Ting‐Wei Lin
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View article: Discrepant Treponemal Test Results: Identification of Associated Risk Factors Through Machine Learning Technology in 18-Year Electronic Medical Records and National Claims Data
Discrepant Treponemal Test Results: Identification of Associated Risk Factors Through Machine Learning Technology in 18-Year Electronic Medical Records and National Claims Data Open
Risk factor identification and machine learning model development can support the interpretation of serological tests for syphilis, enabling accurate diagnosis and clinical decision-making.
View article: Mutational Analysis of Colistin-Resistant Pseudomonas aeruginosa Isolates: From Genomic Background to Antibiotic Resistance
Mutational Analysis of Colistin-Resistant Pseudomonas aeruginosa Isolates: From Genomic Background to Antibiotic Resistance Open
This study analyzed eleven isolates of colistin-resistant Pseudomonas aeruginosa, originating from Portugal and Taiwan, which are associated with various pathologies. The results revealed significant genetic diversity among the isolates, w…
View article: Identifying heterogeneous subgroups of systemic autoimmune diseases by applying a joint dimension reduction and clustering approach to immunomarkers
Identifying heterogeneous subgroups of systemic autoimmune diseases by applying a joint dimension reduction and clustering approach to immunomarkers Open
The immunomarker-driven clustering method could recognise more clinically relevant subgroups of the SADs and would provide a more precise diagnosis basis.
View article: A pilot pharmacokinetic and Metabolite identification study of Erinacine A in a Single landrace pig model
A pilot pharmacokinetic and Metabolite identification study of Erinacine A in a Single landrace pig model Open
View article: Identifying heterogeneous subgroups of systemic autoimmune diseases by applying a joint dimension reduction and clustering approach to immunomarkers
Identifying heterogeneous subgroups of systemic autoimmune diseases by applying a joint dimension reduction and clustering approach to immunomarkers Open
Background The high complexity of systemic autoimmune diseases (SADs) has hindered precise management. This study aims to investigate heterogeneity in SADs. Methods We applied a joint cluster analysis, which jointed multiple correspondence…
View article: Discovery of a New Compound, Erinacerin W, from the Mycelia of Hericium erinaceus, with Immunomodulatory and Neuroprotective Effects
Discovery of a New Compound, Erinacerin W, from the Mycelia of Hericium erinaceus, with Immunomodulatory and Neuroprotective Effects Open
One new compound with an isoindolinone skeleton, along with erinacines A, C, and S, was isolated from the mycelia of Hericium erinaceus, an edible fungus with a long history of use in traditional Chinese medicine. Based on analysis of MS a…
View article: Discrepancy Results of Treponemal Tests: Exploring the Associated Risk Factors Using Machine Learning Technology Based on 18 Years of Electronic Medical Records and National Claims Data
Discrepancy Results of Treponemal Tests: Exploring the Associated Risk Factors Using Machine Learning Technology Based on 18 Years of Electronic Medical Records and National Claims Data Open
Background Syphilis is becoming more prevalent and is diagnosed primarily through serologic tests. Confirmatory treponemal tests (TTs), such as Treponema pallidum particle agglutination (TPPA) and fluorescent treponema antibody absorption …
View article: The algorithm and implementation of an extension to LLVM for solving the blocking between instruction sink and division-modulo combine
The algorithm and implementation of an extension to LLVM for solving the blocking between instruction sink and division-modulo combine Open
Compiler optimization presents a formidable challenge, seeking to enhance code quality through various techniques. One significant obstacle is the phase-ordering problem, where the sequence of optimization algorithms can impact code qualit…
View article: Trend of HPV Molecular Epidemiology in the Post-Vaccine Era: A 10-Year Study
Trend of HPV Molecular Epidemiology in the Post-Vaccine Era: A 10-Year Study Open
Cervical cancer, a major health concern among women worldwide, is closely linked to human papillomavirus (HPV) infection. This study explores the evolving landscape of HPV molecular epidemiology in Taiwan over a decade (2010–2020), where p…
View article: Aortic root remodeling after surgical repair of acute type A aortic dissection using different anastomosis techniques
Aortic root remodeling after surgical repair of acute type A aortic dissection using different anastomosis techniques Open
The telescopic anastomosis technique is a safe alternative to the continuous anastomosis technique in the surgical repair of aTAAD, with comparable early results. In addition, telescopic anastomosis was associated with beneficial aortic ro…
View article: Antrodin C Isolated from Antrodia Cinnamomea Induced Apoptosis through ROS/AKT/ERK/P38 Signaling Pathway and Epigenetic Histone Acetylation of TNFα in Colorectal Cancer Cells
Antrodin C Isolated from Antrodia Cinnamomea Induced Apoptosis through ROS/AKT/ERK/P38 Signaling Pathway and Epigenetic Histone Acetylation of TNFα in Colorectal Cancer Cells Open
Background: Antrodin C, a maleimide derivative compound isolated from the ethanol extract of the mycelium of Antrodia cinnamomea, is an endemic fungus of Taiwan and a potential chemoprotective agent. However, the molecular mechanisms under…
View article: Rapid and Accurate Discrimination of Mycobacterium abscessus Subspecies Based on Matrix-Assisted Laser Desorption Ionization-Time of Flight Spectrum and Machine Learning Algorithms
Rapid and Accurate Discrimination of Mycobacterium abscessus Subspecies Based on Matrix-Assisted Laser Desorption Ionization-Time of Flight Spectrum and Machine Learning Algorithms Open
Mycobacterium abscessus complex (MABC) has been reported to cause complicated infections. Subspecies identification of MABC is crucial for adequate treatment due to different antimicrobial resistance properties amid subspecies. However, lo…
View article: Tag-Free SARS-CoV-2 Receptor Binding Domain (RBD), but Not C-Terminal Tagged SARS-CoV-2 RBD, Induces a Rapid and Potent Neutralizing Antibody Response
Tag-Free SARS-CoV-2 Receptor Binding Domain (RBD), but Not C-Terminal Tagged SARS-CoV-2 RBD, Induces a Rapid and Potent Neutralizing Antibody Response Open
Recombinant proteins are essential in the development of subunit vaccines. In the design of many recombinant proteins, polyhistidine residues are added to the N- or C-termini of target sequences to facilitate purification. However, whether…
View article: Relationship between obesity-related parameters and chronic kidney disease in middle-aged and elderly populations in Taiwan: A community-based study
Relationship between obesity-related parameters and chronic kidney disease in middle-aged and elderly populations in Taiwan: A community-based study Open
Globally, obesity is a major health problem and can markedly increase the risk of various diseases, including type 2 diabetes mellitus, hypertension (HTN), dyslipidemia, and chronic kidney disease (CKD). The association of obesity-related …
View article: Effect of an Artificial Intelligence-assisted Antibiotic Susceptibility Test on Reducing the Mortality Rate of and Antibiotics Use in Patients with Bacteremia: A Prospective Observational Cohort Study
Effect of an Artificial Intelligence-assisted Antibiotic Susceptibility Test on Reducing the Mortality Rate of and Antibiotics Use in Patients with Bacteremia: A Prospective Observational Cohort Study Open
No mass spectrometry-based antibiotic susceptibility test (AST) AI system has been robustly validated and truly deployed in real-world settings. In the study, an AI-assisted AST prediction system XBugHunter was extensively validated and de…
View article: α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes
α-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes Open
Cell–matrix adhesions are mainly provided by integrin-mediated focal adhesions (FAs). We previously found that Shp2 is essential for FA maturation by promoting ROCK2 activation at FAs. In this study, we further delineated the role of α-act…
View article: Rapid and accurate discrimination of <i>Mycobacterium abscessus</i> subspecies based on matrix-assisted laser desorption ionization-time of flight spectrum and machine learning algorithms
Rapid and accurate discrimination of <i>Mycobacterium abscessus</i> subspecies based on matrix-assisted laser desorption ionization-time of flight spectrum and machine learning algorithms Open
Background Mycobacterium abscessus complex (MABC) has been reported to cause considerable complicated infections. Subspecies identification of MABC is crucial for adequate treatment due to different antimicrobial resistance property amid t…
View article: Effect of an Artificial Intelligence-assisted Antibiotic Susceptibility Test on Reducing the Mortality Rate of and Antibiotics Use in Patients with Bacteremia: A Prospective Observational Cohort Study
Effect of an Artificial Intelligence-assisted Antibiotic Susceptibility Test on Reducing the Mortality Rate of and Antibiotics Use in Patients with Bacteremia: A Prospective Observational Cohort Study Open
Importance Although various computational approaches have been proposed for pathogen detection, no artificial intelligence (AI)-assisted antibiotic susceptibility test (AST) system has been robustly validated and truly deployed in a clinic…
View article: A New In Situ Coaxial Capacitive Sensor Network for Debris Monitoring of Lubricating Oil
A New In Situ Coaxial Capacitive Sensor Network for Debris Monitoring of Lubricating Oil Open
Wear debris monitoring of lubricant oil is an important method to determine the health and failure mode of key components such as bearings and gears in rotatory machines. The permittivity of lubricant oil can be changed when the wear debri…
View article: Investigating Unfavorable Factors That Impede MALDI-TOF-Based AI in Predicting Antibiotic Resistance
Investigating Unfavorable Factors That Impede MALDI-TOF-Based AI in Predicting Antibiotic Resistance Open
The combination of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) spectra data and artificial intelligence (AI) has been introduced for rapid prediction on antibiotic susceptibility testing (AST) of Staphylococcus a…
View article: Identification of Common Liver Metabolites of the Natural Bioactive Compound Erinacine A, Purified from Hericium erinaceus Mycelium
Identification of Common Liver Metabolites of the Natural Bioactive Compound Erinacine A, Purified from Hericium erinaceus Mycelium Open
Metabolite identification, in the early stage, for compound discovery is necessary to assess the knowledge for the pharmaceutical improvement of drug safety and efficacy. Even if the drug has been released into the market, identification a…
View article: Erratum for Wang et al., “Clinically Applicable System for Rapidly Predicting Enterococcus faecium Susceptibility to Vancomycin”
Erratum for Wang et al., “Clinically Applicable System for Rapidly Predicting Enterococcus faecium Susceptibility to Vancomycin” Open
View article: Investigating the Unfavored Factors That Interfere MALDI-TOF Based AI in Predicting Antibiotic Resistance
Investigating the Unfavored Factors That Interfere MALDI-TOF Based AI in Predicting Antibiotic Resistance Open
Combining Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) spectra data and artificial intelligence (AI) has been introduced for rapid prediction on antibiotic susceptibility test (AST) of S. aureus. Based on the AI p…
View article: Energy Efficiency of Inference Algorithms for Clinical Laboratory Data Sets: Green Artificial Intelligence Study
Energy Efficiency of Inference Algorithms for Clinical Laboratory Data Sets: Green Artificial Intelligence Study Open
Background The use of artificial intelligence (AI) in the medical domain has attracted considerable research interest. Inference applications in the medical domain require energy-efficient AI models. In contrast to other types of data in v…
View article: Extensive validation and prospective observation of the impact of an AI-based rapid antibiotics susceptibility prediction platform in multiple medical centers
Extensive validation and prospective observation of the impact of an AI-based rapid antibiotics susceptibility prediction platform in multiple medical centers Open
Importance No medical artificial intelligence (AI) has been robustly validated and deployed in a clinical laboratory in real-world settings, and the clinical impact of the medical AI remains unknown. Objective To deploy a medical AI platfo…
View article: Towards a more efficient approach for the satisfiability of two-variable logic
Towards a more efficient approach for the satisfiability of two-variable logic Open
We revisit the satisfiability problem for two-variable logic, denoted by SAT(FO2), which is known to be NEXP-complete. The upper bound is usually derived from its well known Exponential Size Model (ESM) property. Whether it can be determin…
View article: Outcomes of acute type A aortic dissection operations performed by early-career cardiovascular surgeons
Outcomes of acute type A aortic dissection operations performed by early-career cardiovascular surgeons Open
View article: Energy Efficiency of Inference Algorithms for Clinical Laboratory Data Sets: Green Artificial Intelligence Study (Preprint)
Energy Efficiency of Inference Algorithms for Clinical Laboratory Data Sets: Green Artificial Intelligence Study (Preprint) Open
BACKGROUND The use of artificial intelligence (AI) in the medical domain has attracted considerable research interest. Inference applications in the medical domain require energy-efficient AI models. In contrast to other types of data in …
View article: Development of a two-step nucleic acid amplification test for accurate diagnosis of the Mycobacterium tuberculosis complex
Development of a two-step nucleic acid amplification test for accurate diagnosis of the Mycobacterium tuberculosis complex Open
The Mycobacterium tuberculosis complex (MTBC) remains one of the top 10 leading causes of death globally. The early diagnosis of MTBC can reduce mortality and mitigate disease transmission. However, current nucleic acid amplification diagn…
View article: Molecular Epidemiology of Cytomegalovirus UL97 and UL54 variants in Taiwan
Molecular Epidemiology of Cytomegalovirus UL97 and UL54 variants in Taiwan Open
The results demonstrate that the positive rate of CMV DNAemia was 15.3% (112/729) among the patients with clinical CMV infection symptoms. The proportion of antiviral resistance CMV strains within CMV DNAemia patients was 3.6%. With the in…