Tinnakorn Chaiworapongsa
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View article: The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study
The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study Open
Background: Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Most cases of preterm birth occur spontaneously and result from preterm labor with intact (spontaneous preterm labor [sPTL]) or ruptured (preterm…
View article: Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing
Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing Open
Labor is a complex physiological process requiring a well-orchestrated dialogue between the mother and fetus. However, the cellular contributions and communications that facilitate maternal-fetal cross-talk in labor have not been fully elu…
View article: A mitochondrial regulator protein, MNRR1, is elevated in the maternal blood of women with preeclampsia
A mitochondrial regulator protein, MNRR1, is elevated in the maternal blood of women with preeclampsia Open
MNRR1, a mitochondrial regulator protein, is elevated in the maternal plasma of women with preeclampsia (both early and late) at the time of diagnosis. These findings may reflect some degree of mitochondrial dysfunction, intravascular infl…
View article: Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein
Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein Open
CHCHD2/MNRR1 is physiologically present in the plasma of healthy non-pregnant and normal pregnant women, and its concentration does not change with gestational age and parturition at term. However, plasma CHCHD2/MNRR1 is elevated in women …
View article: Meconium-stained amniotic fluid
Meconium-stained amniotic fluid Open
View article: A biomarker for bacteremia in pregnant women with acute pyelonephritis: soluble suppressor of tumorigenicity 2 or sST2
A biomarker for bacteremia in pregnant women with acute pyelonephritis: soluble suppressor of tumorigenicity 2 or sST2 Open
Objective: Sepsis is a leading cause of maternal death, and its diagnosis during the golden hour is critical to improve survival. Acute pyelonephritis in pregnancy is a risk factor for obstetrical and medical complications, a…
View article: Evidence for the participation of CHCHD2/MNRR1, a mitochondrial protein, in spontaneous labor at term and in preterm labor with intra-amniotic infection
Evidence for the participation of CHCHD2/MNRR1, a mitochondrial protein, in spontaneous labor at term and in preterm labor with intra-amniotic infection Open
CHCHD2/MNRR1 is a physiological constituent of human amniotic fluid in normal pregnancy, and the amniotic concentration of this mitochondrial protein increases during pregnancy, labor at term, and preterm labor with intra-amniotic infectio…
View article: The vaginal microbiota of pregnant women varies with gestational age, maternal age, and parity
The vaginal microbiota of pregnant women varies with gestational age, maternal age, and parity Open
The composition of the vaginal microbiota is heavily influenced by pregnancy and may factor into pregnancy complications, including spontaneous preterm birth. However, results among studies have been inconsistent, due in part to variation …
View article: The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma
The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma Open
The intra-uterine components of labor, namely, myometrial contractility, cervical ripening, and decidua/membrane activation, have been extensively characterized and involve a local pro-inflammatory milieu of cellular and soluble immune med…
View article: Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death
Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death Open
Pregnant women with fetal death have different concentrations of 19 proteins in the EV and soluble fractions compared to controls, and the direction of changes in concentration was similar between fractions. The combination of EV and solub…
View article: Acute pyelonephritis in pregnancy and plasma syndecan-1: evidence of glycocalyx involvement
Acute pyelonephritis in pregnancy and plasma syndecan-1: evidence of glycocalyx involvement Open
Plasma syndecan-1 concentration is higher in pregnant women and increases as a function of gestational age. Patients with acute pyelonephritis have a higher plasma concentration of syndecan-1, and this is particularly the case in the prese…
View article: Maternal plasma syndecan-1: a biomarker for fetal growth restriction
Maternal plasma syndecan-1: a biomarker for fetal growth restriction Open
Low maternal plasma syndecan-1 may reflect placental diseases and this protein could be a biomarker for fetal growth restriction. However, as a sole biomarker for this condition, its accuracy is low.
View article: Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death
Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death Open
Fetal death is a complication of pregnancy caused by multiple etiologies rather than being the end-result of a single disease process. Many soluble analytes in the maternal circulation, such as hormones and cytokines, have been implicated …
View article: The profiles of soluble adhesion molecules in the “great obstetrical syndromes”*
The profiles of soluble adhesion molecules in the “great obstetrical syndromes”* Open
Objective: The objective of this study was to determine the profiles of maternal plasma soluble adhesion molecules in patients with preeclampsia, small-for-gestational-age (SGA) fetuses, acute pyelonephritis, preterm labor with inta…
View article: Evidence for the participation of CHCHD2/MNRR1, a mitochondrial protein, in spontaneous labor at term and in preterm labor with intra-amniotic infection
Evidence for the participation of CHCHD2/MNRR1, a mitochondrial protein, in spontaneous labor at term and in preterm labor with intra-amniotic infection Open
Intra-amniotic inflammation (IAI), associated with either microbe (infection) or danger signals (sterile), plays a major role in the pathophysiology of preterm labor and delivery. Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CH…
View article: Soluble suppression of tumorigenicity-2 in pregnancy with a small-for-gestational-age fetus and with preeclampsia
Soluble suppression of tumorigenicity-2 in pregnancy with a small-for-gestational-age fetus and with preeclampsia Open
Preeclampsia and disorders of fetal growth are conditions characterized by intravascular inflammation, as reflected by maternal plasma concentrations of sST2. The severity of intravascular inflammation is highest in patients with preeclamp…
View article: The Vaginal Microbiota in Early Pregnancy Identifies a Subset of Women at Risk for Early Preterm Prelabor Rupture of Membranes and Preterm Birth
The Vaginal Microbiota in Early Pregnancy Identifies a Subset of Women at Risk for Early Preterm Prelabor Rupture of Membranes and Preterm Birth Open
Spontaneous preterm birth (sPTB) can occur when vaginal bacteria gain access to the amniotic cavity. Thus, the predictive value of the vaginal microbiota for sPTB has been investigated, yet results have been inconclusive. Here, we report t…
View article: Perturbations in kinetics of the thrombin generation assay identify women at risk of preeclampsia in the first trimester and provide the rationale for a preventive approach
Perturbations in kinetics of the thrombin generation assay identify women at risk of preeclampsia in the first trimester and provide the rationale for a preventive approach Open
View article: Preeclampsia at term can be classified into 2 clusters with different clinical characteristics and outcomes based on angiogenic biomarkers in maternal blood
Preeclampsia at term can be classified into 2 clusters with different clinical characteristics and outcomes based on angiogenic biomarkers in maternal blood Open
View article: Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology
Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology Open
View article: Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma
Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma Open
Pregnant women are at greater risk of adverse outcomes, including mortality, as well as obstetrical complications resulting from COVID-19. However, pregnancy-specific changes that underlie such worsened outcomes remain unclear. Herein, we …
View article: The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix
The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix Open
View article: Characterization of amniotic fluid sludge in preterm and term gestations
Characterization of amniotic fluid sludge in preterm and term gestations Open
The nature of amniotic fluid particulate material varies as a function of gestational age. The material obtained in preterm gestations is frequently related to an inflammatory process, while that obtained at term is often consistent with v…
View article: The role of the placenta in spontaneous preterm labor and delivery with intact membranes
The role of the placenta in spontaneous preterm labor and delivery with intact membranes Open
Objectives To determine whether placental vascular pathology and impaired placental exchange due to maturational defects are involved in the etiology of spontaneous preterm labor and delivery in cases without histologic acute chorioamnioni…
View article: The amniotic fluid proteome changes with gestational age in normal pregnancy: a cross-sectional study
The amniotic fluid proteome changes with gestational age in normal pregnancy: a cross-sectional study Open
The cell-free transcriptome in amniotic fluid (AF) has been shown to be informative of physiologic and pathologic processes in pregnancy; however, the change in AF proteome with gestational age has mostly been studied by targeted approache…
View article: A novel biomarker for bacteremia in acute pyelonephritis during pregnancy
A novel biomarker for bacteremia in acute pyelonephritis during pregnancy Open
View article: An abnormal thrombin generation profile in early pregnancy identifies patients at risk for preeclampsia
An abnormal thrombin generation profile in early pregnancy identifies patients at risk for preeclampsia Open
View article: Preeclampsia and pyelonephritis: two different types of endothelial cell dysfunction?
Preeclampsia and pyelonephritis: two different types of endothelial cell dysfunction? Open
View article: Fetal growth restriction is characterized by changes in a biomarker of glycocalyx integrity
Fetal growth restriction is characterized by changes in a biomarker of glycocalyx integrity Open
View article: Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth
Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth Open
Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn deaths, remains challenging given the syndromic nature of the disease. We report a longitudinal multi-omics study coupled with a DREAM challenge to …