Explanipedia

Social determinants of health and life expectancy in US adults Open

Tingting Peng · 2025

Barrier-disrupting microneedle technology: Overcoming physical, physiological, and pathological skin defenses to enhance therapeutic efficacy Open

Zeshi Jiang, Wentao Wu, Wanshan Hu, Chunxian Zhou, Airu Lu , et al. · 2025

Microneedles (MNs) have gained increasing attention as an advanced transdermal delivery platform owing to their enhanced delivery performance compared to traditional systems. The key to enhancing MNs efficacy lies in overcoming multiple sk…

Switchable α‐Chalcogenocyanation and Chalcogenation of α‐Oxo Ketene Dithioacetals Open

Tingting Peng, Tianlin Xiao, Michael C. Gao, Ye Zhang, Xiao-Bo Zhao · 2025

The switchable α‐chalcogenocyanation and chalcogenation of α‐oxo ketene dithioacetals (DTAs) and NH 4 SCN/KSeCN have been developed by controlling reaction conditions. α‐Chalcogenocyanation reaction smoothly occurs in the presence of 2.0 e…

Photothermal and Combinatory Therapy as an Emerging Therapeutic Paradigm of Breast Cancer Treatment Open

Ikram Hasan, Lingyan Zhang, Tingting Peng, Zhenchang Wang · 2025

Breast cancer has a high mortality rate and is one of the most common malignancies among women. Conventional therapies such as radiotherapy, chemotherapy, and surgery are not sufficiently effective and have notable drawbacks, including tox…

Photothermal Combination Therapy for Metastatic Breast Cancer: A New Strategy and Future Perspectives Open

Zhenchang Wang, Ikram Hasan, Yinghe Zhang, Tingting Peng, Bing Guo · 2025

Metastatic breast cancer (MBC) remains one of the most aggressive and fatal malignancies in women, primarily due to tumor heterogeneity, multidrug resistance, and the limitations of conventional therapeutic approaches. Aim: This review aim…

Modeling Transient Waveforms of Offshore Wind Power AC/DC Transmission Faults: Unveiling Symmetry–Asymmetry Mechanisms Open

Yi Zheng, Qi Sheng You, Yujie Chen, Haoming Guo, Hao Yang , et al. · 2025

This paper aims to unveil the symmetry–asymmetry transition mechanisms in transient fault waveforms of offshore wind power AC/DC transmission systems, addressing the critical limitation of traditional simulation methods of the fact that th…

Fabrication, encapsulation, and hysteresis creep mitigation in Ionic Polymer-Metal Composites: A review Open

Lin Zhang, Tingting Peng, Yongshi Song, Yandong Li, Zhengyan Zhao · 2025

This systematic review examines the preparation and encapsulation processes for Ionic Polymer-Metal Composites (IPMCs) and evaluates methods for suppressing their characteristic hysteresis and creep. The analysis investigates the relations…

Editorial: Micro-nano-materials for drug delivery, disease diagnosis, and therapeutic treatment Open

Bing Guo, Tingting Peng, Chao Mi, Lei Ye · 2025

Revolutionizing psoriasis care: Microneedle innovations in treatment and diagnosis Open

Wanshan Hu, Hongwei Pan, Zhu Jiang, Jiawei Jian, Chunxian Zhou , et al. · 2025

Association between triglyceride glucose-waist height ratio index, hypothyroidism, and mortality in individuals with hypothyroidism: data from NHANES 2007-2012 Open

Tingting Peng, Xiaohua Gong, Weiyi Xu, Xuchen Deng, Zhongqiu Lu , et al. · 2025

Background: The aim of this study was to examine the associations between the triglyceride glucose-waist height ratio (TyG-WHtR) index and hypothyroidism, as well as mortality among individuals with hypothyroidism. Methods: Data collected …

Exploring the role of inflammation, immunity, and metabolism in colorectal cancer via mendelian randomization approach Open

Li Zhou, Mingjing Liao, Leilei Zhang, Tingting Peng, Chengyun Han , et al. · 2025

Colorectal cancer (CRC) is a prevalent type of cancer affecting the digestive system, characterized by a complex and not fully understood development process. Inflammation and metabolic processes are thought to play significant roles in bo…

X-ray-responsive dissolving microneedles mediate STING pathway activation to potentiate cutaneous melanoma radio-immunotherapy Open

Wen Hu, Xiaohong Hong, Xinyu Zhang, Hongfan Chen, X. Ma , et al. · 2025

Background: Radiotherapy (RT) often activates the cyclic GMP-AMP synthase (cGAS) stimulator of interferon response cGAMP interactor (STING) signaling pathway and induces systemic immunotherapy effects by triggering immunogenic cell …

Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy Open

Ting Wen, Yànpíng Fù, Xiangting Yi, Ying Sun, Wanchen Zhao , et al. · 2025

Integrating machine learning and genetic evidence to uncover novel gene biomarkers for colorectal cancer diagnosis Open

Li Zhou, Lihua Yu, Mingjing Liao, Tingting Peng, Leilei Zhang , et al. · 2025

Detection of an Orphan X-Ray Flare from a Blazar Candidate EP240709a with the Einstein Probe Open

Mingjun Liu, Yijia Zhang, Yun Wang, Rui Xue, D. A. H. Buckley , et al. · 2025

Blazars are often observed to flare across multiple wavelengths. Orphan flares from blazars have only been detected a few times, providing an opportunity to understand the structure of the jet in the accreting system. We report a remarkabl…

Comparison of robotic AI-assisted and manual pedicle screw fixation for treating thoracolumbar fractures: a retrospective controlled trial Open

Xun Xiao, XingKun Wang, Bin Meng, Tingting Peng, Hua Zhao · 2025

Objective To compare the clinical efficacy and screw placement accuracy of robot artificial intelligence (AI)-assisted percutaneous screw fixation and conventional C-arm-assisted percutaneous screw fixation (manual placement) in the treatm…

Active microneedle patch equipped with spontaneous bubble generation for enhanced rheumatoid arthritis treatment Open

Zhiyuan Liu, Jintao Fu, Ziyang Zheng, Minglong Chen, Wenhao Wang , et al. · 2025

Rationale: The utilization of dissolving microneedles (MNs) facilitates the painless delivery of pharmaceuticals via the transdermal route. However, conventional MNs rely on passive diffusion through the gradual dissolving of…

Microneedle-Mediated Treatment of Obesity Open

Hongwei Pan, Wanshan Hu, Changyang Zhou, Jiawei Jian, Jing Xu , et al. · 2025

Obesity has become a major public health threat, as it can cause various complications such as diabetes, cardiovascular disease, sleep apnea, cancer, and osteoarthritis. The primary anti-obesity therapies include dietary control, physical …

Epsilon-polylysine microneedle potentiating MXene-mediated photothermal ablation for combating antibiotic-resistant bacterial infections Open

Dongyi Xian, Rui Luo, Qiaoni Lin, Liqing Wang, Xiaoqian Feng , et al. · 2025

Antimicrobial peptides show promise in enhancing photothermal therapy, but their application is often limited by the challenge of constructing a delivery system that balances efficacy and safety. Our research demonstrated that the bacteric…

High mRNA Expression of 24 Dehydrocholesterol Reductase (DHCR24) in the Treatment of Doxorubicin-Induced Heart Failure in Rats Open

Rui Zhang, Siyuan Peng, Xuejuan Zhang, Zhengwei Huang, Tingting Peng · 2025

Objective: The objective of this study was to explore the possibility of treating heart failure in rats by delivering mRNA of 24-dehydrocholesterol reductase (DHCR24) into the body through lipid nanoparticles (LNPs). Methods: We establishe…

Detection of an Orphan X-ray Flare from a Blazar Candidate EP240709a with Einstein Probe Open

Mingjun Liu, Yijia Zhang, Yun Wang, Rui Xue, David N. Buckley , et al. · 2024

Blazars are often observed to flare across multiple wavelengths. Orphan flares from blazars have been only detected a few times, providing an opportunity to understand the structure of the jet in the accreting system. We report a remarkabl…

METTL16 suppresses ferroptosis in cholangiocarcinoma by promoting ATF4 via m<sup>6</sup>A modification Open

Senfeng Zhao, Jiahui Cao, Ruopeng Liang, Tingting Peng, Shitao Wu , et al. · 2024

Background: N6-methyladenosine (m⁶A) modification is the most common post-transcriptional modifications, which is critical for the metabolism of ferroptosis-related RNAs. Yet, the impact of m⁶A modification on …

Employing Microsoft Sway as a Repository for Data Generated in Pharmaceutics Experimental Courses: A Case study on Topical Formulation Characterization Open

Qingxin Chen, Rui Luo, Chuanbin Wu, Tingting Peng, Zuyi Huang · 2024

Microsoft Sway is an easy-to-use online creative software developed by Microsoft. It has many advantages as follows: easy to operate and does not require long-term practice and learning; network links can be created and accessed by devices…

Microneedle technology for enhanced topical treatment of skin infections Open

Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu , et al. · 2024

Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for sk…

Triggering the Untriggered: The First Einstein Probe-detected Gamma-Ray Burst 240219A and Its Implications Open

Yi-Han Iris Yin, Bin‐Bin Zhang, Jun Yang, Hui Sun, Chen Zhang , et al. · 2024

The Einstein Probe (EP) achieved its first detection and localization of a bright X-ray flare, EP240219a, on 2024 February 19, during its commissioning phase. Subsequent targeted searches triggered by the EP240219a alert identified a faint…

Silencing LncRNA3643 inhibit the apoptosis and inflammation of LPS induced HK-2 cell Open

Siqi Li, Qin Yan, Guifu Qin, Lu Wei, Xietian Yin , et al. · 2024

Purpose The aim of this study was to investigate the effects of si-lncRNA3643 on the proliferation, apoptosis, and inflammatory response of HK2 cells and its possible mechanism. Methods HK2 cells were divided into four groups: control, lip…

Hydrogel local drug delivery systems for postsurgical management of tumors: Status Quo and perspectives Open

Ziqiao Zhong, Lu Gan, Ziyi Feng, Wenhao Wang, Tingting Peng , et al. · 2024

Mammo-Clustering: A Multi-views Tri-level Information Fusion Context Clustering Framework for Localization and Classification in Mammography Open

Shilong Yang, Chulong Zhang, Qi Zang, Juan Yu, Liang Zeng , et al. · 2024

Breast cancer is a significant global health issue, and the diagnosis of breast imaging has always been challenging. Mammography images typically have extremely high resolution, with lesions occupying only a very small area. Down-sampling …

Emerging Trends in Dissolving-Microneedle Technology for Antimicrobial Skin-Infection Therapies Open

Rui Luo, Huihui Xu, Qiaoni Lin, Jiaying Chi, Tingzhi Liu , et al. · 2024

Skin and soft-tissue infections require significant consideration because of their prolonged treatment duration and propensity to rapidly progress, resulting in severe complications. The primary challenge in their treatment stems from the …

Chemodynamic Therapy of Glioblastoma Multiforme and Perspectives Open

Zia Ullah, Y. Abbas, Jingsi Gu, Sai Ko Soe, Shubham Roy , et al. · 2024

Glioblastoma multiforme (GBM), a potential public health issue, is a huge challenge for the advanced scientific realm to solve. Chemodynamic therapy (CDT) based on the Fenton reaction emerged as a state-of-the-art therapeutic modality to t…

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