Ting-Li Han
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View article: Two Cycles of Chemotherapy Modulate Itaconic Acid Levels via ATF3/TET2/NF-κB Pathways in Ovarian Cancer Among Han Chinese Women
Two Cycles of Chemotherapy Modulate Itaconic Acid Levels via ATF3/TET2/NF-κB Pathways in Ovarian Cancer Among Han Chinese Women Open
Background The optimal chemotherapy cycles after debulking surgery in ovarian cancer (OC) remain unclear. This prospective cohort was aimed to define metabolic changes induced by chemotherapy, determine the ideal regimen, and assess longit…
View article: Orthogonal assessment of six extraction methods for GC–MS based short-chain fatty acid quantification in fecal samples
Orthogonal assessment of six extraction methods for GC–MS based short-chain fatty acid quantification in fecal samples Open
Short-chain fatty acids (SCFAs) are prominent regulators of host physiology and are closely related to the pathophysiology of many metabolic diseases. SCFAs are predominately generated by microbial fermentation of dietary fiber in the gut.…
View article: Elucidating the role of fatty acid reprogramming in ovarian cancer: insights cross-talk between blood, subcutaneous fat, and ovarian cancer tissues
Elucidating the role of fatty acid reprogramming in ovarian cancer: insights cross-talk between blood, subcutaneous fat, and ovarian cancer tissues Open
Introduction Aberrant fatty acid (FA) metabolism is increasingly recognized as a significant factor in ovarian cancer (OC) progression, although the comprehensive metabolic alterations across different body tissues remain unclear. Methods …
View article: A metabolic fingerprint of ovarian cancer: a novel diagnostic strategy employing plasma EV-based metabolomics and machine learning algorithms
A metabolic fingerprint of ovarian cancer: a novel diagnostic strategy employing plasma EV-based metabolomics and machine learning algorithms Open
Ovarian cancer (OC) is the third most common malignant tumor of women and is accompanied by an alteration of systemic metabolism. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids has great potential for OC …
View article: Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro
Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro Open
Strain-specific evolution of resistance to linezolid among MRSA clinical isolates was firstly identified in this study. MRSA isolates with higher MICs for linezolid evolved more easily into resistant ones, which calls for precise monitorin…
View article: Relationship between prenatal metals exposure and neurodevelopment in one-year-old infants in the CLIMB study
Relationship between prenatal metals exposure and neurodevelopment in one-year-old infants in the CLIMB study Open
Prenatal exposure to selected metals or metal mixtures is associated with poorer neurodevelopment in one-year-old infants.
View article: Metabolic Profiles of Pregnancy With Polycystic Ovary Syndrome: Insights into Maternal-Fetal Metabolic Communication
Metabolic Profiles of Pregnancy With Polycystic Ovary Syndrome: Insights into Maternal-Fetal Metabolic Communication Open
Context Polycystic ovary syndrome (PCOS) pregnancies are linked to metabolic disorders affecting maternal and fetal outcomes, with maternal metabolites differing from those in normal pregnancies. Objective To investigate the metabolic comm…
View article: Chronic Nanoplastics Exposure Drives Lung Cancer Progression Through Atf3/Pck2 Axis-Mediated Rewiring of Truncated Gluconeogenesis
Chronic Nanoplastics Exposure Drives Lung Cancer Progression Through Atf3/Pck2 Axis-Mediated Rewiring of Truncated Gluconeogenesis Open
View article: Orthogonal Assessment of Six Extraction Methods for Gc-Ms Based Short-Chain Fatty Acids Quantification in Fecal Samples
Orthogonal Assessment of Six Extraction Methods for Gc-Ms Based Short-Chain Fatty Acids Quantification in Fecal Samples Open
View article: Plasma 5-Methoxytryptamine Depletion Links Tryptophan Metabolism to Menorrhagia in Adenomyosis: A Diagnostic and Therapeutic Target
Plasma 5-Methoxytryptamine Depletion Links Tryptophan Metabolism to Menorrhagia in Adenomyosis: A Diagnostic and Therapeutic Target Open
View article: Lipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion
Lipid imbalance and inflammatory oxylipin cascade at the maternal-fetal interface in recurrent spontaneous abortion Open
The study revealed alterations in omega-6 fatty acids, CD36 transport, and AA downstream oxylipins in RSA, which in turn promote M1 macrophage polarization. Thus, this research has established a foundation for identifying potential biomark…
View article: Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS
Metabolomic analysis of Agkistrodon haly venom poisoning mouse treatment by Jidesheng snake pill based on GC-MS Open
Introduction Snakebites are acute systemic toxic diseases caused by snake venom entering the body through wounds. Failure to use antivenom immediately and difficulty in obtaining antivenoms are frequently responsible for worsening disease.…
View article: The role of gut-brain tryptophan metabolism and fatty acid peroxidation in the effect of sleep deprivation on anxiety and depression in PCOS mice
The role of gut-brain tryptophan metabolism and fatty acid peroxidation in the effect of sleep deprivation on anxiety and depression in PCOS mice Open
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of childbearing age. Numerous studies have indicated a significantly elevated incidence of depression and anxiety in women affected by PCOS, often attribute…
View article: Associations of air pollution exposures in preconception and pregnancy with birth outcomes and infant neurocognitive development: analysis of the Complex Lipids in Mothers and Babies (CLIMB) prospective cohort in Chongqing, China
Associations of air pollution exposures in preconception and pregnancy with birth outcomes and infant neurocognitive development: analysis of the Complex Lipids in Mothers and Babies (CLIMB) prospective cohort in Chongqing, China Open
Objectives To investigate the associations of traffic-related air pollution exposures in early pregnancy with birth outcomes and infant neurocognitive development. Design Cohort study. Setting Eligible women attended six visits in the mate…
View article: Gut dysbiosis contributes to SCFAs reduction-associated adipose tissue macrophage polarization in gestational diabetes mellitus
Gut dysbiosis contributes to SCFAs reduction-associated adipose tissue macrophage polarization in gestational diabetes mellitus Open
Our study fills this knowledge gap by finding that alterations in gut microbiota have an independent impact on hyperglycemia and insulin resistance in the GDM state. In vivo and in vitro, gut dysbiosis is linked to adipose tissue inflammat…
View article: A Metabolic Fingerprint of Ovarian Cancer: A Novel Diagnostic Strategy Employing Plasma Exosome-Based Metabolomics and Machine Learning Algorithms
A Metabolic Fingerprint of Ovarian Cancer: A Novel Diagnostic Strategy Employing Plasma Exosome-Based Metabolomics and Machine Learning Algorithms Open
Ovarian cancer (OC) is the third most common malignant tumor of women and is accompanied by an alteration of systemic metabolism. A liquid biopsy that captures and detects tumor-related biomarkers in body fluids has great potential for OC …
View article: The metabolic role of the CD73/adenosine signaling pathway in HTR-8/SVneo cells: A Double-Edged Sword?
The metabolic role of the CD73/adenosine signaling pathway in HTR-8/SVneo cells: A Double-Edged Sword? Open
View article: The maternal hair metabolome is capable of discriminating intrahepatic cholestasis of pregnancy from uncomplicated pregnancy
The maternal hair metabolome is capable of discriminating intrahepatic cholestasis of pregnancy from uncomplicated pregnancy Open
Introduction Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with elevated bile acids in the blood. Diagnosis typically only occurs after the manifestation of clinical symptoms and the metabolic…
View article: Evidence for ethnicity and location as regulators of the newborn blood metabolome: a monozygous twin study
Evidence for ethnicity and location as regulators of the newborn blood metabolome: a monozygous twin study Open
Introduction Monochorionic, diamniotic (MCDA) monozygotic twins share nearly all genetic variation and a common placenta in utero . Despite this, MCDA twins are often discordant for a range of common phenotypes, including early growth and …
View article: Unraveling the Metabolic Mechanisms and Novel Biomarkers of Vulvar Lichen Simplex Chronicus Using Skin Biopsy and Tape Stripping Samples
Unraveling the Metabolic Mechanisms and Novel Biomarkers of Vulvar Lichen Simplex Chronicus Using Skin Biopsy and Tape Stripping Samples Open
View article: Metabolic Patterns of High-Invasive and Low-Invasive Oral Squamous Cell Carcinoma Cells Using Quantitative Metabolomics and 13C-Glucose Tracing
Metabolic Patterns of High-Invasive and Low-Invasive Oral Squamous Cell Carcinoma Cells Using Quantitative Metabolomics and 13C-Glucose Tracing Open
Most current metabolomics studies of oral squamous cell carcinoma (OSCC) are mainly focused on identifying potential biomarkers for early screening and diagnosis, while few studies have investigated the metabolic profiles promoting metasta…
View article: Alteration of Metabolic Profiles during the Progression of Alzheimer’s Disease
Alteration of Metabolic Profiles during the Progression of Alzheimer’s Disease Open
(1) Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that threatens the population health of older adults. However, the mechanisms of the altered metabolism involved in AD pathology are poorly understood. Th…
View article: Neonatal hair metabolome of birthweight discordant twins is associated with neurobehavioral impairments at 2-3 years of age
Neonatal hair metabolome of birthweight discordant twins is associated with neurobehavioral impairments at 2-3 years of age Open
Objective : To characterize the metabolic variation in neonatal hair samples associated with intrauterine growth discordance in dichorionic-diamniotic (DCDA) twins and to evaluate the effects of specific metabolic alterations on later neur…
View article: Probiotic Escherichia coli Nissle 1917-derived outer membrane vesicles modulate the intestinal microbiome and host gut-liver metabolome in obese and diabetic mice
Probiotic Escherichia coli Nissle 1917-derived outer membrane vesicles modulate the intestinal microbiome and host gut-liver metabolome in obese and diabetic mice Open
Introduction Obesity and diabetes are common chronic metabolic disorders which can cause an imbalance of the intestinal flora and gut-liver metabolism. Several studies have shown that probiotics, including Escherichia coli Nissle 1917 (EcN…
View article: Hair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment
Hair and cord blood element levels and their relationship with air pollution, dietary intake, gestational diabetes mellitus, and infant neurodevelopment Open
View article: Metabolomics analysis of serum metabolites during endometrial transformation: association with recurrent implantation failure in hormonal replacement therapy-frozen embryo transfers cycles
Metabolomics analysis of serum metabolites during endometrial transformation: association with recurrent implantation failure in hormonal replacement therapy-frozen embryo transfers cycles Open
View article: Chorionicity-associated variation in metabolic phenotype of cord blood in twin
Chorionicity-associated variation in metabolic phenotype of cord blood in twin Open
View article: The effect of growth hormone on the metabolome of follicular fluid in patients with diminished ovarian reserve
The effect of growth hormone on the metabolome of follicular fluid in patients with diminished ovarian reserve Open
View article: Alteration of Metabolic Profile During the Progression of Alzheimer’s Disease
Alteration of Metabolic Profile During the Progression of Alzheimer’s Disease Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that threatens the population health of older adults. However, the mechanisms of how altered metabolism involving in AD pathology are poorly understood. The aim of the st…
View article: Additional file 1 of Chorionicity-associated variation in metabolic phenotype of cord blood in twin
Additional file 1 of Chorionicity-associated variation in metabolic phenotype of cord blood in twin Open
Supplementary Material 1 Table 1: Identified metabolites