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View article: Revolutionizing thyroid nodule diagnosis in Hashimoto’s thyroiditis: AI-driven radiomics and deep learning model
Revolutionizing thyroid nodule diagnosis in Hashimoto’s thyroiditis: AI-driven radiomics and deep learning model Open
Objective: Accurately distinguishing between benign and malignant thyroid nodules(TNs) in the context of Hashimoto’s thyroiditis (HT) is challenging. This study aimed to explore the diagnostic efficacy of artificial intelligence (AI) model…
View article: The crosstalk between ubiquitination and GlcNAcylation of CHAF1A regulates HIV-1 latency and reactivation
The crosstalk between ubiquitination and GlcNAcylation of CHAF1A regulates HIV-1 latency and reactivation Open
The persistence of latent HIV-1 reservoirs remains a critical barrier to cure. Current “shock and kill” strategies are limited by ineffective latency-reversing agents (LRAs) and poor understanding of epigenetic regulation. Here, we identif…
View article: The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation
The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation Open
The persistence of latent HIV-1 reservoirs remains a critical barrier to functional curing AIDS, as current latency-reversing agents (LRAs) exhibit limited clinical efficacy. While RNA modifications like N⁶-methyladenosine (m⁶A) regulate v…
View article: Immediate versus delayed closure of facial dog-bite wounds: Retrospective analysis and nursing care experience
Immediate versus delayed closure of facial dog-bite wounds: Retrospective analysis and nursing care experience Open
Facial dog-bite injuries present a complex surgical challenge, balancing infection prevention with optimal cosmetic outcomes. While delayed primary closure (DPC) has traditionally been preferred to mitigate infection risk, immediate primar…
View article: Barriers and facilitators of implementing escape room in nursing education: a mixed-method systematic review protocol using an implementation framework.
Barriers and facilitators of implementing escape room in nursing education: a mixed-method systematic review protocol using an implementation framework. Open
CRD42024605953.
View article: Genetic Limitation and Conservation Implications in Tetracentron sinense: SNP-Based Analysis of Spatial Genetic Structure and Gene Flow
Genetic Limitation and Conservation Implications in Tetracentron sinense: SNP-Based Analysis of Spatial Genetic Structure and Gene Flow Open
The present research investigates the fine-scale spatial genetic structure (SGS) and gene flow dynamics in the endangered relict tree Tetracentron sinense, a keystone species in China’s montane ecosystems facing severe habitat fragmentatio…
View article: Leaf Trait Divergence and Elevational Adaptation in Endangered <i>Fagus hayatae</i>: Conservation Insights for an East Asian Paleoendemic
Leaf Trait Divergence and Elevational Adaptation in Endangered <i>Fagus hayatae</i>: Conservation Insights for an East Asian Paleoendemic Open
Fagus hayatae Palib. ex Hayata, an endangered East Asian paleoendemic species, dominates in Sichuan's Micang Mountain while persisting in fragmented populations across Taiwan and mainland China. Nevertheless, niche differentiation and adap…
View article: Traditional Chinese medicine for diabetic peripheral neuropathy: a network meta-analysis
Traditional Chinese medicine for diabetic peripheral neuropathy: a network meta-analysis Open
Background Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus, characterized by high morbidity and significant disability. Traditional Chinese medicine (TCM) has shown potential in relieving symptoms and imp…
View article: Work engagement and associated factors among Chinese nurses: a multi-centre cross-sectional study
Work engagement and associated factors among Chinese nurses: a multi-centre cross-sectional study Open
Not applicable.
View article: Targeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants
Targeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants Open
The emergence of SARS-CoV-2 variants has underscored the urgent need for innovative vaccine strategies that provide robust and enduring protection against diverse strains. Our study introduces the FP-HR5 nanoparticle vaccine, designed to t…
View article: HIV-1 Tat: Molecular Switch in Viral Persistence and Emerging Technologies for Functional Cure
HIV-1 Tat: Molecular Switch in Viral Persistence and Emerging Technologies for Functional Cure Open
HIV-1 Tat acts as a central molecular switch governing the transition between viral latency and active replication, making it a pivotal target for HIV-1 functional cure strategies. By binding to the viral long terminal repeat (LTR) and hij…
View article: Targeted Neuroimmune Modulation via FGF21‐Loaded Dual‐Layer Electrospun Nanofibrous Scaffold to Suppress Secondary Injury After Severe Traumatic Brain Injury
Targeted Neuroimmune Modulation via FGF21‐Loaded Dual‐Layer Electrospun Nanofibrous Scaffold to Suppress Secondary Injury After Severe Traumatic Brain Injury Open
Containment of secondary injury following severe traumatic brain injury (sTBI) is crucial for preserving neural tissue and function, especially when a dysregulated neuroimmune response exacerbates inflammation. However, effective therapeut…
View article: Improving Out-of-Distribution Detection via Dynamic Covariance Calibration
Improving Out-of-Distribution Detection via Dynamic Covariance Calibration Open
Out-of-Distribution (OOD) detection is essential for the trustworthiness of AI systems. Methods using prior information (i.e., subspace-based methods) have shown effective performance by extracting information geometry to detect OOD data w…
View article: EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1
EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1 Open
Invasive fungal infections (IFIs) have emerged as a significant health threat and cause approximately 3.75 million deaths per year globally. Understanding the detailed mechanism of the immune response to eliminate invasive fungal pathogens…
View article: Buccal Acupuncture Reduces the Dose of Sufentanil Needed in Laparoscopic Gynecological Surgery
Buccal Acupuncture Reduces the Dose of Sufentanil Needed in Laparoscopic Gynecological Surgery Open
BACKGROUND This study assessed the effects of buccal acupuncture on perioperative analgesia and serum inflammatory factors in patients undergoing laparoscopic gynecological surgery. MATERIAL AND METHODS Eighty patients who underwent electi…
View article: A new family of ant-associated fungi in <i>Chaetothyriales</i>.
A new family of ant-associated fungi in <i>Chaetothyriales</i>. Open
The order Chaetothyriales comprises the black yeasts and relatives, of which numerous species are prevalent as opportunists on human hosts. The present paper introduces a clade of species that live in ant nests inside hollow structures of …
View article: The association between emphysema detected on computed tomography and increased risk of lung cancer: a systematic review and meta-analysis
The association between emphysema detected on computed tomography and increased risk of lung cancer: a systematic review and meta-analysis Open
CT-defined emphysema was linked to an elevated risk of lung cancer, which was observed across various assessments. Moreover, the severity of COPD was found also to be a risk factor for the development of lung cancer.
View article: Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020
Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 Open
Background Oxidative stress plays a crucial role in the female reproductive system. The oxidative balance score (OBS) is a new measure for assessing the balance between antioxidant and pro-oxidative factors in diet and lifestyle. However, …
View article: Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation
Tannic acid reactivates HIV-1 latency by mediating CBX4 degradation Open
HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation of latent proviruses with latency-reversing agents (LRAs) is a p…
View article: Research on Airworthiness Certification and Risk Control of Minimum Unstick Speed for Civil Aircraft
Research on Airworthiness Certification and Risk Control of Minimum Unstick Speed for Civil Aircraft Open
VMU is the minimum speed at and above which the aircraft can safely lift off the ground and continue the takeoff, expressed in terms of calibrated airspeed, and is the basis for formulating other takeoff speeds of the aircraft. As a typica…