Tingjian Yan
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View article: Performance‐enhanced iterative learning control using a model‐free disturbance observer
Performance‐enhanced iterative learning control using a model‐free disturbance observer Open
This paper proposes a novel performance‐enhanced iterative learning control (ILC) scheme using a model‐free disturbance observer (DOB) to achieve high performance for precision motion systems that encounter non‐repetitive disturbances. As …
View article: Economic Burden of Neurologic Toxicities Associated with Treatment of Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma in the United States.
Economic Burden of Neurologic Toxicities Associated with Treatment of Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma in the United States. Open
BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy, which is approved for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL), can be associated with potentially severe and costly neurologic adverse events…
View article: <p>Impact of Atypical Antipsychotics as Adjunctive Therapy on Psychiatric Cost and Utilization in Patients with Major Depressive Disorder</p>
Impact of Atypical Antipsychotics as Adjunctive Therapy on Psychiatric Cost and Utilization in Patients with Major Depressive Disorder Open
Patients with major depressive disorder (MDD) incur high costs, despite established treatment options. Adding an atypical antipsychotic (AAP) to antidepressant therapy has shown to reduce depressive symptoms in MDD, but it remains unclear …
View article: Risk of hospitalization among patients with epilepsy using long versus short half-life adjunctive antiepileptic drugs
Risk of hospitalization among patients with epilepsy using long versus short half-life adjunctive antiepileptic drugs Open
In patients with uncontrolled epilepsy who were initiated on an adjunctive AED, the choice of an LHL versus SHL was associated with significantly lower risks of all-cause and epilepsy-related hospitalizations.
View article: <p>Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States</p>
Untangling the clinical and economic burden of hospitalization for cardiac amyloidosis in the United States Open
Hospitalization for cardiac amyloidosis is costly, with high rates of readmission and mortality. Opportunities exist to improve care.
View article: Medication Adherence, Health Care Utilization, and Costs in Patients With Major Depressive Disorder Initiating Adjunctive Atypical Antipsychotic Treatment
Medication Adherence, Health Care Utilization, and Costs in Patients With Major Depressive Disorder Initiating Adjunctive Atypical Antipsychotic Treatment Open
In patients with MDD and a variety of insurance types, brexpiprazole use was associated with statistically significantly lower risks of discontinuation, risk of hospital care (hospitalization and ED visits), and all-cause medical costs com…
View article: Atypical antipsychotic adherence is associated with lower inpatient utilization and cost in bipolar I disorder
Atypical antipsychotic adherence is associated with lower inpatient utilization and cost in bipolar I disorder Open
In the treatment of BD-I, better medication adherence to AAP was associated with fewer psychiatric hospitalizations. Among hospitalized patients, fully-adherent patients had statistically significantly lower psychiatric costs than partiall…
View article: Medication Adherence and Discontinuation of Aripiprazole Once-Monthly 400 mg (AOM 400) Versus Oral Antipsychotics in Patients with Schizophrenia or Bipolar I Disorder: A Real-World Study Using US Claims Data
Medication Adherence and Discontinuation of Aripiprazole Once-Monthly 400 mg (AOM 400) Versus Oral Antipsychotics in Patients with Schizophrenia or Bipolar I Disorder: A Real-World Study Using US Claims Data Open
Otsuka Pharmaceutical Development and Commercialization, Inc. and Lundbeck.
View article: Health Care Resource Use, Costs, and Diagnosis Patterns in Patients With Schizophrenia and Bipolar Disorder: Real-world Evidence From US Claims Databases
Health Care Resource Use, Costs, and Diagnosis Patterns in Patients With Schizophrenia and Bipolar Disorder: Real-world Evidence From US Claims Databases Open
Our analyses indicate that a substantial number of patients received diagnoses of both SCZ and BD-I, based on claims, in a 2.5-year period. Patients with a diagnosis of both SCZ and BD-I had higher health care utilization and costs than pa…
View article: Impact of initiating long-acting injectable antipsychotics on hospitalization in patients with bipolar I disorder
Impact of initiating long-acting injectable antipsychotics on hospitalization in patients with bipolar I disorder Open
Aim: To compare risk of hospitalization in patients with bipolar I disorder (BD-I) initiating long-acting injectable antipsychotics (LAIs). Materials & methods: Using Truven Health Analytics MarketScan ® (Medicaid, Commercial and Medicare …
View article: Epidemiology of AL amyloidosis: a real-world study using US claims data
Epidemiology of AL amyloidosis: a real-world study using US claims data Open
Key Points AL amyloidosis prevalence increased while incidence rates remained stable over a 9-year period (2007-2015).
View article: First-line systemic treatment adherence, healthcare resource utilization, and costs in patients with gastrointestinal neuroendocrine tumors (GI NETs) in the USA
First-line systemic treatment adherence, healthcare resource utilization, and costs in patients with gastrointestinal neuroendocrine tumors (GI NETs) in the USA Open
This study reports utilization and costs associated with different treatment therapies. Costs were higher in year 1 than year 2. This two-database study offers new information on the magnitude and trends in the cost of pharmacologically-tr…
View article: O8.5. SCHIZOPHRENIA AND BIPOLAR DISORDER DIAGNOSIS PATTERNS: REAL-WORLD EVIDENCE FROM US CLAIMS DATABASES
O8.5. SCHIZOPHRENIA AND BIPOLAR DISORDER DIAGNOSIS PATTERNS: REAL-WORLD EVIDENCE FROM US CLAIMS DATABASES Open
Schizophrenia and bipolar disorder (BD) are typically understood as separate and non-concurrent psychiatric disorders both in the clinical setting and in the DSM-V and ICD-10 classification systems. However, patients may experience both mo…
View article: F75. MEDICATION ADHERENCE AND DISCONTINUATION IN PATIENTS WITH SCHIZOPHRENIA TREATED WITH ARIPIPRAZOLE ONCE-MONTHLY LONG-ACTING INJECTABLE VERSUS THOSE TREATED WITH ORAL ANTIPSYCHOTICS
F75. MEDICATION ADHERENCE AND DISCONTINUATION IN PATIENTS WITH SCHIZOPHRENIA TREATED WITH ARIPIPRAZOLE ONCE-MONTHLY LONG-ACTING INJECTABLE VERSUS THOSE TREATED WITH ORAL ANTIPSYCHOTICS Open
Adherence to antipsychotic treatment is essential in treating schizophrenia symptoms and in preventing costly relapse. This study aimed to compare medication adherence and discontinuation in patients with schizophrenia treated with aripipr…
View article: S107. HEALTHCARE UTILIZATION AND COST IN SCHIZOPHRENIA AND BIPOLAR DISORDER: REAL-WORLD EVIDENCE FROM US CLAIMS DATABASES
S107. HEALTHCARE UTILIZATION AND COST IN SCHIZOPHRENIA AND BIPOLAR DISORDER: REAL-WORLD EVIDENCE FROM US CLAIMS DATABASES Open
BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BD) are distinct psychiatric disorders, but patients may be diagnosed with both. The objective of this study was to explore healthcare resource utilization (HCRU) and cost in patients w…
View article: Healthcare resource utilization and costs in amyloid light-chain amyloidosis: a real-world study using US claims data
Healthcare resource utilization and costs in amyloid light-chain amyloidosis: a real-world study using US claims data Open
Aim: To estimate healthcare utilization and costs in amyloid light-chain (AL) amyloidosis. Patients & methods: AL amyloidosis patients were identified in 2007–2015 claims databases if they had ≥1 inpatient/≥2 outpatient claims consistent w…
View article: Personalized Care and the Role of Insulin as a Vehicle to Optimizing Treatments in Diabetes Care
Personalized Care and the Role of Insulin as a Vehicle to Optimizing Treatments in Diabetes Care Open
This study was funded by Sanofi US. Bieszk and Wei are employees of Sanofi US. Grabner, Barron, and Quimbo are employees of HealthCore, which was under contract with Sanofi US for the conduct of this study. Yan is an employee of PHAR, LLC …
View article: Predictive factors associated with carcinoid syndrome in patients with gastrointestinal neuroendocrine tumors
Predictive factors associated with carcinoid syndrome in patients with gastrointestinal neuroendocrine tumors Open
GI NET patients with CS were 2-4 times as likely to have preexisting diagnoses (i.e., liver disorder, enlarged lymph nodes, abdominal mass) than non-CS patients.
View article: Costs associated with failure to respond to treatment among patients with rheumatoid arthritis initiating TNFi therapy: a retrospective claims analysis
Costs associated with failure to respond to treatment among patients with rheumatoid arthritis initiating TNFi therapy: a retrospective claims analysis Open
In this real-world study we found that, compared with matched nonresponders, patients who responded to TNFi treatments had lower all-cause medical, pharmacy, and total costs (excluding biologics) up to 3 years from initiation of TNFi thera…
View article: PP029 Hospitalizations And Costs In Bipolar Disorder Patients Initiating Long-acting Injectable Antipsychotics
PP029 Hospitalizations And Costs In Bipolar Disorder Patients Initiating Long-acting Injectable Antipsychotics Open
INTRODUCTION: Existing studies have not investigated the effectiveness of one long-acting injectable antipsychotic (LAI) versus another in preventing hospitalizations among patients with bipolar disorder (BD). This study was conducted to c…