Ting-Hao Kuo
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View article: Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in <i>Clostridioides difficile</i>
Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in <i>Clostridioides difficile</i> Open
Clostridioides difficile infection can cause severe inflammation in the gastrointestinal (GI) tract, leading to diarrhea, colitis, and an increased risk of colorectal cancer. Colonization of C. difficile is associated with microbial commun…
View article: Early Prediction of Septic Shock in Emergency Department Using Serum Metabolites
Early Prediction of Septic Shock in Emergency Department Using Serum Metabolites Open
Early recognition of septic shock is crucial for improving clinical management and patient outcomes, especially in the emergency department (ED). This study conducted serum metabolomic profiling on ED patients diagnosed with septic shock (…
View article: Mapping Lipid C═C Isomer Profiles of Human Gut Bacteria through a Novel Structural Lipidomics Workflow Assisted by Chemical Epoxidation
Mapping Lipid C═C Isomer Profiles of Human Gut Bacteria through a Novel Structural Lipidomics Workflow Assisted by Chemical Epoxidation Open
The unsaturated lipids produced by human gut bacteria have an extraordinary range of structural diversity, largely because of the isomerism of the carbon-carbon double bond (C═C) in terms of its position and stereochemistry. Characterizing…
View article: Mapping lipid C=C isomer profiles of human gut bacteria by a novel structural lipidomics workflow assisted by chemical epoxidation
Mapping lipid C=C isomer profiles of human gut bacteria by a novel structural lipidomics workflow assisted by chemical epoxidation Open
The unsaturated lipids produced by human gut bacteria exhibit extraordinary structural diversity, largely attributed to the isomerism of the carbon-carbon double bond (C=C) in terms of position and stereochemistry. Characterizing these dis…
View article: Clinical and Genotypic Insights Into Higher Prevalence of Palbociclib Associated Neutropenia in Asian Patients
Clinical and Genotypic Insights Into Higher Prevalence of Palbociclib Associated Neutropenia in Asian Patients Open
Background CDK4/6 inhibitors (CDK4/6i) have shown great efficacy in prolonging progression-free survival and is the current standard of care for hormone positive (HR(+)) metastatic breast cancer (mBC). Despite well tolerability and ease of…
View article: Metabolomics Characterization of Scleractinia Corals with Different Life-History Strategies: A Case Study about Pocillopora meandrina and Seriatopora hystrix in the South China Sea
Metabolomics Characterization of Scleractinia Corals with Different Life-History Strategies: A Case Study about Pocillopora meandrina and Seriatopora hystrix in the South China Sea Open
Life-history strategies play a critical role in susceptibility to environmental stresses for Scleractinia coral. Metabolomics, which is capable of determining the metabolic responses of biological systems to genetic and environmental chang…
View article: Metabolomics characterization of life-history strategies of scleractinian corals in the South China Sea: comparation of a dominant coral (Pocillopora meandrina) and a nondominant coral (Seriatopora hystrix)
Metabolomics characterization of life-history strategies of scleractinian corals in the South China Sea: comparation of a dominant coral (Pocillopora meandrina) and a nondominant coral (Seriatopora hystrix) Open
Life-history strategies play a critical role in susceptibility to environmental stresses for scleractinia coral. Metabolomics, which is regarded as the ultimate response of biological systems to genetic and environmental changes, is compet…
View article: Nematode-Trapping Fungi Produce Diverse Metabolites during Predator–Prey Interaction
Nematode-Trapping Fungi Produce Diverse Metabolites during Predator–Prey Interaction Open
Nematode-trapping fungi are natural antagonists of nematodes. These predatory fungi are capable of switching their lifestyle from a saprophytic to predatory stage in the presence of nematodes by developing specialized trapping devices to c…
View article: Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Typings of Edible Oils through Spectral Networking of Triacylglycerol Fingerprints
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Typings of Edible Oils through Spectral Networking of Triacylglycerol Fingerprints Open
Adulteration of edible oils by the manufacturers has been found frequently in modern societies. Due to the complexity of the chemical contents in edible oils, it is challenging to quantitatively determine the extent of adulteration and pro…
View article: Deep Lipidomics and Molecular Imaging of Unsaturated Lipid Isomers: A Universal Strategy Initiated by mCPBA Epoxidation
Deep Lipidomics and Molecular Imaging of Unsaturated Lipid Isomers: A Universal Strategy Initiated by mCPBA Epoxidation Open
Cellular lipidome is highly regulated through lipogenesis, rendering diverse double-bond positional isomers (C=C isomer) of a given unsaturated lipid species. In recent years, there are increasing reports indicating the physiological roles…