View article: Patchy striatonigral neurons modulate locomotor vigor in response to environmental valence
Patchy striatonigral neurons modulate locomotor vigor in response to environmental valence Open
Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles in locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral and indirect-pathway striatopallidal neurons, can be fur…
View article: Distinct prelimbic cortex ensembles encode response execution and inhibition
Distinct prelimbic cortex ensembles encode response execution and inhibition Open
Learning when to initiate or withhold actions is essential for survival, requiring the integration of past experiences with new information to adapt to changing environments. The prelimbic cortex (PL) plays a central role in this process, …
View article: Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Demenia-like deficits
Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Demenia-like deficits Open
TDP-43 dysfunction is an early pathogenic determinant of frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), a devastating disorder currently without effective therapy. Here, we exploit a blood-brain-barrier (BBB)-permeable…
View article: Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence
Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence Open
Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles in locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral and indirect-pathway striatopallidal neurons, can be fur…
View article: Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration
Using miniscopes and deep learning to compare neurobehavioral representations of psychostimulant and opioid self-administration Open
Concurrent abuse of psychostimulants and opioids represents a growing public health concern. However, preclinical models of substance use disorder often situate psychostimulants and opioids similarly within a unified self-administration pr…
View article: Drug self-administration, drug-specific behaviors, and neurobehavioral deep learning analyses
Drug self-administration, drug-specific behaviors, and neurobehavioral deep learning analyses Open
Pharmacokinetic-pharmacodynamics (PKPD) models have been applied to determine real-time drug concentration while in vivo imaging techniques capture real-time behavioral and neural dynamics in preclinical models. Integration of PKPD models …
View article: Protocol for recording neuronal activity in food and cocaine self-administration in freely behaving mice using calcium imaging
Protocol for recording neuronal activity in food and cocaine self-administration in freely behaving mice using calcium imaging Open
In vivo calcium imaging has revealed complex neural activity during operant conditioning. Here, we present a protocol for large-scale, long-term recording of neural activity in freely behaving mice using viral injection, gradient lens impl…
View article: Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence
Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence Open
Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles in locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral and indirect-pathway striatopallidal neurons, can be fur…
View article: Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence
Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence Open
Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles in locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral and indirect-pathway striatopallidal neurons, can be fur…
View article: Patchy striatonigral neurons modulate locomotor vigor in response to environmental valence
Patchy striatonigral neurons modulate locomotor vigor in response to environmental valence Open
Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles in locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral and indirect-pathway striatopallidal neurons, can be fur…
View article: Cell-type specific epigenetic and transcriptional mechanisms in substance use disorder
Cell-type specific epigenetic and transcriptional mechanisms in substance use disorder Open
Substance use disorder (SUD) is a chronic and relapse-prone neuropsychiatric disease characterized by impaired brain circuitry within multiple cell types and neural circuits. Recent advancements in single-cell transcriptomics, epigenetics,…
View article: Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence
Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence Open
Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles in locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral and indirect-pathway striatopallidal neurons, can be fur…
View article: Distinct prelimbic cortex ensembles encode response execution and inhibition
Distinct prelimbic cortex ensembles encode response execution and inhibition Open
Learning when to initiate or withhold actions is essential for survival and requires integration of past experiences with new information to adapt to changing environments. While stable prelimbic cortex (PL) ensembles have been identified …
View article: Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods
Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods Open
In vivo calcium imaging in freely moving rats using miniscopes provides valuable information about the neural mechanisms of behavior in real time. A gradient index (GRIN) lens can be implanted in deep brain structures to relay activity fro…
View article: Imaging distinct neuronal populations with a dual channel miniscope
Imaging distinct neuronal populations with a dual channel miniscope Open
Miniature fluorescence microscopes (miniscopes) are one of the most powerful and versatile tools for recording large scale neural activity in freely moving rodents with single cell resolution. Recent advances in the design of genetically e…
View article: Individual differences in prelimbic neural representation of food and cocaine seeking
Individual differences in prelimbic neural representation of food and cocaine seeking Open
The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observ…
View article: Minibox: Custom solo or semi-group housing chambers for long term housing of rats with miniscopes
Minibox: Custom solo or semi-group housing chambers for long term housing of rats with miniscopes Open
In this detailed procedure, we include open-source methodologies using 'solidworks' designs for creating solo or semi-group housing units for rats wearing miniscopes for long periods of time. Builds are optimized to preserve rat health and…
View article: A modular, cost-effective, versatile, open-source operant box solution for long-term miniscope imaging, 3D tracking, and deep learning behavioral analysis
A modular, cost-effective, versatile, open-source operant box solution for long-term miniscope imaging, 3D tracking, and deep learning behavioral analysis Open
In this procedure we have included an open-source method for a customized operant chamber optimized for long-term miniature microscope (miniscope) recordings. •The miniscope box is designed to function with custom or typical med-associates…
View article: Examining a punishment-related brain circuit with miniature fluorescence microscopes and deep learning
Examining a punishment-related brain circuit with miniature fluorescence microscopes and deep learning Open
In humans experiencing substance use disorder (SUD), abstinence from drug use is often motivated by a desire to avoid some undesirable consequence of further use: health effects, legal ramifications, etc. This process can be experimentally…
View article: Jump-GRS: a multi-phase approach to structured pruning of neural networks for neural decoding
Jump-GRS: a multi-phase approach to structured pruning of neural networks for neural decoding Open
Objective. Neural decoding, an important area of neural engineering, helps to link neural activity to behavior. Deep neural networks (DNNs), which are becoming increasingly popular in many application fields of machine learning, show promi…
View article: GRIN lens applications for studying neurobiology of substance use disorder
GRIN lens applications for studying neurobiology of substance use disorder Open
Substance use disorder (SUD) is associated with severe health and social consequences. Continued drug use results in alterations of circuits within the mesolimbic dopamine system. It is critical to observe longitudinal impacts of SUD on ne…